Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.2472 | 0.2472 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.2062 | 0.1684 |
Mycobacterium ulcerans | hypothetical protein | 0.0334 | 1 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0334 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.2062 | 0.2062 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0334 | 1 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0049 | 0.0079 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0334 | 1 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0108 | 0.2143 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0049 | 0.0079 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase (beta subunit) | 0.0049 | 0.0079 | 0.0079 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0334 | 1 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0108 | 0.2143 | 1 |
Leishmania major | phosphonopyruvate decarboxylase-like protein | 0.0108 | 0.2143 | 0.4257 |
Echinococcus multilocularis | geminin | 0.0167 | 0.4205 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0191 | 0.5034 | 1 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0143 | 0.3357 | 0.3357 |
Schistosoma mansoni | acetolactate synthase | 0.0285 | 0.8311 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0191 | 0.5034 | 0.4994 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.2062 | 0.2062 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0 | 0.5 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0049 | 0.0079 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.2062 | 0.2062 |
Mycobacterium ulcerans | acetolactate synthase | 0.0191 | 0.5034 | 0.4994 |
Echinococcus granulosus | geminin | 0.0167 | 0.4205 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0108 | 0.2143 | 0.208 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.2472 | 0.2472 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0191 | 0.5034 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0191 | 0.5034 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0108 | 0.2143 | 1 |
Treponema pallidum | pyruvate oxidoreductase | 0.0049 | 0.0079 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0108 | 0.2143 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.2062 | 0.2062 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.2062 | 0.2062 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0049 | 0.0079 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.4205 | 0.1423 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0049 | 0.0079 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0285 | 0.8311 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0202 | 0.542 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.2062 | 0.2062 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0191 | 0.5045 | 0.9308 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.4205 | 0.1423 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0334 | 1 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0334 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0191 | 0.5034 | 0.4994 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0059 | 0.0454 | 0.0378 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0049 | 0.0079 | 0.5 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0049 | 0.0079 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.2472 | 0.2114 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.2472 | 0.2472 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0049 | 0.0079 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 60.1 uM | Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay | ChEMBL. | 21093116 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.