Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.44 | 1 |
Echinococcus granulosus | cytochrome B | 0.0069 | 0.3005 | 0.6326 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.44 | 0.404 |
Loa Loa (eye worm) | cytochrome b | 0.0069 | 0.3005 | 0.3005 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.1285 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.44 | 1 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.44 | 1 |
Plasmodium falciparum | cytochrome b | 0.0069 | 0.3005 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.44 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0604 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0604 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0951 | 0.0951 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.44 | 1 |
Plasmodium vivax | cytochrome b | 0.0069 | 0.3005 | 0.5 |
Brugia malayi | cytochrome b | 0.0069 | 0.3005 | 0.2556 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.44 | 1 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.44 | 1 |
Toxoplasma gondii | cytochrome b | 0.0069 | 0.3005 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.44 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.1285 | 0.0969 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0951 | 0.7399 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.44 | 0.44 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0069 | 0.3005 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0069 | 0.3005 | 0.6326 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.1285 | 0.0969 |
Toxoplasma gondii | apocytochrome b, putative | 0.0069 | 0.3005 | 0.5 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.0951 | 0.0369 |
Schistosoma mansoni | cytochrome b | 0.0069 | 0.3005 | 0.6326 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0604 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0604 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.