Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cytochrome b | 0.0511 | 0.263 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.0202 | 0.0176 |
Schistosoma mansoni | ets-related | 0.0224 | 0.1006 | 0.343 |
Brugia malayi | cytochrome b | 0.0312 | 0.1506 | 1 |
Mycobacterium tuberculosis | Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) | 0.1815 | 1 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.0202 | 1 |
Plasmodium vivax | cytochrome b | 0.0511 | 0.263 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0049 | 0.002 | 0.002 |
Onchocerca volvulus | 0.1815 | 1 | 1 | |
Echinococcus granulosus | cytochrome B | 0.0511 | 0.263 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.002 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0098 | 0.0652 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0074 | 0.0159 | 0.1053 |
Toxoplasma gondii | apocytochrome b, putative | 0.0511 | 0.263 | 1 |
Loa Loa (eye worm) | cytochrome b | 0.0312 | 0.1506 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0081 | 0.0202 | 0.1342 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0511 | 0.263 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.0202 | 0.0176 |
Schistosoma mansoni | cytochrome b | 0.0511 | 0.263 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.0202 | 1 |
Schistosoma mansoni | cytochrome b | 0.0312 | 0.1506 | 0.5452 |
Mycobacterium ulcerans | ubiquinol-cytochrome C reductase QcrB | 0.1815 | 1 | 0.5 |
Brugia malayi | Fli-1 protein | 0.0224 | 0.1006 | 0.6682 |
Toxoplasma gondii | cytochrome b | 0.0511 | 0.263 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.0202 | 0.0176 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.0202 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.0202 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0074 | 0.0159 | 0.1053 |
Loa Loa (eye worm) | fli-1 protein | 0.0224 | 0.1006 | 0.6682 |
Brugia malayi | Heterochromatin protein 1 | 0.0081 | 0.0202 | 0.1342 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.0202 | 0.0176 |
Brugia malayi | Ets-domain containing protein | 0.0074 | 0.0159 | 0.1053 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.002 | 0.0969 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.6 uM | Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxis | ChEMBL. | 21341682 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.