Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | acyl-CoA synthetase | 0.0257 | 0.5211 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.3231 | 0.1066 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0449 | 1 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0272 | 0.5583 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.1532 | 0.1532 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0192 | 0.3593 | 0.3593 |
Schistosoma mansoni | acetolactate synthase | 0.0384 | 0.8371 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0065 | 0.0433 | 0.5 |
Treponema pallidum | pyruvate oxidoreductase | 0.0065 | 0.0433 | 0.5 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0145 | 0.2423 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0065 | 0.0433 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0145 | 0.2423 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0065 | 0.0433 | 0.5 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.008 | 0.0794 | 0.0378 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0449 | 1 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0257 | 0.5211 | 0.4994 |
Mycobacterium ulcerans | acetolactate synthase | 0.0257 | 0.5211 | 0.4994 |
Mycobacterium ulcerans | hypothetical protein | 0.0145 | 0.2423 | 0.208 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0257 | 0.5211 | 0.4994 |
Echinococcus granulosus | geminin | 0.0177 | 0.3231 | 1 |
Leishmania major | phosphonopyruvate decarboxylase-like protein | 0.0145 | 0.2423 | 0.4649 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.1532 | 0.1532 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.1532 | 0.1532 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0065 | 0.0433 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0122 | 0.1837 | 0.1837 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0065 | 0.0433 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0122 | 0.1837 | 0.1837 |
Echinococcus multilocularis | geminin | 0.0177 | 0.3231 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0384 | 0.8371 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0257 | 0.5222 | 0.9352 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.1532 | 0.1532 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0257 | 0.5211 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.1532 | 0.1532 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0065 | 0.0433 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0 | 0.5 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0065 | 0.0433 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0449 | 1 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0109 | 0.1532 | 0.0802 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0449 | 1 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0145 | 0.2423 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.1532 | 0.1532 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0449 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0257 | 0.5211 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.3231 | 0.1066 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0449 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase (beta subunit) | 0.0065 | 0.0433 | 0.0433 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0122 | 0.1837 | 0.1837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0122 | 0.1837 | 0.1132 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0145 | 0.2423 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0449 | 1 | 1 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0065 | 0.0433 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 3.9 ug ml-1 | Cytotoxicity against human KB cells assessed as inhibition of protein biosynthesis | ChEMBL. | 21194944 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.