Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | ubiquinol-cytochrome C reductase QcrB | 0.1773 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0003 | 0.0019 |
Toxoplasma gondii | apocytochrome b, putative | 0.0499 | 0.2574 | 1 |
Mycobacterium tuberculosis | Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) | 0.1773 | 1 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0393 | 0.1954 | 0.5 |
Plasmodium falciparum | cytochrome b | 0.0499 | 0.2574 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0499 | 0.2574 | 1 |
Onchocerca volvulus | 0.1773 | 1 | 1 | |
Loa Loa (eye worm) | cytochrome b | 0.0305 | 0.1442 | 1 |
Echinococcus granulosus | cytochrome B | 0.0499 | 0.2574 | 1 |
Toxoplasma gondii | cytochrome b | 0.0499 | 0.2574 | 1 |
Plasmodium vivax | cytochrome b | 0.0499 | 0.2574 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0305 | 0.1442 | 0.5601 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0499 | 0.2574 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0003 | 0.0019 |
Brugia malayi | cytochrome b | 0.0305 | 0.1442 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD99 (functional) | = 0.5 ug ml-1 | Bactericidal activity against Escherichia coli K-12 DM4100 after 2 hrs in presence of protein synthesis inhibitor chloramphenicol treated 10 mins before compound challenge | ChEMBL. | 20855738 |
MIC (functional) | = 0.25 ug ml-1 | Bacteriostatic activity against Escherichia coli K-12 DM4100 | ChEMBL. | 20855738 |
Ratio (functional) | = 2 | Ratio of LD99 for Escherichia coli K-12 DM4100 to MIC for Escherichia coli K-12 DM4100 | ChEMBL. | 20855738 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.