Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Echinococcus multilocularis | transketolase | 0.0035 | 0.6302 | 0.6302 |
Wolbachia endosymbiont of Brugia malayi | transketolase | 0.0035 | 0.6302 | 0.6302 |
Onchocerca volvulus | 0.0034 | 0.5945 | 0.5 | |
Toxoplasma gondii | pyruvate dehydrogenase E1 component, beta subunit, putative | 0.0035 | 0.6302 | 0.6302 |
Entamoeba histolytica | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) | 0.0035 | 0.6302 | 1 |
Trypanosoma brucei | pyruvate dehydrogenase E1 beta subunit, putative | 0.0046 | 1 | 1 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 1 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0035 | 0.6302 | 0.5 |
Trypanosoma cruzi | transketolase, putative | 0.0035 | 0.6302 | 0.6302 |
Leishmania major | pyruvate dehydrogenase E1 beta subunit, putative | 0.0046 | 1 | 1 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) | 0.0035 | 0.6302 | 0.5 |
Toxoplasma gondii | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 0.6302 |
Echinococcus granulosus | transketolase | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma cruzi | transketolase, putative | 0.0035 | 0.6302 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0046 | 1 | 1 |
Entamoeba histolytica | transketolase, chloroplast, putative | 0.0035 | 0.6302 | 0.5 |
Echinococcus multilocularis | pyruvate dehydrogenase | 0.0046 | 1 | 1 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate synthase, putative | 0.0035 | 0.6302 | 0.6302 |
Chlamydia trachomatis | oxoisovalerate dehydrogenase subunits alpha/beta | 0.0039 | 0.7735 | 0.7735 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PD-HE1Beta | 0.0046 | 1 | 1 |
Plasmodium falciparum | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0035 | 0.6302 | 0.6302 |
Leishmania major | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate synthase | 0.0035 | 0.6302 | 0.6302 |
Echinococcus multilocularis | transketolase | 0.0035 | 0.6302 | 0.6302 |
Trichomonas vaginalis | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Trypanosoma brucei | transketolase, putative | 0.0035 | 0.6302 | 0.6302 |
Brugia malayi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor | 0.0035 | 0.6302 | 0.6302 |
Toxoplasma gondii | transketolase | 0.0035 | 0.6302 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Chlamydia trachomatis | transketolase | 0.0035 | 0.6302 | 0.6302 |
Treponema pallidum | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 0.5 |
Schistosoma mansoni | transketolase | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0035 | 0.6302 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase (lipoamide) | 0.0046 | 1 | 1 |
Mycobacterium tuberculosis | Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB | 0.0035 | 0.6302 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | pyruvate dehydrogenase subunit beta | 0.0046 | 1 | 1 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium ulcerans | pyruvate dehydrogenase E1 component subunit PdhB | 0.0035 | 0.6302 | 1 |
Chlamydia trachomatis | pyruvate dehydrogenase subunit beta | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | 2-oxoisovalerate dehydrogenase subunit beta | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium ulcerans | transketolase | 0.0035 | 0.6302 | 1 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0046 | 1 | 1 |
Schistosoma mansoni | transketolase | 0.0035 | 0.6302 | 0.6302 |
Echinococcus granulosus | transketolase | 0.0035 | 0.6302 | 0.6302 |
Plasmodium vivax | pyruvate dehydrogenase E1 component subunit beta, putative | 0.0046 | 1 | 1 |
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, putative | 0.0046 | 1 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Brugia malayi | transketolase | 0.0035 | 0.6302 | 0.6302 |
Plasmodium vivax | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Chlamydia trachomatis | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 0.6302 |
Echinococcus granulosus | pyruvate dehydrogenase | 0.0046 | 1 | 1 |
Leishmania major | transketolase | 0.0035 | 0.6302 | 0.6302 |
Plasmodium falciparum | pyruvate dehydrogenase E1 component subunit beta | 0.0046 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.