Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Echinococcus multilocularis | conserved hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0325 | 0.3495 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0486 | 0.5517 | 1 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0569 | 0.6559 | 1 |
Echinococcus multilocularis | geminin | 0.0177 | 0.1631 | 0.1649 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0101 | 0.0669 | 0.0378 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0569 | 0.6559 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0083 | 0.0438 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0122 | 0.0927 | 0.1414 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.1631 | 0.0738 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0083 | 0.0438 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0569 | 0.6559 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0184 | 0.1711 | 0.208 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0569 | 0.6559 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0122 | 0.0927 | 0.1414 |
Mycobacterium tuberculosis | Probable oxidoreductase (beta subunit) | 0.0083 | 0.0438 | 0.0668 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.0774 | 0.1179 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.9892 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0486 | 0.5517 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0122 | 0.0927 | 0.1414 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0326 | 0.3502 | 0.938 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.0774 | 0.1179 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0083 | 0.0438 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.0774 | 0.1179 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0569 | 0.6559 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0184 | 0.1711 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.1631 | 0.0738 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0109 | 0.0774 | 0.0177 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0122 | 0.0927 | 0.0438 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0083 | 0.0438 | 0.5 |
Echinococcus granulosus | geminin | 0.0177 | 0.1631 | 0.1631 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0083 | 0.0438 | 0.5 |
Leishmania major | phosphonopyruvate decarboxylase-like protein | 0.0184 | 0.1711 | 0.4896 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0325 | 0.3495 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0325 | 0.3495 | 0.4994 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0184 | 0.1711 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0325 | 0.3495 | 0.4994 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.0774 | 0.1179 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0184 | 0.1711 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0083 | 0.0438 | 0.5 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0184 | 0.1711 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0569 | 0.6559 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0325 | 0.3495 | 0.4994 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0083 | 0.0438 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.0774 | 0.1179 |
Loa Loa (eye worm) | ILVBL protein | 0.0344 | 0.3733 | 1 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0243 | 0.246 | 0.3751 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0569 | 0.6559 | 1 |
Treponema pallidum | pyruvate oxidoreductase | 0.0083 | 0.0438 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0325 | 0.3495 | 1 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0083 | 0.0438 | 0.5 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0569 | 0.6559 | 1 |
Brugia malayi | Serotonin receptor | 0.0564 | 0.6502 | 0.9913 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.0774 | 0.1179 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 63 nM | Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay | ChEMBL. | 21146986 |
EC50 (functional) | = 211 nM | Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay | ChEMBL. | 21146986 |
EC50 (functional) | = 1478 nM | Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay | ChEMBL. | 21146986 |
Emax (functional) | = 73 % | Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay relative to 5-HT | ChEMBL. | 21146986 |
Emax (functional) | = 94 % | Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay relative to 5-HT | ChEMBL. | 21146986 |
Emax (functional) | = 99 % | Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay relative to 5-HT | ChEMBL. | 21146986 |
Inhibition (binding) | Inhibition of human ERG expressed in CHO cells at 10 uM by whole cell patch-clamp technique | ChEMBL. | 21146986 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.