Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0114 | 0.1743 | 0.4365 |
Mycobacterium ulcerans | hypothetical protein | 0.01 | 0.1448 | 0.3552 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.009 | 0.1236 | 0.3407 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0213 | 0.379 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.01 | 0.1448 | 0.3552 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0038 | 0.0158 | 0.0416 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0213 | 0.379 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.019 | 0.3323 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.019 | 0.3323 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0075 | 0.0927 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.019 | 0.3323 | 1 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0114 | 0.1743 | 0.4365 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0038 | 0.0158 | 0.5 |
Mycobacterium ulcerans | 3-dehydroquinate synthase | 0.0213 | 0.379 | 1 |
Chlamydia trachomatis | dehyroquinate synthase | 0.0213 | 0.379 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.009 | 0.1236 | 0.3643 |
Mycobacterium leprae | 3-dehydroquinate synthase AroB | 0.0213 | 0.379 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0075 | 0.0927 | 0.5 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0213 | 0.379 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0075 | 0.0927 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.019 | 0.3323 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.