Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.007 | 0.1769 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0125 | 0.4798 | 0.4798 |
Echinococcus granulosus | geminin | 0.0167 | 0.7167 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 0.7167 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.3729 | 0.3454 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.4387 | 0.414 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0218 | 1 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.007 | 0.1769 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.3729 | 0.3454 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0125 | 0.481 | 0.9179 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.007 | 0.1769 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.3729 | 0.3454 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.3729 | 0.3454 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0218 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.4387 | 0.4387 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0093 | 0.3041 | 0.2735 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0218 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.7167 | 0.5068 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0218 | 1 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0125 | 0.4798 | 0.4798 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.007 | 0.1769 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.3729 | 0.3729 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.3729 | 0.3454 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0421 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.4387 | 0.414 |
Mycobacterium ulcerans | hypothetical protein | 0.0218 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.7167 | 0.5068 |
Mycobacterium ulcerans | acetolactate synthase | 0.0125 | 0.4798 | 0.4798 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.3729 | 0.3454 |
Schistosoma mansoni | acetolactate synthase | 0.0186 | 0.8231 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0125 | 0.4798 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0125 | 0.4798 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.4387 | 0.414 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0218 | 1 | 1 |
Leishmania major | phosphonopyruvate decarboxylase-like protein | 0.007 | 0.1769 | 0.308 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0218 | 1 | 1 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0125 | 0.4798 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.007 | 0.1769 | 0.1769 |
Loa Loa (eye worm) | ILVBL protein | 0.0132 | 0.5202 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0186 | 0.8231 | 1 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21145139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.