Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | cytochrome b | 0.0128 | 0.2617 | 0.7049 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0903 | 0.2387 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0463 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0152 | 0.0401 |
Echinococcus multilocularis | peroxidasin | 0.0177 | 0.3712 | 0.3712 |
Schistosoma mansoni | cytochrome b | 0.0128 | 0.2617 | 0.7049 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0813 | 0.2147 |
Brugia malayi | RNA binding protein | 0.0066 | 0.1261 | 0.3332 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0555 | 0.1468 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0903 | 0.2387 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | cytochrome b | 0.0128 | 0.2617 | 0.6914 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | peroxidasin | 0.0177 | 0.3712 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Brugia malayi | Blistered cuticle protein 3 | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | peroxidasin | 0.0177 | 0.3712 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Brugia malayi | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.1261 | 0.3332 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0463 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0555 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | Peroxidasin | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0152 | 0.0152 |
Onchocerca volvulus | Peroxidasin homolog | 0.0177 | 0.3712 | 0.9809 |
Toxoplasma gondii | cytochrome b | 0.0128 | 0.2617 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0813 | 0.0813 |
Onchocerca volvulus | Peroxidasin homolog | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3784 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.1261 | 0.1261 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.1261 | 0.3332 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Plasmodium falciparum | cytochrome b | 0.0128 | 0.2617 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.1261 | 0.3332 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0813 | 0.2147 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0152 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0903 | 0.2387 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Toxoplasma gondii | apocytochrome b, putative | 0.0128 | 0.2617 | 1 |
Brugia malayi | cytochrome b | 0.0128 | 0.2617 | 0.6914 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0152 | 0.0152 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0813 | 0.0813 |
Onchocerca volvulus | Peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.1261 | 0.3332 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.1261 | 0.1261 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0152 | 0.0401 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Plasmodium vivax | cytochrome b | 0.0128 | 0.2617 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0463 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.1261 | 0.3332 |
Echinococcus granulosus | cytochrome B | 0.0128 | 0.2617 | 0.2617 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0152 | 0.0152 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | peroxidasin | 0.0177 | 0.3712 | 0.3712 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0813 | 0.0813 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0152 | 0.0401 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0903 | 0.2387 |
Brugia malayi | N-terminal motif family protein | 0.0181 | 0.3784 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0128 | 0.2617 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0181 | 0.3784 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0152 | 0.0152 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0813 | 0.0813 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0555 | 0.1468 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 794.2 nM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
IC50 (functional) | = 3132.5 nM | Antimalarial activity against chloroquine-,pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
IC50 (functional) | = 12371.4 nM | Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 21316974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.