Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0049 | 0.004 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0109 | 0.2112 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0192 | 0.5014 | 0.4994 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0109 | 0.2112 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0192 | 0.5014 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0287 | 0.8305 | 1 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0144 | 0.3331 | 0.3331 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0049 | 0.004 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0109 | 0.2112 | 0.208 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0336 | 1 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.212 | 0.212 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0109 | 0.2112 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase (beta subunit) | 0.0049 | 0.004 | 0.004 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0336 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0169 | 0.4208 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0192 | 0.5014 | 0.4994 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0336 | 1 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0109 | 0.212 | 0.1778 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.2541 | 0.2541 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.212 | 0.212 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0336 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0336 | 1 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0049 | 0.004 | 0.5 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0336 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0192 | 0.5014 | 0.4994 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.006 | 0.0417 | 0.0378 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0049 | 0.004 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.2541 | 0.2541 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.2541 | 0.2217 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0049 | 0.004 | 0.5 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0049 | 0.004 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0287 | 0.8305 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0049 | 0.004 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.4208 | 0.1249 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.212 | 0.212 |
Loa Loa (eye worm) | ILVBL protein | 0.0203 | 0.5402 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0336 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.4208 | 0.1249 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0192 | 0.5026 | 0.9303 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0109 | 0.2112 | 1 |
Treponema pallidum | pyruvate oxidoreductase | 0.0049 | 0.004 | 0.5 |
Leishmania major | phosphonopyruvate decarboxylase-like protein | 0.0109 | 0.2112 | 0.4212 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0049 | 0.004 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.212 | 0.212 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.212 | 0.212 |
Echinococcus multilocularis | geminin | 0.0169 | 0.4208 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.212 | 0.212 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0192 | 0.5014 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.2541 | 0.2541 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0192 | 0.5014 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.