Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glycine transporter 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0019 | 0.0022 | 0.0022 |
Plasmodium falciparum | transporter, putative | 0.0019 | 0.0022 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0 | 0.0003 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0022 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0242 | 0.0926 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0576 | 0.2208 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.0576 | 0.2208 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0 | 0.0003 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0096 | 0.0576 | 0.0576 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0022 | 0.0085 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.013 | 0.0497 |
Brugia malayi | NADH dehydrogenase subunit 1 | 0.0378 | 0.261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0576 | 0.2208 |
Mycobacterium tuberculosis | Possible formate hydrogenlyase HycD (FHL) | 0.0378 | 0.261 | 0.261 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0019 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0085 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0 | 0.0001 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0 | 0.0003 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.1403 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0085 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0019 | 0.0022 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0019 | 0.0022 | 0.0022 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0.0022 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.1403 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0019 | 0.0022 | 0.0383 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.013 | 0.0497 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0242 | 0.0926 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | NADH dehydrogenase subunit 1 | 0.0378 | 0.261 | 0.261 |
Brugia malayi | hypothetical protein | 0.0378 | 0.261 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.0576 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0022 | 0.0085 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0019 | 0.0022 | 0.0085 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0019 | 0.0022 | 0.0022 |
Onchocerca volvulus | 0.0378 | 0.261 | 1 | |
Plasmodium vivax | amine transporter, putative | 0.0019 | 0.0022 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0022 | 0.0085 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0019 | 0.0022 | 0.0022 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0022 | 0.0085 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.0735 | 0.2814 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0019 | 0.0022 | 0.0022 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0085 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0019 | 0.0022 | 0.0022 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0242 | 0.0926 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0085 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0019 | 0.0022 | 0.0022 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0019 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0085 |
Plasmodium vivax | hypothetical protein, conserved | 0.0019 | 0.0022 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0 | 0.0001 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0019 | 0.0022 | 0.0085 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.0735 | 0.2814 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.0576 | 0.0576 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0019 | 0.0022 | 0.0022 |
Plasmodium falciparum | amino acid transporter, putative | 0.0019 | 0.0022 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0019 | 0.0022 | 0.0085 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.0576 | 0.2208 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0019 | 0.0022 | 0.0022 |
Brugia malayi | NADH dehydrogenase subunit 1, identical | 0.0378 | 0.261 | 1 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0019 | 0.0022 | 0.0383 |
Echinococcus granulosus | serotonin transporter | 0.0019 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0242 | 0.0926 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.0576 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0.0022 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1403 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0096 | 0.0576 | 0.0576 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0019 | 0.0022 | 0.0085 |
Loa Loa (eye worm) | NADH dehydrogenase subunit 1 | 0.0378 | 0.261 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0019 | 0.0022 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0019 | 0.0022 | 0.0022 |
Onchocerca volvulus | 0.0378 | 0.261 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0085 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0019 | 0.0022 | 0.0022 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.013 | 0.013 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase subunit H | 0.1403 | 1 | 0.5 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0019 | 0.0022 | 0.0383 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0019 | 0.0022 | 0.0022 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.0576 | 0.0576 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0019 | 0.0022 | 0.0022 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0.0022 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0 | 0.0003 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0022 | 0.0085 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.0735 | 0.2814 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0019 | 0.0022 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0085 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.