Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | ubiquinol-cytochrome C reductase QcrB | 0.1211 | 1 | 0.5 |
Brugia malayi | cytochrome b | 0.0208 | 0.1475 | 0.8 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.1841 | 1 |
Toxoplasma gondii | apocytochrome b, putative | 0.0133 | 0.0833 | 0.317 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0341 | 0.2603 | 0.5 |
Mycobacterium tuberculosis | Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) | 0.1211 | 1 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0011 | 0.0043 |
Plasmodium vivax | cytochrome b | 0.0341 | 0.2603 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.8028 | 1 |
Plasmodium falciparum | cytochrome b | 0.0341 | 0.2603 | 0.5 |
Onchocerca volvulus | 0.0286 | 0.2136 | 0.2127 | |
Onchocerca volvulus | 0.1211 | 1 | 1 | |
Schistosoma mansoni | cytochrome b | 0.0208 | 0.1475 | 0.5648 |
Toxoplasma gondii | cytochrome b | 0.0341 | 0.2603 | 1 |
Toxoplasma gondii | apocytochrome b, putative | 0.0341 | 0.2603 | 1 |
Echinococcus granulosus | cytochrome B | 0.0341 | 0.2603 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.2136 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.1841 | 1 |
Schistosoma mansoni | cytochrome b | 0.0341 | 0.2603 | 1 |
Loa Loa (eye worm) | cytochrome b | 0.0208 | 0.1475 | 0.8 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.2908 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 0.3294 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 67.4555 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.