Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | pyruvate dehydrogenase subunit beta | 0.0078 | 1 | 1 |
Chlamydia trachomatis | oxoisovalerate dehydrogenase subunits alpha/beta | 0.0061 | 0.6787 | 0.6787 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) | 0.0055 | 0.5529 | 0.5 |
Trypanosoma cruzi | transketolase, putative | 0.0055 | 0.5529 | 0.5529 |
Leishmania major | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0055 | 0.5529 | 0.5529 |
Plasmodium falciparum | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0055 | 0.5529 | 0.5529 |
Entamoeba histolytica | transketolase, putative | 0.0055 | 0.5529 | 0.5 |
Entamoeba histolytica | transketolase, putative | 0.0055 | 0.5529 | 0.5 |
Trypanosoma brucei | transketolase, putative | 0.0055 | 0.5529 | 0.5529 |
Toxoplasma gondii | transketolase | 0.0055 | 0.5529 | 0.5529 |
Plasmodium vivax | pyruvate dehydrogenase E1 component subunit beta, putative | 0.0078 | 1 | 1 |
Mycobacterium tuberculosis | Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB | 0.0055 | 0.5529 | 0.5 |
Schistosoma mansoni | pyruvate dehydrogenase (lipoamide) | 0.0078 | 1 | 1 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0055 | 0.5529 | 0.5529 |
Entamoeba histolytica | transketolase, putative | 0.0055 | 0.5529 | 0.5 |
Plasmodium falciparum | pyruvate dehydrogenase E1 component subunit beta | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Schistosoma mansoni | transketolase | 0.0055 | 0.5529 | 0.5529 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5529 | 0.5529 |
Wolbachia endosymbiont of Brugia malayi | transketolase | 0.0055 | 0.5529 | 0.5529 |
Loa Loa (eye worm) | 2-oxoisovalerate dehydrogenase subunit beta | 0.0055 | 0.5529 | 0.5529 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0055 | 0.5529 | 0.5529 |
Chlamydia trachomatis | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0055 | 0.5529 | 0.5529 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0055 | 0.5529 | 0.5529 |
Brugia malayi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor | 0.0055 | 0.5529 | 0.5529 |
Entamoeba histolytica | transketolase, chloroplast, putative | 0.0055 | 0.5529 | 0.5 |
Trichomonas vaginalis | transketolase, putative | 0.0055 | 0.5529 | 0.5 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate synthase, putative | 0.0055 | 0.5529 | 0.5529 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate synthase | 0.0055 | 0.5529 | 0.5529 |
Toxoplasma gondii | pyruvate dehydrogenase E1 component, beta subunit, putative | 0.0055 | 0.5529 | 0.5529 |
Onchocerca volvulus | 0.0059 | 0.6443 | 0.5 | |
Echinococcus granulosus | transketolase | 0.0055 | 0.5529 | 0.5529 |
Trypanosoma brucei | pyruvate dehydrogenase E1 beta subunit, putative | 0.0078 | 1 | 1 |
Echinococcus multilocularis | transketolase | 0.0055 | 0.5529 | 0.5529 |
Echinococcus multilocularis | pyruvate dehydrogenase | 0.0078 | 1 | 1 |
Leishmania major | transketolase | 0.0055 | 0.5529 | 0.5529 |
Schistosoma mansoni | transketolase | 0.0055 | 0.5529 | 0.5529 |
Trypanosoma cruzi | transketolase, putative | 0.0055 | 0.5529 | 0.5529 |
Leishmania major | pyruvate dehydrogenase E1 beta subunit, putative | 0.0078 | 1 | 1 |
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0055 | 0.5529 | 1 |
Treponema pallidum | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0055 | 0.5529 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PD-HE1Beta | 0.0078 | 1 | 1 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0055 | 0.5529 | 1 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0078 | 1 | 1 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0055 | 0.5529 | 0.5529 |
Brugia malayi | transketolase | 0.0055 | 0.5529 | 0.5529 |
Wolbachia endosymbiont of Brugia malayi | pyruvate dehydrogenase subunit beta | 0.0078 | 1 | 1 |
Echinococcus multilocularis | transketolase | 0.0055 | 0.5529 | 0.5529 |
Mycobacterium ulcerans | pyruvate dehydrogenase E1 component subunit PdhB | 0.0055 | 0.5529 | 1 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0055 | 0.5529 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Echinococcus granulosus | transketolase | 0.0055 | 0.5529 | 0.5529 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) | 0.0055 | 0.5529 | 1 |
Plasmodium vivax | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0055 | 0.5529 | 0.5529 |
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, putative | 0.0078 | 1 | 1 |
Chlamydia trachomatis | transketolase | 0.0055 | 0.5529 | 0.5529 |
Mycobacterium ulcerans | transketolase | 0.0055 | 0.5529 | 1 |
Echinococcus granulosus | pyruvate dehydrogenase | 0.0078 | 1 | 1 |
Toxoplasma gondii | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0055 | 0.5529 | 0.5529 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0055 | 0.5529 | 0.5529 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0078 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.