Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0159 | 0.0887 | 0.5648 |
Toxoplasma gondii | cytochrome b | 0.0427 | 0.2686 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0159 | 0.0887 | 0.3302 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0159 | 0.0887 | 0.3302 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0191 | 0.1215 |
Schistosoma mansoni | cytochrome b | 0.0427 | 0.2686 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0427 | 0.2686 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0887 | 0.5648 |
Onchocerca volvulus | 0.1515 | 1 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0159 | 0.0887 | 0.5648 |
Loa Loa (eye worm) | cytochrome b | 0.0261 | 0.157 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0788 | 0.502 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0191 | 0.2151 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0191 | 0.071 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0191 | 0.1215 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0788 | 0.502 |
Echinococcus multilocularis | acetylcholinesterase | 0.0159 | 0.0887 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0887 | 0.5648 |
Echinococcus granulosus | acetylcholinesterase | 0.0159 | 0.0887 | 0.3302 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0159 | 0.0887 | 0.5648 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0191 | 0.071 |
Echinococcus multilocularis | acetylcholinesterase | 0.0159 | 0.0887 | 1 |
Brugia malayi | cytochrome b | 0.0261 | 0.157 | 1 |
Plasmodium falciparum | cytochrome b | 0.0427 | 0.2686 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0159 | 0.0887 | 0.3302 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0191 | 0.071 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0191 | 0.2151 |
Echinococcus granulosus | cytochrome B | 0.0427 | 0.2686 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0788 | 0.502 |
Toxoplasma gondii | apocytochrome b, putative | 0.0427 | 0.2686 | 1 |
Schistosoma mansoni | cytochrome b | 0.0261 | 0.157 | 0.5846 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0159 | 0.0887 | 1 |
Mycobacterium tuberculosis | Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) | 0.1515 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0191 | 0.071 |
Plasmodium vivax | cytochrome b | 0.0427 | 0.2686 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0191 | 0.071 |
Brugia malayi | Carboxylesterase family protein | 0.0159 | 0.0887 | 0.5648 |
Mycobacterium ulcerans | ubiquinol-cytochrome C reductase QcrB | 0.1515 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.