Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0899 | 1 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.0857 | 0.0722 |
Leishmania major | phosphonopyruvate decarboxylase-like protein | 0.029 | 0.2955 | 0.5325 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.016 | 0.1446 | 0.2451 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0899 | 1 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.0857 | 0.0722 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.0146 | 0.0244 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0122 | 0.0999 | 0.0866 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0899 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.0146 | 0.0486 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.016 | 0.1441 | 0.0378 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0899 | 1 | 1 |
Treponema pallidum | pyruvate oxidoreductase | 0.0131 | 0.1104 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0002 | 0.0018 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.029 | 0.2955 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0051 | 0.0186 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0158 | 0.0265 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0514 | 0.5547 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0122 | 0.0999 | 0.0866 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0131 | 0.1104 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.0857 | 0.0722 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0158 | 0.0158 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0002 | 0.0012 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0158 | 0.0265 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0514 | 0.5547 | 0.4994 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.0146 | 0.0486 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.0857 | 0.0722 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0122 | 0.0999 | 0.0155 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0002 | 0.0018 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.016 | 0.1446 | 0.8783 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0002 | 0.0012 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.1187 | 0.1399 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.016 | 0.1446 | 0.1446 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0131 | 0.1104 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.0857 | 0.0722 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0131 | 0.1104 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0514 | 0.5547 | 0.4994 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.029 | 0.2955 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0002 | 0.0002 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0002 | 0.0002 |
Mycobacterium tuberculosis | Probable oxidoreductase (beta subunit) | 0.0131 | 0.1104 | 0.0973 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0514 | 0.5547 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.0146 | 0.0885 |
Mycobacterium ulcerans | hypothetical protein | 0.0899 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.0146 | 0.0244 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0131 | 0.1104 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.1646 | 0.194 |
Echinococcus multilocularis | geminin | 0.0177 | 0.1646 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.1187 | 0.1399 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.0146 | 1 |
Onchocerca volvulus | 0.0093 | 0.0664 | 0.5 | |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0131 | 0.1104 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0899 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.1446 | 0.8783 |
Echinococcus granulosus | geminin | 0.0177 | 0.1646 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0515 | 0.5557 | 0.9429 |
Schistosoma mansoni | acetolactate synthase | 0.0768 | 0.8486 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.029 | 0.2955 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0158 | 0.0158 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0131 | 0.1104 | 0.5 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SH | 0.016 | 0.1441 | 0.0638 |
Mycobacterium ulcerans | acetolactate synthase | 0.0514 | 0.5547 | 0.4994 |
Brugia malayi | glutathione reductase | 0.0048 | 0.0146 | 0.0146 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.0146 | 0.0885 |
Brugia malayi | Cytochrome P450 family protein | 0.0051 | 0.0186 | 0.0186 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.029 | 0.2955 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.1646 | 0.194 |
Mycobacterium ulcerans | hypothetical protein | 0.029 | 0.2955 | 0.208 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0514 | 0.5547 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0122 | 0.0999 | 0.0866 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 0.1446 | 0.8783 |
Loa Loa (eye worm) | ILVBL protein | 0.0544 | 0.5893 | 1 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0384 | 0.4043 | 0.3955 |
Schistosoma mansoni | acetolactate synthase | 0.0768 | 0.8486 | 1 |
Leishmania major | trypanothione reductase | 0.0048 | 0.0146 | 0.0259 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.0857 | 0.0722 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0899 | 1 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0131 | 0.1104 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0131 | 0.1104 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.