TDR Targets

Basic information

Technical information

TDR Targets ID: 1491442
Name: 5-(3-methylphenyl)-2H-tetrazole
MW: 160.176 | Formula: C8H8N4
H donors: 1 H acceptors: 3 LogP: 1.57 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)c1nnn[nH]1
InChi: 1S/C8H8N4/c1-6-3-2-4-7(5-6)8-9-11-12-10-8/h2-5H,1H3,(H,9,10,11,12)
InChiKey: GWZNHKMUSLKULV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(3-methylphenyl)-2H-1,2,3,4-tetrazole
ST5408415
5-(m-Tolyl)(1H)tetrazole
5-(m-Tolyl)-1H-tetrazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	hypothetical protein	0.0217	0.3008	0.293
Schistosoma mansoni	hypothetical protein	0.0038	0.0261	0.0307
Mycobacterium tuberculosis	Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS)	0.0671	1	1
Giardia lamblia	Pyruvate-flavodoxin oxidoreductase	0.0098	0.1172	0.5
Echinococcus granulosus	geminin	0.0177	0.2403	0.9351
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0098	0.1172	1
Mycobacterium leprae	Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS)	0.0671	1	1
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0244	0.0134
Brugia malayi	beta-lactamase family protein	0.0037	0.0244	0.0244
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0408	1
Mycobacterium ulcerans	lipase LipD	0.0037	0.0244	0.0134
Mycobacterium tuberculosis	Probable oxalyl-CoA decarboxylase OxcA	0.0671	1	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0244	0.0411
Mycobacterium ulcerans	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	0.0119	0.1505	0.141
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0244	0.0411
Mycobacterium ulcerans	hypothetical protein	0.0671	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0408	0.0594
Brugia malayi	bHLH-PAS transcription factor	0.0029	0.0111	0.0111
Mycobacterium tuberculosis	Probable reductase	0.0109	0.1354	0.1138
Brugia malayi	hypothetical protein	0.0188	0.257	0.257
Onchocerca volvulus		0.0037	0.0244	0.2078
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0238	0.3339	0.3173
Schistosoma mansoni	aryl hydrocarbon receptor	0.0039	0.0266	0.0313
Leishmania major	trypanothione reductase	0.0048	0.0408	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0244	0.0411
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0038	0.0261	0.0261
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0408	0.0688
Entamoeba histolytica	pyruvate:ferredoxin oxidoreductase	0.0098	0.1172	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0087	0.0147
Plasmodium falciparum	acyl-CoA synthetase	0.0384	0.5581	1
Schistosoma mansoni	hypothetical protein	0.0027	0.0087	0.0103
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0109	0.1354	0.1138
Loa Loa (eye worm)	hypoxia-induced factor 1	0.012	0.1516	0.256
Onchocerca volvulus	Huntingtin homolog	0.0098	0.1172	1
Onchocerca volvulus		0.0029	0.0111	0.0946
Brugia malayi	glutathione reductase	0.0048	0.0408	0.0408
Mycobacterium ulcerans	2-oxoglutarate ferredoxin oxidoreductase subunit beta	0.0098	0.1172	0.1073
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0244	0.0244
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0098	0.1172	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0027	0.0087	0.0087
Brugia malayi	hypothetical protein	0.0098	0.1172	0.1172
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0098	0.1172	1
Loa Loa (eye worm)	thiamine pyrophosphate enzyme	0.0384	0.5591	0.9437
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0408	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0244	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0188	0.257	0.4339
Onchocerca volvulus		0.0038	0.0261	0.2226
Brugia malayi	Thioredoxin reductase	0.0048	0.0408	0.0408
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0109	0.1354	0.1138
Onchocerca volvulus		0.0037	0.0244	0.2078
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0244	0.0134
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0122	0.1542	0.1331
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0408	0.0168
Loa Loa (eye worm)	hypothetical protein	0.013	0.1672	0.2821
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0098	0.1172	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0244	0.0253
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0109	0.1354	0.1138
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0122	0.1542	0.1331
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.004	0.0281	0.0281
Trypanosoma cruzi	phosphonopyruvate decarboxylase, putative	0.0217	0.3008	1
Leishmania major	putative pyruvate/indole-pyruvate carboxylase, putative	0.0384	0.5581	1
Mycobacterium ulcerans	acetolactate synthase	0.0384	0.5581	0.5531
Mycobacterium ulcerans	acetolactate synthase 1 catalytic subunit	0.0671	1	1
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0098	0.1172	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0408	0.1586
Trypanosoma brucei	trypanothione reductase	0.0048	0.0408	0.0594
Mycobacterium tuberculosis	Probable dehydrogenase	0.0109	0.1354	0.1138
Brugia malayi	beta-lactamase family protein	0.0037	0.0244	0.0244
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0408	0.0424
Brugia malayi	hypoxia-induced factor 1	0.012	0.1516	0.1516
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0244	0.0948
Trypanosoma brucei	phosphonopyruvate decarboxylase-like protein, putative	0.0217	0.3008	1
Trypanosoma cruzi	phosphonopyruvate decarboxylase, putative	0.0217	0.3008	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1172	0.1979
Trichomonas vaginalis	pyruvate-flavodoxin oxidoreductase, putative	0.0098	0.1172	1
Brugia malayi	hypothetical protein	0.013	0.1672	0.1672
Mycobacterium leprae	PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SH	0.0119	0.1505	0.1293
Mycobacterium leprae	PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE)	0.0671	1	1
Echinococcus granulosus	survival motor neuron protein 1	0.0188	0.257	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0244	0.0134
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0244	0.0287
Schistosoma mansoni	hypothetical protein	0.0177	0.2403	0.2829
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.004	0.0281	0.0474
Loa Loa (eye worm)	ILVBL protein	0.0406	0.5925	1
Echinococcus granulosus	single minded 2	0.0029	0.0111	0.0431
Brugia malayi	beta-lactamase	0.0037	0.0244	0.0244
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0646	0.9618	1
Trypanosoma brucei	phosphonopyruvate decarboxylase-like protein, putative	0.0217	0.3008	1
Onchocerca volvulus	Huntingtin homolog	0.0098	0.1172	1
Echinococcus multilocularis	geminin	0.0177	0.2403	0.2499
Mycobacterium tuberculosis	Probable oxidoreductase	0.0122	0.1542	0.1331
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0244	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0244	0.0411
Mycobacterium ulcerans	acetolactate synthase large subunit IlvB	0.0384	0.5581	0.5531
Treponema pallidum	pyruvate oxidoreductase	0.0098	0.1172	0.5
Echinococcus multilocularis	survival motor neuron protein 1	0.0188	0.257	0.2672
Mycobacterium tuberculosis	Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase)	0.0287	0.4088	0.3941
Loa Loa (eye worm)	hypothetical protein	0.004	0.0281	0.0474
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0408	0.0688
Mycobacterium tuberculosis	Probable oxidoreductase (beta subunit)	0.0098	0.1172	0.0951
Brugia malayi	Calcitonin receptor-like protein seb-1	0.004	0.0281	0.0281
Schistosoma mansoni	single-minded	0.0039	0.0266	0.0313
Leishmania major	phosphonopyruvate decarboxylase-like protein	0.0217	0.3008	0.518
Plasmodium vivax	acyl-CoA synthetase, putative	0.0384	0.5581	1
Schistosoma mansoni	hypothetical protein	0.0177	0.2403	0.2829
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0109	0.1354	0.1138
Mycobacterium ulcerans	pyruvate or indole-3-pyruvate decarboxylase Pdc	0.0384	0.5581	0.5531
Schistosoma mansoni	acetolactate synthase	0.0573	0.8497	1
Schistosoma mansoni	acetolactate synthase	0.0573	0.8497	1
Brugia malayi	PAS domain containing protein	0.0039	0.0266	0.0266
Mycobacterium ulcerans	putative oxalyl-CoA decarboxylase	0.0671	1	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0244	0.0134
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0408	0.0308
Schistosoma mansoni	survival motor neuron protein	0.0038	0.0261	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1172	0.1979
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0244	0.0287
Echinococcus multilocularis	transfer RNA-Lys	0.0029	0.0111	0.0115
Onchocerca volvulus		0.0037	0.0244	0.2078
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0122	0.1542	0.1331
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0244	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0244	0.0411
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0109	0.1354	0.1138

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1650272

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1491442