Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.0017 | 0.0096 |
Brugia malayi | Fucosyl transferase family protein | 0.0051 | 0.1789 | 1 |
Brugia malayi | alpha1,3-fucosyltransferase homologue | 0.0051 | 0.1789 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0032 | 0.1093 | 0.4693 |
Echinococcus granulosus | glycoprotein 3 alpha L fucosyltransferase | 0.0012 | 0.0339 | 0.1456 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0169 | 0.6074 | 0.5913 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0066 | 0.233 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0012 | 0.0339 | 0.0883 |
Echinococcus multilocularis | roundabout 2 | 0.0004 | 0.0077 | 0.0329 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0032 | 0.1093 | 0.0727 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0012 | 0.0339 | 0.0883 |
Echinococcus granulosus | neuroglian | 0.0004 | 0.0043 | 0.0186 |
Chlamydia trachomatis | dehyroquinate synthase | 0.0108 | 0.3841 | 0.3587 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0051 | 0.1789 | 0.4657 |
Echinococcus multilocularis | Immunoglobulin | 0.0003 | 0.0017 | 0.0074 |
Brugia malayi | thymidylate synthase | 0.0032 | 0.1093 | 0.6113 |
Brugia malayi | Dihydrofolate reductase | 0.0013 | 0.0395 | 0.2211 |
Onchocerca volvulus | 0.0032 | 0.1093 | 0.737 | |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0043 | 0.1484 | 1 |
Echinococcus multilocularis | neuroglian | 0.0004 | 0.0043 | 0.0186 |
Schistosoma mansoni | alpha 13/4 fucosyltransferase Lewis 1 | 0.004 | 0.1364 | 0.3552 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0046 | 0.1574 | 1 |
Echinococcus granulosus | glycoprotein 3 alpha L fucosyltransferase | 0.0012 | 0.0339 | 0.1456 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0004 | 0.0051 | 0.0217 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.0017 | 0.0096 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0476 | 0.2659 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0013 | 0.0395 | 0.2211 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0012 | 0.0339 | 0.0883 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0003 | 0.0017 | 0.0096 |
Schistosoma mansoni | tyrosine kinase | 0.0066 | 0.233 | 0.6066 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0012 | 0.0339 | 0.0883 |
Echinococcus granulosus | alpha13fucosyltransferase | 0.0012 | 0.0339 | 0.1456 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0012 | 0.0339 | 0.0883 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0013 | 0.0395 | 0.1697 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0032 | 0.1093 | 0.2026 |
Echinococcus granulosus | dihydrofolate reductase | 0.0013 | 0.0395 | 0.1697 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0066 | 0.233 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0339 | 0.1897 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0012 | 0.0339 | 0.1456 |
Echinococcus granulosus | defective proboscis extension response | 0.0003 | 0.0017 | 0.0074 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0012 | 0.0339 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0077 | 0.0429 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0051 | 0.1789 | 0.4657 |
Echinococcus multilocularis | Immunoglobulin | 0.0003 | 0.0017 | 0.0074 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0012 | 0.0339 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.0017 | 0.0096 |
Loa Loa (eye worm) | thymidylate synthase | 0.0032 | 0.1093 | 0.6113 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0169 | 0.6074 | 0.5913 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.0017 | 0.0096 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0046 | 0.1574 | 1 |
Echinococcus granulosus | glycoprotein 3 alpha L fucosyltransferase | 0.0012 | 0.0339 | 0.1456 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0015 | 0.0476 | 0.1104 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0169 | 0.6074 | 0.5 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0012 | 0.0339 | 0.1456 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0003 | 0.0017 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0077 | 0.0429 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0169 | 0.6074 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0013 | 0.0395 | 0.103 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0046 | 0.1593 | 0.8907 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0051 | 0.1789 | 0.4657 |
Echinococcus multilocularis | alpha(13)fucosyltransferase | 0.0012 | 0.0339 | 0.1456 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0277 | 1 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0003 | 0.0017 | 0.0074 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0015 | 0.0476 | 0.5 |
Echinococcus granulosus | Immunoglobulin | 0.0003 | 0.0017 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.0017 | 0.0096 |
Echinococcus multilocularis | thymidylate synthase | 0.0032 | 0.1093 | 0.4693 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0277 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0051 | 0.0283 |
Brugia malayi | hypothetical protein | 0.0003 | 0.0017 | 0.0096 |
Brugia malayi | dihydrofolate reductase family protein | 0.0013 | 0.0395 | 0.2211 |
Onchocerca volvulus | Alpha 1,3 fucosyltransferase homolog | 0.0012 | 0.0339 | 0.2287 |
Schistosoma mansoni | vesicular amine transporter | 0.0003 | 0.0017 | 0.0045 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0108 | 0.3841 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0051 | 0.1789 | 0.4657 |
Mycobacterium leprae | 3-dehydroquinate synthase AroB | 0.0108 | 0.3841 | 0.3587 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0046 | 0.1574 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0015 | 0.0476 | 0.0232 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.2275 | 0.5923 |
Schistosoma mansoni | nephrin | 0.0004 | 0.0043 | 0.0113 |
Loa Loa (eye worm) | fucosyl transferase | 0.0051 | 0.1789 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0046 | 0.1574 | 0.5 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0051 | 0.1789 | 0.4657 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0012 | 0.0339 | 0.1456 |
Echinococcus multilocularis | alpha(13)fucosyltransferase | 0.0012 | 0.0339 | 0.1456 |
Echinococcus granulosus | twitchin | 0.0004 | 0.0043 | 0.0186 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0012 | 0.0339 | 0.0883 |
Schistosoma mansoni | cell adhesion molecule | 0.0004 | 0.0051 | 0.0132 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0003 | 0.0017 | 0.0045 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0108 | 0.3841 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0046 | 0.1574 | 0.0692 |
Mycobacterium ulcerans | thymidylate synthase | 0.0032 | 0.1093 | 0.0727 |
Echinococcus granulosus | glycoprotein 3 alpha L fucosyltransferase | 0.0012 | 0.0339 | 0.1456 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0108 | 0.3841 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1789 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.0017 | 0.0096 |
Echinococcus granulosus | roundabout 2 | 0.0004 | 0.0077 | 0.0329 |
Mycobacterium ulcerans | 3-dehydroquinate synthase | 0.0108 | 0.3841 | 0.3587 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0046 | 0.1574 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0046 | 0.1593 | 0.8907 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0003 | 0.0017 | 0.0096 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0277 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0032 | 0.1093 | 0.2847 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0012 | 0.0339 | 0.1456 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0012 | 0.0339 | 0.1456 |
Onchocerca volvulus | 0.0042 | 0.1433 | 0.9657 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 10 uM | Inhibition of human matrix metalloproteinase-8 | ChEMBL. | 12217351 |
Ki (binding) | = 12 uM | Inhibition of human matrix metalloproteinase-2 | ChEMBL. | 12217351 |
Ki (binding) | = 13 uM | Inhibition of Clostridium histolyticum collagenase | ChEMBL. | 12217351 |
Ki (binding) | = 15 uM | Inhibition of human matrix metalloproteinase-1 | ChEMBL. | 12217351 |
Ki (binding) | = 18 uM | Inhibition of human matrix metalloproteinase-9 | ChEMBL. | 12217351 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.