Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | pyruvate dehydrogenase E1 component subunit beta | 0.0048 | 1 | 1 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0036 | 0.6302 | 0.6302 |
Plasmodium vivax | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0036 | 0.6302 | 0.6302 |
Chlamydia trachomatis | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0036 | 0.6302 | 0.6302 |
Echinococcus granulosus | pyruvate dehydrogenase | 0.0048 | 1 | 1 |
Leishmania major | transketolase | 0.0036 | 0.6302 | 0.6302 |
Entamoeba histolytica | transketolase, putative | 0.0036 | 0.6302 | 0.5 |
Brugia malayi | transketolase | 0.0036 | 0.6302 | 0.6302 |
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, putative | 0.0048 | 1 | 1 |
Echinococcus granulosus | transketolase | 0.0036 | 0.6302 | 0.6302 |
Plasmodium vivax | pyruvate dehydrogenase E1 component subunit beta, putative | 0.0048 | 1 | 1 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0036 | 0.6302 | 0.6302 |
Mycobacterium ulcerans | pyruvate dehydrogenase E1 component subunit PdhB | 0.0036 | 0.6302 | 1 |
Chlamydia trachomatis | pyruvate dehydrogenase subunit beta | 0.0048 | 1 | 1 |
Mycobacterium ulcerans | transketolase | 0.0036 | 0.6302 | 1 |
Loa Loa (eye worm) | 2-oxoisovalerate dehydrogenase subunit beta | 0.0036 | 0.6302 | 0.6302 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0048 | 1 | 1 |
Schistosoma mansoni | transketolase | 0.0036 | 0.6302 | 0.6302 |
Mycobacterium tuberculosis | Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB | 0.0036 | 0.6302 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | pyruvate dehydrogenase subunit beta | 0.0048 | 1 | 1 |
Brugia malayi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor | 0.0036 | 0.6302 | 0.6302 |
Toxoplasma gondii | transketolase | 0.0036 | 0.6302 | 0.6302 |
Chlamydia trachomatis | transketolase | 0.0036 | 0.6302 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Treponema pallidum | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0036 | 0.6302 | 0.5 |
Schistosoma mansoni | pyruvate dehydrogenase (lipoamide) | 0.0048 | 1 | 1 |
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0036 | 0.6302 | 1 |
Schistosoma mansoni | transketolase | 0.0036 | 0.6302 | 0.6302 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate synthase | 0.0036 | 0.6302 | 0.6302 |
Trichomonas vaginalis | transketolase, putative | 0.0036 | 0.6302 | 0.5 |
Echinococcus multilocularis | transketolase | 0.0036 | 0.6302 | 0.6302 |
Trypanosoma brucei | transketolase, putative | 0.0036 | 0.6302 | 0.6302 |
Chlamydia trachomatis | oxoisovalerate dehydrogenase subunits alpha/beta | 0.0041 | 0.7735 | 0.7735 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PD-HE1Beta | 0.0048 | 1 | 1 |
Plasmodium falciparum | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0036 | 0.6302 | 0.6302 |
Leishmania major | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0036 | 0.6302 | 0.6302 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0048 | 1 | 1 |
Echinococcus multilocularis | pyruvate dehydrogenase | 0.0048 | 1 | 1 |
Entamoeba histolytica | transketolase, chloroplast, putative | 0.0036 | 0.6302 | 0.5 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate synthase, putative | 0.0036 | 0.6302 | 0.6302 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) | 0.0036 | 0.6302 | 0.5 |
Leishmania major | pyruvate dehydrogenase E1 beta subunit, putative | 0.0048 | 1 | 1 |
Toxoplasma gondii | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0036 | 0.6302 | 0.6302 |
Echinococcus granulosus | transketolase | 0.0036 | 0.6302 | 0.6302 |
Trypanosoma cruzi | transketolase, putative | 0.0036 | 0.6302 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.6302 | 0.6302 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0036 | 0.6302 | 0.6302 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0036 | 0.6302 | 0.5 |
Trypanosoma cruzi | transketolase, putative | 0.0036 | 0.6302 | 0.6302 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0036 | 0.6302 | 1 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0036 | 0.6302 | 0.6302 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0036 | 0.6302 | 0.6302 |
Entamoeba histolytica | transketolase, putative | 0.0036 | 0.6302 | 0.5 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) | 0.0036 | 0.6302 | 1 |
Trypanosoma brucei | pyruvate dehydrogenase E1 beta subunit, putative | 0.0048 | 1 | 1 |
Echinococcus multilocularis | transketolase | 0.0036 | 0.6302 | 0.6302 |
Entamoeba histolytica | transketolase, putative | 0.0036 | 0.6302 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | transketolase | 0.0036 | 0.6302 | 0.6302 |
Onchocerca volvulus | 0.0035 | 0.5945 | 0.5 | |
Toxoplasma gondii | pyruvate dehydrogenase E1 component, beta subunit, putative | 0.0036 | 0.6302 | 0.6302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.