Detailed information for compound 1493104

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 333.464 | Formula: C17H35NO5
  • H donors: 4 H acceptors: 4 LogP: 1.38 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCOCCCCCN1C[C@H](O)[C@H]([C@@H]([C@@H]1CO)O)O
  • InChi: 1S/C17H35NO5/c1-2-3-4-7-10-23-11-8-5-6-9-18-12-15(20)17(22)16(21)14(18)13-19/h14-17,19-22H,2-13H2,1H3/t14-,15-,16+,17+/m0/s1
  • InChiKey: RCXJPSZNTHETPE-MWDXBVQZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus UDP-glucose ceramide glucosyltransferase Starlite/ChEMBL References
Homo sapiens glucosidase, beta (bile acid) 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Schistosoma japonicum Ceramide glucosyltransferase, putative Get druggable targets OG5_129848 All targets in OG5_129848
Schistosoma mansoni bile acid beta-glucosidase-related Get druggable targets OG5_130651 All targets in OG5_130651
Echinococcus multilocularis ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Schistosoma mansoni ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Echinococcus multilocularis bile acid beta glucosidase Get druggable targets OG5_130651 All targets in OG5_130651
Loa Loa (eye worm) ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Onchocerca volvulus Ceramide glucosyltransferase homolog Get druggable targets OG5_129848 All targets in OG5_129848
Echinococcus granulosus ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Schistosoma japonicum ko:K00720 ceramide glucosyltransferase [EC2.4.1.80], putative Get druggable targets OG5_129848 All targets in OG5_129848
Schistosoma japonicum Non-lysosomal glucosylceramidase, putative Get druggable targets OG5_130651 All targets in OG5_130651
Schistosoma japonicum Non-lysosomal glucosylceramidase, putative Get druggable targets OG5_130651 All targets in OG5_130651
Candida albicans ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Schistosoma japonicum Non-lysosomal glucosylceramidase, putative Get druggable targets OG5_130651 All targets in OG5_130651
Echinococcus multilocularis non lysosomal glucosylceramidase Get druggable targets OG5_130651 All targets in OG5_130651
Schistosoma mansoni bile acid beta-glucosidase-related Get druggable targets OG5_130651 All targets in OG5_130651
Brugia malayi Ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Schistosoma mansoni ceramide glucosyltransferase Get druggable targets OG5_129848 All targets in OG5_129848
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130651 All targets in OG5_130651
Echinococcus granulosus non lysosomal glucosylceramidase Get druggable targets OG5_130651 All targets in OG5_130651
Echinococcus granulosus bile acid beta glucosidase Get druggable targets OG5_130651 All targets in OG5_130651
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0655 0.0702
Schistosoma mansoni importin beta-1 0.0029 0.01 0.0236
Loa Loa (eye worm) hypothetical protein 0.0033 0.0138 0.0134
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0278 0.0274
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.002 0.0258
Echinococcus multilocularis muscleblind protein 0.0295 0.3262 0.3515
Schistosoma mansoni ceramide glucosyltransferase 0.0288 0.3185 0.7819
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0792 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0792 1
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.035
Echinococcus multilocularis GPCR, family 2 0.0033 0.0147 0.0154
Echinococcus granulosus importin subunit beta 1 0.0029 0.01 0.0216
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.007 0.0582 0.7357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0201 0.2461
Brugia malayi ADAMTS-like protease 0.0264 0.2894 0.2891
Brugia malayi beta-lactamase family protein 0.0035 0.0173 0.0169
Schistosoma mansoni hypothetical protein 0.0072 0.0607 0.1481
Brugia malayi beta-lactamase 0.0035 0.0173 0.0169
Schistosoma mansoni alpha-glucosidase 0.0339 0.3789 0.9303
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0102
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0147 0.0154
Entamoeba histolytica hypothetical protein 0.0024 0.0034 0.0334
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0169
Trichomonas vaginalis hypothetical protein 0.0034 0.0162 0.1959
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.035
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0173 0.2108
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0278 0.3445
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.001 0.0019
Brugia malayi hypothetical protein 0.0246 0.2689 0.2685
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0147 0.0321
Toxoplasma gondii ABC1 family protein 0.0035 0.0173 0.2108
Leishmania major alpha glucosidase II subunit, putative 0.0087 0.0792 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0022 0.001 0.0019
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0147 0.0154
Brugia malayi Ceramide glucosyltransferase 0.0288 0.3185 0.3182
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1004 0.1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Echinococcus granulosus snurportin 1 0.0313 0.3487 0.7846
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.001 0.0019
Echinococcus multilocularis lysosomal alpha glucosidase 0.0393 0.4443 0.4789
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0173 0.2108
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0022 0.001 0.0019
Brugia malayi RNA, U transporter 1 0.0083 0.0746 0.0741
Toxoplasma gondii peptidylprolyl isomerase 0.007 0.0582 0.733
Brugia malayi beta-lactamase family protein 0.0035 0.0173 0.0169
Schistosoma mansoni hypothetical protein 0.0362 0.4073 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0087 0.0792 0.0849
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.007 0.0582 0.733
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0071 0.0595 0.1329
Loa Loa (eye worm) hypothetical protein 0.0246 0.2689 0.2685
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0033 0.0138 0.1662
Loa Loa (eye worm) hypothetical protein 0.0271 0.2986 0.2983
Trichomonas vaginalis maltase-glucoamylase, putative 0.0087 0.0792 1
Loa Loa (eye worm) reprolysin 0.0116 0.1139 0.1135
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0034 0.0334
Brugia malayi hypothetical protein 0.0071 0.0595 0.059
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0169
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.007 0.0582 0.733
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0393 0.4443 0.444
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.01 0.1179
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0173 0.5
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0116 0.1139 0.2789
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0071 0.0603 0.0598
Echinococcus multilocularis geminin 0.0362 0.4073 0.439
Loa Loa (eye worm) hypothetical protein 0.0116 0.1139 0.1135
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0116 0.1139 0.2789
Brugia malayi hypothetical protein 0.0076 0.0655 0.0651
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0278 0.0295
Plasmodium vivax importin-beta 2, putative 0.0029 0.01 0.5594
Echinococcus granulosus lysosomal alpha glucosidase 0.0393 0.4443 1
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0048 0.0325 0.4039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0173 0.0415
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0169
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0087 0.0792 1
Trichomonas vaginalis rotamase, putative 0.0071 0.0603 0.7586
Loa Loa (eye worm) hypothetical protein 0.0105 0.1004 0.1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0348
Schistosoma mansoni ran 0.0022 0.0008 0.0009
Echinococcus granulosus adam 0.0246 0.2689 0.6048
Schistosoma mansoni tsg101-related 0.0059 0.0453 0.1103
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1004 0.1
Brugia malayi Muscleblind-like protein 0.0295 0.3262 0.3259
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0138 0.1662
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.007 0.0582 0.733
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0116 0.1139 0.2789
Loa Loa (eye worm) hypothetical protein 0.0071 0.0595 0.059
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0138 0.1662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0278 0.3445
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.01 0.1269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0063 0.0696
Echinococcus multilocularis expressed protein 0.0071 0.0603 0.0645
Brugia malayi Glycosyl hydrolases family 31 protein 0.0393 0.4443 0.444
Trichomonas vaginalis sucrase-isomaltase, putative 0.0087 0.0792 1
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0655 0.1599
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0171 0.2073
Leishmania major hypothetical protein, conserved 0.0023 0.002 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.2068
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0056 0.0713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0066 0.0736
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0359 0.4032 0.4346
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0278 0.3445
Schistosoma mansoni bile acid beta-glucosidase-related 0.0251 0.2748 0.6743
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.035
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0792 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0607 0.0603
Echinococcus multilocularis muscleblind protein 1 0.0295 0.3262 0.3515
Loa Loa (eye worm) hypothetical protein 0.0295 0.3262 0.3259
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0087 0.0792 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0008 0.0004
Echinococcus multilocularis snurportin 1 0.0313 0.3487 0.3757
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0087 0.0792 1
Leishmania major hypothetical protein, conserved 0.0026 0.0056 0.0617
Brugia malayi Importin beta-1 subunit 0.0029 0.01 0.0096
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0033 0.0138 0.1662
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0278 0.3512
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0278 0.3445
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0033 0.0138 0.0149
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0138 0.1662
Brugia malayi angiogenesis inhibito 0.0264 0.2894 0.2891
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.2068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Giardia lamblia GTOR 0.0044 0.0278 0.2077
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0022 0.001 0.0121
Echinococcus granulosus ceramide glucosyltransferase 0.0288 0.3185 0.7167
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0173 0.0169
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.9272 1
Leishmania major hypothetical protein, conserved 0.0035 0.0173 0.2108
Entamoeba histolytica hypothetical protein 0.0076 0.0655 0.8255
Plasmodium falciparum importin beta, putative 0.0029 0.01 1
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0246 0.2689 0.6597
Mycobacterium ulcerans beta-lactamase 0.0035 0.0173 0.5
Echinococcus multilocularis lysosomal alpha glucosidase 0.0393 0.4443 0.4789
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0169
Loa Loa (eye worm) hypothetical protein 0.0775 0.8986 0.8986
Onchocerca volvulus 0.0228 0.2464 0.2739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.2068
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.01 0.1269
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0288 0.3185 0.3541
Echinococcus granulosus GPCR family 2 0.0033 0.0147 0.0321
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0173 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.2068
Loa Loa (eye worm) hypothetical protein 0.0295 0.3262 0.3259
Schistosoma mansoni alpha-glucosidase 0.0339 0.3789 0.9303
Mycobacterium leprae Probable lipase LipE 0.0035 0.0173 0.5
Loa Loa (eye worm) metalloprotease 0.0116 0.1139 0.1135
Brugia malayi Reprolysin 0.0116 0.1139 0.1135
Brugia malayi Glycosyl hydrolases family 31 protein 0.0087 0.0792 0.0787
Trypanosoma brucei glucosidase, putative 0.0087 0.0792 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0087 0.0792 0.0787
Schistosoma mansoni tsg101-related 0.0048 0.0325 0.0787
Loa Loa (eye worm) beta-lactamase 0.0035 0.0173 0.0169
Echinococcus granulosus non lysosomal glucosylceramidase 0.0251 0.2748 0.6181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0278 0.3445
Schistosoma mansoni hypothetical protein 0.0362 0.4073 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0143 0.172
Trypanosoma brucei glycosyl hydrolase-like protein 0.0033 0.0138 0.1747
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0056 0.0617
Loa Loa (eye worm) hypothetical protein 0.0116 0.1139 0.1135
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0056 0.5234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0173 0.2108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0343
Entamoeba histolytica hypothetical protein 0.0076 0.0655 0.8255
Mycobacterium ulcerans hypothetical protein 0.0035 0.0173 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0066 0.0736
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0169
Schistosoma mansoni alpha glucosidase 0.0087 0.0792 0.1935
Mycobacterium ulcerans lipase LipD 0.0035 0.0173 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2451 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0173 0.2108
Loa Loa (eye worm) ceramide glucosyltransferase 0.0288 0.3185 0.3182
Trichomonas vaginalis maltase-glucoamylase, putative 0.0033 0.0138 0.1662
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0603 0.7586
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0278 0.0616
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0173 0.2108
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0071 0.0595 0.0637
Echinococcus granulosus neutral alpha glucosidase AB 0.0087 0.0792 0.1774
Brugia malayi hypothetical protein 0.0775 0.8986 0.8986
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0116 0.1139 0.2557
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0278 0.3512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.002 0.0158
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0022 0.001 0.5
Brugia malayi hypothetical protein 0.0026 0.0056 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1004 0.1
Echinococcus granulosus bile acid beta glucosidase 0.0251 0.2748 0.6181
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0173 0.2189
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0147 0.0143
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0173 0.2108
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0278 0.0274
Onchocerca volvulus 0.0035 0.0173 0.0188
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0008 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0792 1
Echinococcus granulosus muscleblind protein 0.0295 0.3262 0.7341
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0056 0.5234
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0655 0.1465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0348
Schistosoma mansoni ceramide glucosyltransferase 0.0288 0.3185 0.7819
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.0792 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0173 0.038
Brugia malayi metalloprotease 0.0116 0.1139 0.1135
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0056 0.0617
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0138 0.1662
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0034 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0093 0.1083
Entamoeba histolytica hypothetical protein 0.0076 0.0655 0.8255
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0792 1
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0359 0.4032 0.9074
Schistosoma mansoni hypothetical protein 0.0033 0.0147 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0066 0.0736
Echinococcus multilocularis ceramide glucosyltransferase 0.0288 0.3185 0.3432
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0173 0.0169
Echinococcus granulosus geminin 0.0362 0.4073 0.9167
Leishmania major importin beta-1 subunit, putative 0.0024 0.0034 0.0334
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.3487 0.3484
Entamoeba histolytica hypothetical protein 0.0076 0.0655 0.8255
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0138 0.1662
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0173 0.0415
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0171 0.2073
Loa Loa (eye worm) hypothetical protein 0.0033 0.0147 0.0143
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0173 0.2108
Echinococcus multilocularis non lysosomal glucosylceramidase 0.0251 0.2748 0.296
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0104 0.1229
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0173 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0034 0.0334
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0003
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0056 0.0617
Schistosoma mansoni tsg101-related 0.0059 0.0453 0.1103
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0087 0.0792 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0173 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0607 0.0603
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0278 0.3445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0343
Echinococcus multilocularis importin subunit beta 1 0.0029 0.01 0.0103
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0171 0.2154
Onchocerca volvulus 0.0035 0.0173 0.0188
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0359 0.4032 0.9899
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0147 0.0143
Loa Loa (eye worm) hypothetical protein 0.0029 0.01 0.0096
Echinococcus granulosus expressed protein 0.0071 0.0603 0.1347
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0278 0.3445
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0169
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0278 0.3445
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0116 0.1139 0.1224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0063 0.0696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Trichomonas vaginalis rotamase, putative 0.007 0.0582 0.733
Onchocerca volvulus 0.0035 0.0173 0.0188
Echinococcus multilocularis bile acid beta glucosidase 0.0251 0.2748 0.296
Onchocerca volvulus 0.0775 0.8986 1
Schistosoma mansoni hypothetical protein 0.0076 0.0655 0.1599
Brugia malayi Glycosyl hydrolases family 31 protein 0.0033 0.0138 0.0134
Echinococcus multilocularis adam 0.0246 0.2689 0.2896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.2068
Trichomonas vaginalis esterase, putative 0.0035 0.0173 0.2108
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0087 0.0792 1
Schistosoma mansoni hypothetical protein 0.0313 0.3487 0.8559
Loa Loa (eye worm) hypothetical protein 0.013 0.13 0.1296
Loa Loa (eye worm) hypothetical protein 0.086 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0278 0.0672
Schistosoma mansoni ran 0.0022 0.0008 0.0009
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0034 0.0334
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0138 0.1662
Leishmania major glycosyl hydrolase-like protein 0.0033 0.0138 0.1662
Trichomonas vaginalis alpha-glucosidase, putative 0.0087 0.0792 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0052
Schistosoma mansoni bile acid beta-glucosidase-related 0.0251 0.2748 0.6743
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0071 0.0603 0.0598
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0138 0.1662
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0138 0.1662
Loa Loa (eye worm) angiogenesis inhibito 0.0134 0.1345 0.1341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0348
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0173 0.5
Onchocerca volvulus Papilin homolog 0.0271 0.2986 0.332
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0147 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0278 0.3445
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.007 0.0582 0.733
Schistosoma mansoni rotamase 0.0071 0.0603 0.147
Loa Loa (eye worm) hypothetical protein 0.017 0.1774 0.177
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0056 0.2928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0143 0.172
Giardia lamblia Ceramide glucosyltransferase 0.0131 0.1308 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0147 0.0321

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.025 uM Inhibition of recombinant GBA2 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay ChEMBL. 24900289
IC50 (binding) = 0.1 uM Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay ChEMBL. 24900289
IC50 (binding) = 95 uM Inhibition of recombinant GBA1 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay ChEMBL. 24900289
IC50 (binding) = 200 uM Inhibition of lactase in mouse intestinal input by glucose release assay ChEMBL. 24900289
IC50 (binding) > 1000 uM Inhibition of maltase in mouse intestinal input by glucose release assay ChEMBL. 24900289
IC50 (binding) > 1000 uM Inhibition of sucrase in mouse intestinal input by glucose release assay ChEMBL. 24900289

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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