Detailed information for compound 1491616

Basic information

Technical information
  • TDR Targets ID: 1491616
  • Name: N-(2-furan-2-yl-2-morpholin-4-ylethyl)-N'-[(4 -methylphenyl)methyl]oxamide
  • MW: 371.43 | Formula: C20H25N3O4
  • H donors: 2 H acceptors: 2 LogP: 1.4 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CNC(=O)C(=O)NCC(c1ccco1)N1CCOCC1
  • InChi: 1S/C20H25N3O4/c1-15-4-6-16(7-5-15)13-21-19(24)20(25)22-14-17(18-3-2-10-27-18)23-8-11-26-12-9-23/h2-7,10,17H,8-9,11-14H2,1H3,(H,21,24)(H,22,25)
  • InChiKey: MJNWXSVOISNWKO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-(2-furyl)-2-morpholino-ethyl]-N'-[(4-methylphenyl)methyl]oxamide
  • N-[2-(2-furyl)-2-morpholinoethyl]-N'-[(4-methylphenyl)methyl]oxamide
  • N-[2-(2-furyl)-2-morpholino-ethyl]-N'-(4-methylbenzyl)oxamide
  • N-(2-furan-2-yl-2-morpholin-4-yl-ethyl)-N'-[(4-methylphenyl)methyl]ethanediamide
  • MLS000696835
  • SMR000237232

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0509 0.0241
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0134 0.3422 0.3422
Mycobacterium ulcerans hydrolase 0.0134 0.3422 0.5
Trichomonas vaginalis beta lactamase domain, putative 0.0134 0.3422 1
Leishmania major metallo-beta-lactamase family protein-like protein 0.0134 0.3422 1
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0134 0.3422 1
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0134 0.3422 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.3422 1
Entamoeba histolytica type A flavoprotein, putative 0.0134 0.3422 1
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0134 0.3422 1
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0134 0.3422 1
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0134 0.3422 1
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0134 0.3422 0.3422
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0134 0.3422 1
Schistosoma mansoni hypothetical protein 0.0134 0.3422 0.3422
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0437 0.0437
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0134 0.3422 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0134 0.3422 1
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0134 0.3422 0.3422
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0134 0.3422 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0691 0.0851
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3712 0.3712
Brugia malayi metallo-beta-lactamase superfamily protein 0.0134 0.3422 0.9218
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.3422 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0134 0.3422 0.5
Trichomonas vaginalis beta lactamase domain, putative 0.0134 0.3422 1
Brugia malayi ethe1-prov protein 0.0134 0.3422 0.9218
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0134 0.3422 0.5
Mycobacterium leprae Beta-lactamase-like protein 0.0134 0.3422 0.5
Plasmodium vivax unspecified product 0.0134 0.3422 1
Onchocerca volvulus Putative hydrolase PNKD 0.0134 0.3422 0.5
Mycobacterium tuberculosis Conserved protein 0.0134 0.3422 0.5
Trypanosoma cruzi glyoxalase II 0.0134 0.3422 1
Entamoeba histolytica metallo-beta-lactamase family protein 0.0134 0.3422 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0691 0.0851
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0134 0.3422 1
Mycobacterium leprae POSSIBLE HYDROLASE 0.0134 0.3422 0.5
Trichomonas vaginalis beta lactamase domain, putative 0.0134 0.3422 1
Mycobacterium ulcerans hypothetical protein 0.0134 0.3422 0.5
Mycobacterium ulcerans hydrolase 0.0134 0.3422 0.5
Trypanosoma cruzi glyoxalase II 0.0134 0.3422 1
Schistosoma mansoni zinc phosphodiesterase 0.0134 0.3422 0.3422
Echinococcus multilocularis zinc phosphodiesterase 0.0134 0.3422 0.3422
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0437 0.0437
Plasmodium falciparum cytosolic glyoxalase II 0.0134 0.3422 1
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0134 0.3422 1
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0134 0.3422 1
Entamoeba histolytica hypothetical protein, conserved 0.0134 0.3422 1
Schistosoma mansoni hypothetical protein 0.0372 1 1
Chlamydia trachomatis ribonuclease Z 0.0134 0.3422 0.5
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0134 0.3422 0.3422
Onchocerca volvulus 0.0134 0.3422 0.5
Brugia malayi hypothetical protein 0.0134 0.3422 0.9218
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0134 0.3422 0.3422
Echinococcus granulosus importin subunit beta 1 0.0035 0.0691 0.0691
Loa Loa (eye worm) hypothetical protein 0.0134 0.3422 0.3422
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.3422 1
Trichomonas vaginalis beta lactamase domain, putative 0.0134 0.3422 1
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0134 0.3422 1
Schistosoma mansoni ran 0.0026 0.0437 0.0437
Mycobacterium tuberculosis Conserved hypothetical protein 0.0134 0.3422 0.5
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0509 0.0241
Leishmania major hypothetical protein, conserved 0.0134 0.3422 1
Onchocerca volvulus 0.0134 0.3422 0.5
Mycobacterium tuberculosis Beta lactamase like protein 0.0134 0.3422 0.5
Trichomonas vaginalis beta lactamase domain, putative 0.0134 0.3422 1
Entamoeba histolytica metallo-beta-lactamase family protein 0.0134 0.3422 1
Mycobacterium ulcerans hypothetical protein 0.0134 0.3422 0.5
Schistosoma mansoni ran 0.0026 0.0437 0.0437
Brugia malayi RNA, U transporter 1 0.0099 0.2465 0.6639
Mycobacterium ulcerans hydrolase 0.0134 0.3422 0.5
Plasmodium falciparum importin beta, putative 0.0035 0.0691 0.0851
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0691 0.0851
Mycobacterium ulcerans glyoxalase II, GloB 0.0134 0.3422 0.5
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0509 0.0241
Echinococcus granulosus zinc phosphodiesterase 0.0134 0.3422 0.3422
Mycobacterium tuberculosis Conserved protein 0.0134 0.3422 0.5
Schistosoma mansoni hypothetical protein 0.0134 0.3422 0.3422
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3712 0.3712
Brugia malayi Importin beta-1 subunit 0.0035 0.0691 0.1861
Mycobacterium ulcerans hypothetical protein 0.0134 0.3422 0.5
Echinococcus multilocularis ETHE1 protein 0.0134 0.3422 0.3422
Brugia malayi MH2 domain containing protein 0.0144 0.3712 1
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0134 0.3422 0.9218
Echinococcus multilocularis snurportin 1 0.0372 1 1
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0134 0.3422 0.3422
Mycobacterium tuberculosis Possible hydrolase 0.0134 0.3422 0.5
Entamoeba histolytica type A flavoprotein, putative 0.0134 0.3422 1
Entamoeba histolytica alkyl sulfatase, putative 0.0134 0.3422 1
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0134 0.3422 1
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0134 0.3422 0.3422
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0134 0.3422 0.3422
Schistosoma mansoni hypothetical protein 0.0134 0.3422 0.3422
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0134 0.3422 1
Mycobacterium tuberculosis Possible hydrolase 0.0134 0.3422 0.5
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0134 0.3422 1
Trichomonas vaginalis beta lactamase domain, putative 0.0134 0.3422 1
Entamoeba histolytica alkyl sulfatase, putative 0.0134 0.3422 1
Leishmania major metallo-beta-lactamase family-like protein 0.0134 0.3422 1
Mycobacterium ulcerans beta lactamase-like protein 0.0134 0.3422 0.5
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0134 0.3422 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.3422 0.3422
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0509 0.0241
Loa Loa (eye worm) hypothetical protein 0.0134 0.3422 0.3422
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0437 0.1176
Schistosoma mansoni importin beta-1 0.0035 0.0691 0.0691
Echinococcus granulosus ETHE1 protein 0.0134 0.3422 0.3422
Loa Loa (eye worm) hypothetical protein 0.0134 0.3422 0.3422
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.3422 1
Schistosoma mansoni zinc phosphodiesterase 0.0134 0.3422 0.3422
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.3422 1
Mycobacterium ulcerans hypothetical protein 0.0134 0.3422 0.5
Entamoeba histolytica metallo-beta-lactamase family protein 0.0134 0.3422 1
Trichomonas vaginalis A-type flavoprotein 0.0134 0.3422 1
Brugia malayi metallo-beta-lactamase superfamily protein 0.0134 0.3422 0.9218
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0691 0.0691
Treponema pallidum ribonuclease Z 0.0134 0.3422 0.5
Mycobacterium leprae conserved hypothetical protein 0.0134 0.3422 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0134 0.3422 0.5
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0134 0.3422 0.3422
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0134 0.3422 0.3422
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0437 0.0437
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0134 0.3422 1
Trypanosoma brucei glyoxalase II 0.0134 0.3422 1
Mycobacterium leprae conserved hypothetical protein 0.0134 0.3422 0.5
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0134 0.3422 1
Trypanosoma cruzi glyoxalase II 0.0134 0.3422 1
Mycobacterium tuberculosis Conserved protein 0.0134 0.3422 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0691 0.0691
Trichomonas vaginalis apoptosis inducing factor, putative 0.0134 0.3422 1
Entamoeba histolytica hypothetical protein 0.0028 0.0509 0.0241
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0134 0.3422 0.5
Leishmania major importin beta-1 subunit, putative 0.0028 0.0509 0.0241
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0134 0.3422 1
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.3422 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0691 0.0851
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0134 0.3422 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.2643 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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