Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0071 | 0.032 | 0.0331 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.9663 | 1 |
Onchocerca volvulus | 0.0071 | 0.032 | 0.0331 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0071 | 0.032 | 0.032 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0193 | 0.4029 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0071 | 0.032 | 0.0331 |
Brugia malayi | Trypsin family protein | 0.0071 | 0.032 | 0.0331 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0071 | 0.032 | 0.032 |
Brugia malayi | Trypsin family protein | 0.0378 | 0.9663 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0071 | 0.032 | 0.032 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.3478 | 0.36 |
Toxoplasma gondii | cytochrome b | 0.0193 | 0.4029 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.9663 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.032 | 0.0331 |
Brugia malayi | Trypsin family protein | 0.0071 | 0.032 | 0.0331 |
Onchocerca volvulus | 0.0307 | 0.7492 | 0.7753 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0071 | 0.032 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.032 | 0.0331 |
Mycobacterium ulcerans | hypothetical protein | 0.0071 | 0.032 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0193 | 0.4029 | 0.4029 |
Onchocerca volvulus | 0.0071 | 0.032 | 0.0331 | |
Echinococcus granulosus | cytochrome B | 0.0193 | 0.4029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.032 | 0.0331 |
Plasmodium vivax | cytochrome b | 0.0193 | 0.4029 | 0.5 |
Brugia malayi | hypothetical protein | 0.0071 | 0.032 | 0.0331 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0071 | 0.032 | 0.032 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.032 | 0.032 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0071 | 0.032 | 0.032 |
Onchocerca volvulus | 0.0071 | 0.032 | 0.0331 | |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.3478 | 1 |
Loa Loa (eye worm) | cytochrome b | 0.0193 | 0.4029 | 0.417 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.032 | 0.0331 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.3478 | 0.3478 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0071 | 0.032 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.032 | 0.0331 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0071 | 0.032 | 0.032 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0071 | 0.032 | 0.032 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0071 | 0.032 | 0.032 |
Onchocerca volvulus | 0.0071 | 0.032 | 0.0331 | |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.032 | 0.032 |
Plasmodium falciparum | cytochrome b | 0.0193 | 0.4029 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.3329 | 0.8112 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0378 | 0.9663 | 0.9663 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0071 | 0.032 | 0.032 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0071 | 0.032 | 0.032 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.3478 | 0.36 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0071 | 0.032 | 0.0331 |
Toxoplasma gondii | apocytochrome b, putative | 0.0193 | 0.4029 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0193 | 0.4029 | 0.4029 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0071 | 0.032 | 0.032 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0071 | 0.032 | 0.0331 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0071 | 0.032 | 0.032 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0071 | 0.032 | 0.032 |
Onchocerca volvulus | 0.0071 | 0.032 | 0.0331 | |
Onchocerca volvulus | 0.0378 | 0.9663 | 1 | |
Brugia malayi | cytochrome b | 0.0193 | 0.4029 | 0.417 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0071 | 0.032 | 0.032 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0071 | 0.032 | 0.032 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.