Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0323 | 0.0849 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1386 | 0.3642 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0095 | 0.025 |
Echinococcus granulosus | cytochrome B | 0.0379 | 0.3805 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0095 | 0.025 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0095 | 0.025 |
Toxoplasma gondii | cytochrome b | 0.0379 | 0.3805 | 0.5 |
Plasmodium falciparum | cytochrome b | 0.0379 | 0.3805 | 0.5 |
Toxoplasma gondii | apocytochrome b, putative | 0.0379 | 0.3805 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0095 | 0.025 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0095 | 0.025 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0379 | 0.3805 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1386 | 0.3642 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.052 | 0.1366 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0095 | 0.025 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | cytochrome b | 0.0379 | 0.3805 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0095 | 0.025 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0095 | 0.025 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.052 | 0.1366 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.052 | 0.1366 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0323 | 0.0849 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0095 | 0.025 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0095 | 0.025 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0095 | 0.025 |
Schistosoma mansoni | cytochrome b | 0.0379 | 0.3805 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.052 | 0.1366 |
Plasmodium vivax | cytochrome b | 0.0379 | 0.3805 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1386 | 0.3642 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0095 | 0.0095 |
Brugia malayi | cytochrome b | 0.0379 | 0.3805 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0323 | 0.0849 |
Schistosoma mansoni | cytochrome b | 0.0379 | 0.3805 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.4668 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3489 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.