Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | acetolactate synthase | 0.0384 | 0.8371 | 1 |
Echinococcus multilocularis | geminin | 0.0177 | 0.3231 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0257 | 0.5222 | 0.9352 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.1532 | 0.1532 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0065 | 0.0433 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.1532 | 0.1532 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0257 | 0.5211 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0449 | 1 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0065 | 0.0433 | 0.5 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0109 | 0.1532 | 0.0802 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0449 | 1 | 1 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0449 | 1 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.1532 | 0.1532 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0145 | 0.2423 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0257 | 0.5211 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.3231 | 0.1066 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0122 | 0.1837 | 0.1837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0122 | 0.1837 | 0.1132 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0449 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase (beta subunit) | 0.0065 | 0.0433 | 0.0433 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0065 | 0.0433 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0449 | 1 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0145 | 0.2423 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0449 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0257 | 0.5211 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.3231 | 0.1066 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.1532 | 0.1532 |
Loa Loa (eye worm) | ILVBL protein | 0.0272 | 0.5583 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0065 | 0.0433 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0384 | 0.8371 | 1 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0192 | 0.3593 | 0.3593 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0065 | 0.0433 | 0.5 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0145 | 0.2423 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0145 | 0.2423 | 1 |
Treponema pallidum | pyruvate oxidoreductase | 0.0065 | 0.0433 | 0.5 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0065 | 0.0433 | 0.5 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.008 | 0.0794 | 0.0378 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0449 | 1 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0257 | 0.5211 | 0.4994 |
Mycobacterium ulcerans | acetolactate synthase | 0.0257 | 0.5211 | 0.4994 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0257 | 0.5211 | 0.4994 |
Mycobacterium ulcerans | hypothetical protein | 0.0145 | 0.2423 | 0.208 |
Echinococcus granulosus | geminin | 0.0177 | 0.3231 | 1 |
Leishmania major | phosphonopyruvate decarboxylase-like protein | 0.0145 | 0.2423 | 0.4649 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.1532 | 0.1532 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0065 | 0.0433 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.1532 | 0.1532 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0122 | 0.1837 | 0.1837 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0065 | 0.0433 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0122 | 0.1837 | 0.1837 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 2.1 ug ml-1 | Cytotoxicity against human KB cells assessed as inhibition of protein biosynthesis | ChEMBL. | 21194944 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.