Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin D2 receptor (DP) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | rhodopsin orphan GPCR | prostaglandin D2 receptor (DP) | 359 aa | 312 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | acyl-CoA synthetase | 0.0195 | 0.4798 | 0.5 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0195 | 0.4798 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0341 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0195 | 0.4798 | 0.4798 |
Echinococcus granulosus | geminin | 0.0164 | 0.3697 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0291 | 0.8231 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0206 | 0.5202 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.011 | 0.1769 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0291 | 0.8231 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0195 | 0.4798 | 0.4798 |
Mycobacterium ulcerans | hypothetical protein | 0.011 | 0.1769 | 0.1769 |
Mycobacterium ulcerans | hypothetical protein | 0.0341 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0341 | 1 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0341 | 1 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.011 | 0.1769 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase | 0.0195 | 0.4798 | 0.4798 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.011 | 0.1769 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.011 | 0.1769 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0341 | 1 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0341 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0341 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 0.3697 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0195 | 0.4798 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7.19 | Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scintillation proximity assay | ChEMBL. | 21147533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.