Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | Gln-2 protein | 0.0237 | 0.4362 | 0.4362 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0299 | 0.5676 | 0.5041 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0392 | 0.7667 | 1 |
Wolbachia endosymbiont of Brugia malayi | glutamine synthetase | 0.0093 | 0.1282 | 0.5 |
Treponema pallidum | 1-pyrroline-5-carboxylate reductase (proC) | 0.0033 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) | 0.0237 | 0.4362 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0299 | 0.5676 | 0.5676 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0501 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0299 | 0.5676 | 0.5041 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0501 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0299 | 0.5676 | 0.7403 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.0392 | 0.7667 | 0.7667 |
Echinococcus multilocularis | carbonic anhydrase | 0.0299 | 0.5676 | 0.5676 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0501 | 1 | 1 |
Plasmodium vivax | glutamine synthetase, putative | 0.0237 | 0.4362 | 0.569 |
Echinococcus multilocularis | glutamine synthetase | 0.0369 | 0.7175 | 0.7175 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 0.0237 | 0.4362 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0501 | 1 | 1 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.0392 | 0.7667 | 0.7667 |
Trichomonas vaginalis | glutamine synthetase, putative | 0.0093 | 0.1282 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0501 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0299 | 0.5676 | 0.7403 |
Trypanosoma brucei | glutamine synthetase, putative | 0.0369 | 0.7175 | 0.7175 |
Leishmania major | glutamine synthetase, putative | 0.0369 | 0.7175 | 0.7175 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0299 | 0.5676 | 0.5676 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0299 | 0.5676 | 0.5676 |
Onchocerca volvulus | Glutamine synthetase homolog | 0.0237 | 0.4362 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0299 | 0.5676 | 0.5676 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.0392 | 0.7667 | 0.7667 |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.0392 | 0.7667 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0299 | 0.5676 | 0.5676 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 0.5676 | 0.5041 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0299 | 0.5676 | 0.5676 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.5676 | 0.5676 |
Entamoeba histolytica | glutamine synthetase, putative | 0.0093 | 0.1282 | 0.5 |
Trichomonas vaginalis | glutamine synthetase-bacteria, putative | 0.0093 | 0.1282 | 1 |
Toxoplasma gondii | glutamine synthetase, type I, putative | 0.0237 | 0.4362 | 0.569 |
Mycobacterium ulcerans | glutamine synthetase | 0.0237 | 0.4362 | 1 |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.0392 | 0.7667 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.5676 | 0.5676 |
Echinococcus multilocularis | carbonic anhydrase | 0.0299 | 0.5676 | 0.5676 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0392 | 0.7667 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0501 | 1 | 1 |
Schistosoma mansoni | glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) | 0.0369 | 0.7175 | 0.676 |
Mycobacterium ulcerans | hypothetical protein | 0.0093 | 0.1282 | 0.2938 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0369 | 0.7175 | 0.7175 |
Echinococcus granulosus | carbonic anhydrase | 0.0299 | 0.5676 | 0.5676 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0501 | 1 | 1 |
Plasmodium falciparum | glutamine synthetase, putative | 0.0237 | 0.4362 | 0.569 |
Entamoeba histolytica | glutamine synthetase, putative | 0.0093 | 0.1282 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 0.5676 | 0.5676 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0299 | 0.5676 | 0.5676 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0501 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0299 | 0.5676 | 0.5041 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0299 | 0.5676 | 0.5676 |
Leishmania major | carbonic anhydrase-like protein | 0.0501 | 1 | 1 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.0392 | 0.7667 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0501 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0501 | 1 | 1 |
Mycobacterium ulcerans | glutamine synthetase GlnA1 | 0.0237 | 0.4362 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0299 | 0.5676 | 0.5676 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0299 | 0.5676 | 0.5041 |
Leishmania major | vacuolar-type proton translocating pyrophosphatase 1, putative | 0.0392 | 0.7667 | 0.7667 |
Echinococcus granulosus | glutamine synthetase | 0.0369 | 0.7175 | 0.7175 |
Brugia malayi | glutamine synthetase | 0.0132 | 0.2105 | 0.2105 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) | 0.0093 | 0.1282 | 0.2938 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0369 | 0.7175 | 0.7175 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.0392 | 0.7667 | 0.7667 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.