Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate dehydrogenase (lipoamide) | 0.0078 | 1 | 1 |
Onchocerca volvulus | 0.0059 | 0.4544 | 0.5 | |
Echinococcus multilocularis | transketolase | 0.0054 | 0.3152 | 0.3152 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0054 | 0.3152 | 0.5 |
Brugia malayi | transketolase | 0.0054 | 0.3152 | 0.3152 |
Entamoeba histolytica | transketolase, putative | 0.0054 | 0.3152 | 1 |
Entamoeba histolytica | transketolase, chloroplast, putative | 0.0054 | 0.3152 | 1 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) | 0.0054 | 0.3152 | 0.5 |
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0054 | 0.3152 | 0.5 |
Mycobacterium ulcerans | transketolase | 0.0054 | 0.3152 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Plasmodium vivax | pyruvate dehydrogenase E1 component subunit beta, putative | 0.0078 | 1 | 1 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0078 | 1 | 1 |
Trichomonas vaginalis | transketolase, putative | 0.0054 | 0.3152 | 0.5 |
Schistosoma mansoni | transketolase | 0.0054 | 0.3152 | 0.3152 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0078 | 1 | 1 |
Echinococcus multilocularis | transketolase | 0.0054 | 0.3152 | 0.3152 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) | 0.0054 | 0.3152 | 0.5 |
Chlamydia trachomatis | oxoisovalerate dehydrogenase subunits alpha/beta | 0.0061 | 0.5081 | 0.2816 |
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, putative | 0.0078 | 1 | 1 |
Echinococcus granulosus | pyruvate dehydrogenase | 0.0078 | 1 | 1 |
Plasmodium falciparum | pyruvate dehydrogenase E1 component subunit beta | 0.0078 | 1 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0054 | 0.3152 | 1 |
Mycobacterium ulcerans | pyruvate dehydrogenase E1 component subunit PdhB | 0.0054 | 0.3152 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Treponema pallidum | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0054 | 0.3152 | 0.5 |
Leishmania major | pyruvate dehydrogenase E1 beta subunit, putative | 0.0078 | 1 | 1 |
Mycobacterium tuberculosis | Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB | 0.0054 | 0.3152 | 0.5 |
Chlamydia trachomatis | pyruvate dehydrogenase subunit beta | 0.0078 | 1 | 1 |
Schistosoma mansoni | transketolase | 0.0054 | 0.3152 | 0.3152 |
Echinococcus granulosus | transketolase | 0.0054 | 0.3152 | 0.3152 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PD-HE1Beta | 0.0078 | 1 | 1 |
Brugia malayi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor | 0.0054 | 0.3152 | 0.3152 |
Wolbachia endosymbiont of Brugia malayi | pyruvate dehydrogenase subunit beta | 0.0078 | 1 | 1 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0054 | 0.3152 | 0.5 |
Trypanosoma brucei | pyruvate dehydrogenase E1 beta subunit, putative | 0.0078 | 1 | 1 |
Echinococcus granulosus | transketolase | 0.0054 | 0.3152 | 0.3152 |
Entamoeba histolytica | transketolase, putative | 0.0054 | 0.3152 | 1 |
Echinococcus multilocularis | pyruvate dehydrogenase | 0.0078 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.581 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.