Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0136 | 0.0462 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0112 | 0.1033 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.077 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0164 | 0.1741 | 0.2968 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.077 | 1 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0112 | 0.1033 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0002 | 0.0013 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0249 | 0.2898 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.0943 | 0.0818 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.077 | 1 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0249 | 0.2898 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0164 | 0.1741 | 0.1741 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.0943 | 0.0818 |
Mycobacterium ulcerans | hypothetical protein | 0.077 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0136 | 0.0228 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.019 | 0.0321 |
Mycobacterium ulcerans | acetolactate synthase | 0.0441 | 0.5511 | 0.4994 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.1103 | 0.098 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0112 | 0.1033 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0136 | 0.0744 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0053 | 0.0224 | 0.0378 |
Mycobacterium tuberculosis | Probable oxidoreductase (beta subunit) | 0.0112 | 0.1033 | 0.0909 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0002 | 0.0013 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0164 | 0.1741 | 0.9511 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0137 | 0.1372 | 0.0378 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0002 | 0.0003 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.143 | 0.1687 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.0943 | 0.0818 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.019 | 0.019 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0002 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.019 | 0.0321 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0441 | 0.5511 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0136 | 0.0462 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.0943 | 0.0818 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0002 | 0.0023 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0002 | 0.0002 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0112 | 0.1033 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0136 | 0.0744 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0441 | 0.5511 | 0.4994 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.077 | 1 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0112 | 0.1033 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0136 | 0.0136 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.183 | 0.216 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.183 | 0.216 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.1103 | 0.0177 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.0943 | 0.0818 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0112 | 0.1033 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0249 | 0.2898 | 0.208 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0441 | 0.5511 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.1741 | 0.9511 |
Echinococcus granulosus | geminin | 0.0171 | 0.183 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0441 | 0.5522 | 0.9422 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SH | 0.0137 | 0.1372 | 0.0474 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0136 | 0.0243 |
Onchocerca volvulus | 0.0095 | 0.0799 | 0.5 | |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0112 | 0.1033 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.077 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.1103 | 0.098 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.143 | 0.1687 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0441 | 0.5511 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0249 | 0.2898 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0658 | 0.8474 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.019 | 0.019 |
Treponema pallidum | pyruvate oxidoreductase | 0.0112 | 0.1033 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.1741 | 0.9511 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0136 | 0.0228 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0136 | 0.0136 |
Brugia malayi | Cytochrome P450 family protein | 0.0053 | 0.0224 | 0.0224 |
Echinococcus multilocularis | geminin | 0.0171 | 0.183 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0249 | 0.2898 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0441 | 0.5511 | 0.4994 |
Leishmania major | phosphonopyruvate decarboxylase-like protein | 0.0249 | 0.2898 | 0.5257 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.1103 | 0.098 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0112 | 0.1033 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0466 | 0.586 | 1 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0329 | 0.3995 | 0.3912 |
Schistosoma mansoni | acetolactate synthase | 0.0658 | 0.8474 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0136 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.0943 | 0.0818 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.077 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.