Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0571 | 1 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0111 | 0.1191 | 0.1191 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0185 | 0.2603 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0111 | 0.1191 | 0.1191 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0571 | 1 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0083 | 0.066 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0571 | 1 | 1 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0083 | 0.066 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.2366 | 0.052 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0571 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0123 | 0.1427 | 0.1427 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0123 | 0.1427 | 0.046 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0571 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase (beta subunit) | 0.0083 | 0.066 | 0.066 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0185 | 0.2603 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0327 | 0.5325 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0185 | 0.2603 | 0.208 |
Schistosoma mansoni | acetolactate synthase | 0.0488 | 0.841 | 1 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0083 | 0.066 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0111 | 0.1191 | 0.1191 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0327 | 0.5325 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0111 | 0.1191 | 0.1191 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0327 | 0.5336 | 0.938 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.2366 | 0.052 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0185 | 0.2603 | 1 |
Leishmania major | phosphonopyruvate decarboxylase-like protein | 0.0185 | 0.2603 | 0.4889 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0327 | 0.5325 | 0.4994 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0327 | 0.5325 | 0.4994 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0123 | 0.1427 | 0.1427 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0083 | 0.066 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0123 | 0.1427 | 0.1427 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0111 | 0.1191 | 0.1191 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0083 | 0.066 | 0.5 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0111 | 0.1191 | 0.0197 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0083 | 0.066 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0488 | 0.841 | 1 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0244 | 0.3746 | 0.3746 |
Mycobacterium tuberculosis | Probable reductase | 0.0111 | 0.1191 | 0.1191 |
Loa Loa (eye worm) | ILVBL protein | 0.0346 | 0.5689 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0571 | 1 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0185 | 0.2603 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0327 | 0.5325 | 0.4994 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0327 | 0.5325 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0571 | 1 | 1 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0102 | 0.1013 | 0.0378 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0083 | 0.066 | 0.5 |
Echinococcus multilocularis | geminin | 0.0172 | 0.2366 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0083 | 0.066 | 0.5 |
Echinococcus granulosus | geminin | 0.0172 | 0.2366 | 1 |
Treponema pallidum | pyruvate oxidoreductase | 0.0083 | 0.066 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | Inhibition of de novo lipogenesis in C57B1/6 mouse assessed as 14C-acetic acid incorporation at 30 mg/kg, ip administration 1 hr before substrate addition and measured after 1 hr by scintillation counter | ChEMBL. | 24900234 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.