Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | transient receptor potential cation channel, subfamily C, member 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | short transient receptor potential channel 6 | transient receptor potential cation channel, subfamily C, member 4 | 890 aa | 799 aa | 31.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cytochrome b | 0.0319 | 0.1377 | 0.5429 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0113 | 0.0223 | 0.0804 |
Toxoplasma gondii | apocytochrome b, putative | 0.0522 | 0.2518 | 1 |
Toxoplasma gondii | cytochrome b | 0.0522 | 0.2518 | 1 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0117 | 0.0245 | 1 |
Mycobacterium ulcerans | ubiquinol-cytochrome C reductase QcrB | 0.1855 | 1 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0117 | 0.0245 | 0.0892 |
Mycobacterium tuberculosis | Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) | 0.1855 | 1 | 0.5 |
Echinococcus granulosus | cytochrome B | 0.0522 | 0.2518 | 1 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0113 | 0.0223 | 0.9015 |
Brugia malayi | cytochrome b | 0.0319 | 0.1377 | 0.5 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0117 | 0.0245 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0245 | 0.1777 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0522 | 0.2518 | 0.5 |
Loa Loa (eye worm) | cytochrome b | 0.0319 | 0.1377 | 1 |
Onchocerca volvulus | 0.1855 | 1 | 0.5 | |
Schistosoma mansoni | cytochrome b | 0.0522 | 0.2518 | 1 |
Plasmodium vivax | cytochrome b | 0.0522 | 0.2518 | 0.5 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0117 | 0.0245 | 0.0892 |
Plasmodium falciparum | cytochrome b | 0.0522 | 0.2518 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 1.188 uM | PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that activate transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2237, AID2259] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.