Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, putative | 0.0045 | 1 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Brugia malayi | transketolase | 0.0035 | 0.6302 | 0.6302 |
Leishmania major | transketolase | 0.0035 | 0.6302 | 0.6302 |
Echinococcus granulosus | pyruvate dehydrogenase | 0.0045 | 1 | 1 |
Chlamydia trachomatis | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 0.6302 |
Plasmodium vivax | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Plasmodium falciparum | pyruvate dehydrogenase E1 component subunit beta | 0.0045 | 1 | 1 |
Schistosoma mansoni | transketolase | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0035 | 0.6302 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase (lipoamide) | 0.0045 | 1 | 1 |
Treponema pallidum | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 0.5 |
Brugia malayi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor | 0.0035 | 0.6302 | 0.6302 |
Chlamydia trachomatis | transketolase | 0.0035 | 0.6302 | 0.6302 |
Toxoplasma gondii | transketolase | 0.0035 | 0.6302 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
Mycobacterium tuberculosis | Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB | 0.0035 | 0.6302 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | pyruvate dehydrogenase subunit beta | 0.0045 | 1 | 1 |
Schistosoma mansoni | transketolase | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0045 | 1 | 1 |
Mycobacterium ulcerans | transketolase | 0.0035 | 0.6302 | 1 |
Loa Loa (eye worm) | 2-oxoisovalerate dehydrogenase subunit beta | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium ulcerans | pyruvate dehydrogenase E1 component subunit PdhB | 0.0035 | 0.6302 | 1 |
Chlamydia trachomatis | pyruvate dehydrogenase subunit beta | 0.0045 | 1 | 1 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Plasmodium vivax | pyruvate dehydrogenase E1 component subunit beta, putative | 0.0045 | 1 | 1 |
Echinococcus granulosus | transketolase | 0.0035 | 0.6302 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 1 | 1 |
Trypanosoma cruzi | transketolase, putative | 0.0035 | 0.6302 | 0.6302 |
Toxoplasma gondii | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 0.6302 |
Echinococcus granulosus | transketolase | 0.0035 | 0.6302 | 0.6302 |
Leishmania major | pyruvate dehydrogenase E1 beta subunit, putative | 0.0045 | 1 | 1 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) | 0.0035 | 0.6302 | 0.5 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate synthase, putative | 0.0035 | 0.6302 | 0.6302 |
Entamoeba histolytica | transketolase, chloroplast, putative | 0.0035 | 0.6302 | 0.5 |
Echinococcus multilocularis | pyruvate dehydrogenase | 0.0045 | 1 | 1 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0045 | 1 | 1 |
Plasmodium falciparum | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0035 | 0.6302 | 0.6302 |
Leishmania major | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Chlamydia trachomatis | oxoisovalerate dehydrogenase subunits alpha/beta | 0.0039 | 0.7735 | 0.7735 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PD-HE1Beta | 0.0045 | 1 | 1 |
Trypanosoma brucei | transketolase, putative | 0.0035 | 0.6302 | 0.6302 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate synthase | 0.0035 | 0.6302 | 0.6302 |
Echinococcus multilocularis | transketolase | 0.0035 | 0.6302 | 0.6302 |
Trichomonas vaginalis | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase E1 component, beta subunit, putative | 0.0035 | 0.6302 | 0.6302 |
Onchocerca volvulus | 0.0034 | 0.5945 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | transketolase | 0.0035 | 0.6302 | 0.6302 |
Entamoeba histolytica | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Echinococcus multilocularis | transketolase | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma brucei | pyruvate dehydrogenase E1 beta subunit, putative | 0.0045 | 1 | 1 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) | 0.0035 | 0.6302 | 1 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0035 | 0.6302 | 0.6302 |
Entamoeba histolytica | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 1 |
Trypanosoma cruzi | transketolase, putative | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0035 | 0.6302 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.6302 | 0.6302 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.