Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin D2 receptor (DP) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | rhodopsin orphan GPCR | prostaglandin D2 receptor (DP) | 359 aa | 312 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0145 | 0.1769 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase | 0.0257 | 0.4798 | 0.4798 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0449 | 1 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0449 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0166 | 0.2324 | 0.5 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0449 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0257 | 0.4798 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0449 | 1 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0145 | 0.1769 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0145 | 0.1769 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0449 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0257 | 0.4798 | 0.4798 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0449 | 1 | 1 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0257 | 0.4798 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0257 | 0.4798 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0449 | 1 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0257 | 0.4798 | 0.4798 |
Mycobacterium ulcerans | hypothetical protein | 0.0145 | 0.1769 | 0.1769 |
Schistosoma mansoni | acetolactate synthase | 0.0384 | 0.8231 | 1 |
Echinococcus granulosus | geminin | 0.0166 | 0.2324 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0384 | 0.8231 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0145 | 0.1769 | 0.5 |
Loa Loa (eye worm) | ILVBL protein | 0.0272 | 0.5202 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8.3 | Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scintillation proximity assay | ChEMBL. | 21147533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.