Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0133 | 0.4759 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0232 | 1 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0133 | 0.4771 | 0.9234 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0133 | 0.4759 | 0.368 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.159 | 0.3077 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0075 | 0.1708 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.3841 | 0.3841 |
Schistosoma mansoni | acetolactate synthase | 0.0198 | 0.8218 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.014 | 0.5167 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0198 | 0.8218 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0075 | 0.1708 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.2589 | 0.3151 |
Mycobacterium ulcerans | acetolactate synthase | 0.0133 | 0.4759 | 0.368 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0232 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0232 | 1 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0337 | 0.0878 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0337 | 0.0878 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0232 | 1 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.3841 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0133 | 0.4759 | 0.368 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0075 | 0.1708 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0938 | 0.1815 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0232 | 1 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.3841 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0232 | 1 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0232 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0133 | 0.4759 | 0.5 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0075 | 0.1708 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0133 | 0.4759 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.