Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0009 | 0.0038 | 0.5 |
Schistosoma mansoni | glutaminase | 0.0131 | 0.3225 | 0.8551 |
Echinococcus granulosus | carbonic anhydrase | 0.0021 | 0.0348 | 0.1585 |
Schistosoma mansoni | carbonic anhydrase | 0.0021 | 0.0348 | 0.0924 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0009 | 0.0038 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0009 | 0.0038 | 0.1081 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0238 | 0.603 | 0.3627 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0021 | 0.0348 | 0.0924 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0092 | 0.2198 | 0.6815 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0389 | 0.9956 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0021 | 0.0348 | 0.108 |
Echinococcus granulosus | carbonic anhydrase II | 0.0092 | 0.2198 | 1 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.039 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0009 | 0.0038 | 0.0171 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0092 | 0.2198 | 0.6815 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0238 | 0.603 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0009 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0348 | 0.108 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0021 | 0.0348 | 0.108 |
Schistosoma mansoni | ap endonuclease | 0.0009 | 0.0038 | 0.01 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0238 | 0.603 | 0.6015 |
Mycobacterium ulcerans | glutaminase | 0.0131 | 0.3225 | 0.32 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0021 | 0.0348 | 0.108 |
Leishmania major | carbonic anhydrase-like protein | 0.0092 | 0.2198 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0092 | 0.2198 | 0.2208 |
Echinococcus multilocularis | carbonic anhydrase | 0.0021 | 0.0348 | 0.035 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0009 | 0.0038 | 0.0171 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0021 | 0.0348 | 0.108 |
Loa Loa (eye worm) | glutaminase | 0.0131 | 0.3225 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0092 | 0.2198 | 0.6815 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0021 | 0.0348 | 0.0924 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0092 | 0.2198 | 0.6815 |
Plasmodium falciparum | carbonic anhydrase | 0.0021 | 0.0348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0348 | 0.108 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0009 | 0.0038 | 0.01 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0009 | 0.0038 | 0.0171 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0009 | 0.0038 | 0.0117 |
Loa Loa (eye worm) | glutaminase 2 | 0.0131 | 0.3225 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0009 | 0.0038 | 0.0171 |
Echinococcus multilocularis | carbonic anhydrase | 0.0021 | 0.0348 | 0.035 |
Echinococcus multilocularis | carbonic anhydrase | 0.0021 | 0.0348 | 0.035 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0152 | 0.3772 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0092 | 0.2198 | 0.5828 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0238 | 0.603 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0009 | 0.0038 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0021 | 0.0348 | 0.1585 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0092 | 0.2198 | 1 |
Mycobacterium ulcerans | 3-dehydroquinate synthase | 0.0152 | 0.3772 | 0.3748 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0348 | 0.108 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0009 | 0.0038 | 0.0117 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0009 | 0.0038 | 0.0171 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0021 | 0.0348 | 0.108 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.039 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0021 | 0.0348 | 0.1585 |
Toxoplasma gondii | hypothetical protein | 0.0021 | 0.0348 | 0.0348 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0152 | 0.3772 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0131 | 0.3225 | 1 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0152 | 0.3772 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0021 | 0.0348 | 0.0924 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.039 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0348 | 0.0924 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0021 | 0.0348 | 0.108 |
Toxoplasma gondii | exonuclease III APE | 0.0009 | 0.0038 | 0.0038 |
Schistosoma mansoni | ap endonuclease | 0.0009 | 0.0038 | 0.01 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0092 | 0.2198 | 0.5828 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0092 | 0.2198 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0131 | 0.3225 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0092 | 0.2198 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Effect (functional) | 0 | Evaluated for antiviral activity against cutaneous HSV-1 C42 infections in guinea pig; Not active | ChEMBL. | 6298425 |
IC50 (binding) | > 500 uM | Inhibition of HSV-1 DNA polymerase in HSV-1 C42 plaque reduction assay | ChEMBL. | 6298425 |
IC50 (binding) | > 500 uM | Inhibition of HSV-1 DNA polymerase in HSV-1 C42 plaque reduction assay | ChEMBL. | 6298425 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.