Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | acyl-CoA synthetase | 0.0069 | 0.1486 | 0.5 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.012 | 0.5884 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0131 | 0.6788 | 0.524 |
Loa Loa (eye worm) | Ulp1 protease | 0.009 | 0.3253 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0103 | 0.4388 | 0.1683 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0169 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.012 | 0.5884 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.009 | 0.3253 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.012 | 0.5884 | 0.5 |
Loa Loa (eye worm) | ILVBL protein | 0.0073 | 0.1828 | 0.189 |
Mycobacterium ulcerans | hypothetical protein | 0.012 | 0.5884 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.012 | 0.5884 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.009 | 0.3253 | 0.5 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.012 | 0.5884 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.009 | 0.3253 | 0.5 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.012 | 0.5884 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.0131 | 0.6788 | 0.524 |
Schistosoma mansoni | acetolactate synthase | 0.0103 | 0.4388 | 0.1683 |
Trichomonas vaginalis | Sentrin-specific protease, putative | 0.009 | 0.3253 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0069 | 0.1486 | 0.5 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0169 | 1 | 1 |
Echinococcus multilocularis | sentrin specific protease 7 | 0.0169 | 1 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.009 | 0.3253 | 0.5 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.012 | 0.5884 | 0.5 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0069 | 0.1486 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.