Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Echinococcus multilocularis | conserved hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Echinococcus granulosus | hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0174 | 0.1596 | 0.1596 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0098 | 0.0642 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1596 | 0.056 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0098 | 0.0642 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0119 | 0.0909 | 0.1152 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0119 | 0.0909 | 0.1152 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0386 | 0.4264 | 0.4994 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0218 | 0.2151 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0 | 0.5 |
Leishmania major | phosphonopyruvate decarboxylase-like protein | 0.0218 | 0.2151 | 0.5044 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0386 | 0.4264 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0386 | 0.4264 | 0.4994 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0675 | 0.7894 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0386 | 0.4264 | 0.4994 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0107 | 0.0758 | 0.0961 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0098 | 0.0642 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0218 | 0.2151 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0098 | 0.0642 | 0.5 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0218 | 0.2151 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0107 | 0.0758 | 0.0961 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0675 | 0.7894 | 1 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0098 | 0.0642 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0386 | 0.4264 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0107 | 0.0758 | 0.0961 |
Schistosoma mansoni | acetolactate synthase | 0.0576 | 0.666 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0675 | 0.7894 | 1 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0289 | 0.3038 | 0.3848 |
Loa Loa (eye worm) | ILVBL protein | 0.0408 | 0.4547 | 1 |
Treponema pallidum | pyruvate oxidoreductase | 0.0098 | 0.0642 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0107 | 0.0758 | 0.0961 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0675 | 0.7894 | 1 |
Echinococcus multilocularis | geminin | 0.0174 | 0.1596 | 0.1614 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1596 | 0.056 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SH | 0.012 | 0.0916 | 0.0222 |
Mycobacterium ulcerans | hypothetical protein | 0.0675 | 0.7894 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0098 | 0.0642 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0386 | 0.4264 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0576 | 0.666 | 1 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0675 | 0.7894 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase (beta subunit) | 0.0098 | 0.0642 | 0.0814 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.012 | 0.0916 | 0.0378 |
Mycobacterium ulcerans | hypothetical protein | 0.0218 | 0.2151 | 0.208 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.9892 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0119 | 0.0909 | 0.1152 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0098 | 0.0642 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0675 | 0.7894 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0107 | 0.0758 | 0.0961 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0098 | 0.0642 | 0.5 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0387 | 0.4272 | 0.9397 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0119 | 0.0909 | 0.0211 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0107 | 0.0758 | 0.0961 |
Brugia malayi | Serotonin receptor | 0.0564 | 0.6505 | 0.8241 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0218 | 0.2151 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0675 | 0.7894 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 574 nM | Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay | ChEMBL. | 21146986 |
EC50 (functional) | = 1158 nM | Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay | ChEMBL. | 21146986 |
EC50 (functional) | = 1227 nM | Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay | ChEMBL. | 21146986 |
Emax (functional) | = 27 % | Agonist activity at human recombinant 5HT2A receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay relative to 5-HT | ChEMBL. | 21146986 |
Emax (functional) | = 79 % | Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay relative to 5-HT | ChEMBL. | 21146986 |
Emax (functional) | = 102 % | Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay relative to 5-HT | ChEMBL. | 21146986 |
Inhibition (binding) | Inhibition of human ERG expressed in CHO cells at 10 uM by whole cell patch-clamp technique | ChEMBL. | 21146986 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.