Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | transient receptor potential cation channel, subfamily C, member 4 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | short transient receptor potential channel 6 | transient receptor potential cation channel, subfamily C, member 4 | 890 aa | 799 aa | 31.2 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0113 | 0.9469 | 0.9469 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4469 | 0.343 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2256 | 0.2256 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4469 | 0.343 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.4079 | 0.4079 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1582 | 0.1582 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1582 | 0.3539 |
Schistosoma mansoni | transient receptor potential channel | 0.0078 | 0.4609 | 0.3596 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4469 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2256 | 0.5047 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0078 | 0.4609 | 0.4609 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4469 | 0.4469 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4469 | 0.4469 |
Schistosoma mansoni | cytochrome b | 0.0073 | 0.3972 | 0.284 |
Toxoplasma gondii | apocytochrome b, putative | 0.0073 | 0.3972 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0073 | 0.3972 | 0.284 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2256 | 0.2256 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4469 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0073 | 0.3972 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4469 | 0.343 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4469 | 0.343 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4469 | 0.4469 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1582 | 0.1582 |
Plasmodium vivax | cytochrome b | 0.0073 | 0.3972 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4469 | 0.4469 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2256 | 0.5047 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0078 | 0.4609 | 0.4609 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4469 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0078 | 0.4609 | 0.4609 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1582 | 0.1582 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0117 | 1 | 1 |
Loa Loa (eye worm) | cytochrome b | 0.0073 | 0.3972 | 0.3972 |
Brugia malayi | cytochrome b | 0.0073 | 0.3972 | 0.8887 |
Toxoplasma gondii | cytochrome b | 0.0073 | 0.3972 | 0.5 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0113 | 0.9469 | 0.9469 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4469 | 0.4469 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0078 | 0.4609 | 0.4609 |
Schistosoma mansoni | transient receptor potential channel | 0.0078 | 0.4609 | 0.3596 |
Echinococcus granulosus | cytochrome B | 0.0073 | 0.3972 | 0.3972 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4469 | 0.343 |
Schistosoma mansoni | transient receptor potential channel | 0.0117 | 1 | 1 |
Plasmodium falciparum | cytochrome b | 0.0073 | 0.3972 | 0.5 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0117 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1582 | 0.1582 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0.944 uM | PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that activate transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2237, AID2259] | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 21.1923 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.