Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | ubiquinol-cytochrome C reductase QcrB | 0.1815 | 1 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.0202 | 1 |
Schistosoma mansoni | cytochrome b | 0.0312 | 0.1506 | 0.5452 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0511 | 0.263 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0511 | 0.263 | 1 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.0202 | 0.0176 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.0202 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.0202 | 0.0176 |
Brugia malayi | Fli-1 protein | 0.0224 | 0.1006 | 0.6682 |
Toxoplasma gondii | cytochrome b | 0.0511 | 0.263 | 1 |
Loa Loa (eye worm) | fli-1 protein | 0.0224 | 0.1006 | 0.6682 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.0202 | 0.0176 |
Brugia malayi | Heterochromatin protein 1 | 0.0081 | 0.0202 | 0.1342 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.0202 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0074 | 0.0159 | 0.1053 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.002 | 0.0969 |
Brugia malayi | Ets-domain containing protein | 0.0074 | 0.0159 | 0.1053 |
Plasmodium falciparum | cytochrome b | 0.0511 | 0.263 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.0202 | 0.0176 |
Brugia malayi | cytochrome b | 0.0312 | 0.1506 | 1 |
Schistosoma mansoni | ets-related | 0.0224 | 0.1006 | 0.343 |
Onchocerca volvulus | 0.1815 | 1 | 1 | |
Mycobacterium tuberculosis | Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) | 0.1815 | 1 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0049 | 0.002 | 0.002 |
Plasmodium vivax | cytochrome b | 0.0511 | 0.263 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.0202 | 1 |
Loa Loa (eye worm) | cytochrome b | 0.0312 | 0.1506 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0081 | 0.0202 | 0.1342 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.002 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0098 | 0.0652 |
Echinococcus granulosus | cytochrome B | 0.0511 | 0.263 | 1 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0074 | 0.0159 | 0.1053 |
Toxoplasma gondii | apocytochrome b, putative | 0.0511 | 0.263 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxis | ChEMBL. | 21341682 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.