Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor subunit alpha-6 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0338 | 0.4844 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0191 | 0.1842 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0201 | 0.2059 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.059 | 1 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0338 | 0.4844 | 0.4798 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0201 | 0.2059 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase | 0.0338 | 0.4844 | 0.4798 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0191 | 0.1842 | 0.5 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.059 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0201 | 0.2059 | 0.3927 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0201 | 0.2059 | 0.3927 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.059 | 1 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0338 | 0.4855 | 0.9258 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.059 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0201 | 0.2059 | 0.2059 |
Mycobacterium ulcerans | hypothetical protein | 0.0191 | 0.1842 | 0.1769 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0191 | 0.1842 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.2059 | 0.3927 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.2059 | 0.3927 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0338 | 0.4844 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0504 | 0.8247 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0357 | 0.5245 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0191 | 0.1842 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0201 | 0.2059 | 0.3927 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.059 | 1 | 1 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.059 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.059 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0201 | 0.2059 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0338 | 0.4844 | 0.4798 |
Onchocerca volvulus | 0.0201 | 0.2059 | 1 | |
Schistosoma mansoni | acetolactate synthase | 0.0504 | 0.8247 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0338 | 0.4844 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.2059 | 0.3927 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.22 nM | Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release | ChEMBL. | 21147530 |
Imax (functional) | = 67 % | Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release relative to nicotine | ChEMBL. | 21147530 |
Inhibition (functional) | = 83 % | Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release at 100 nM relative to control | ChEMBL. | 21147530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.