TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 482.416 | Formula: C24H28BrN5O
H donors: 2 H acceptors: 2 LogP: 4.24 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)c1ccc(cc1Br)c1[nH]nc(c1)c1cccc(c1)C(=O)NC(C)C
InChi: 1S/C24H28BrN5O/c1-16(2)26-24(31)19-6-4-5-17(13-19)21-15-22(28-27-21)18-7-8-23(20(25)14-18)30-11-9-29(3)10-12-30/h4-8,13-16H,9-12H2,1-3H3,(H,26,31)(H,27,28)
InChiKey: FKCIPQLXSFDYKG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase D1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_130080	All targets in OG5_130080
Schistosoma japonicum	ko:K06070 protein kinase D, putative	Get druggable targets OG5_130080	All targets in OG5_130080
Loa Loa (eye worm)	CAMK/PKD protein kinase	Get druggable targets OG5_130080	All targets in OG5_130080
Loa Loa (eye worm)	CAMK/PKD protein kinase	Get druggable targets OG5_130080	All targets in OG5_130080
Onchocerca volvulus		Get druggable targets OG5_130080	All targets in OG5_130080
Schistosoma mansoni	protein kinase C mu	Get druggable targets OG5_130080	All targets in OG5_130080
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_130080	All targets in OG5_130080
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130080	All targets in OG5_130080
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130080	All targets in OG5_130080
Brugia malayi	Phorbol esters/diacylglycerol binding domain	Get druggable targets OG5_130080	All targets in OG5_130080
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130080	All targets in OG5_130080
Onchocerca volvulus		Get druggable targets OG5_130080	All targets in OG5_130080
Brugia malayi	C1-like domain containing protein	Get druggable targets OG5_130080	All targets in OG5_130080
Schistosoma japonicum	ko:K06070 protein kinase D, putative	Get druggable targets OG5_130080	All targets in OG5_130080
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130080	All targets in OG5_130080
Onchocerca volvulus		Get druggable targets OG5_130080	All targets in OG5_130080
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130080	All targets in OG5_130080

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	synaptotagmin, putative	0.0036	0.1246	0.4636
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0046	0.1869	0.1869
Echinococcus granulosus	neural cell expressed developmentally	0.0036	0.1246	0.1246
Echinococcus multilocularis	macrophage expressed protein	0.0127	0.744	0.744
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0057	0.2688	0.2688
Entamoeba histolytica	hypothetical protein	0.0036	0.1246	0.985
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.086	0.6801
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0036	0.1246	0.4636
Onchocerca volvulus	Multiple C2 domain and transmembrane region protein homolog	0.0036	0.1246	0.226
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Onchocerca volvulus		0.0031	0.086	0.1364
Echinococcus granulosus	calpain 5	0.0036	0.1246	0.1246
Plasmodium falciparum	perforin-like protein 3	0.0127	0.744	1
Onchocerca volvulus		0.0031	0.086	0.1364
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Plasmodium vivax	perforin-like protein 1	0.0127	0.744	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0022	0.0274	0.0274
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0036	0.1246	0.4636
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Echinococcus multilocularis	serine threonine protein kinase	0.0037	0.1265	0.1265
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Onchocerca volvulus		0.0031	0.086	0.1364
Echinococcus multilocularis	UNCoordinated family member (unc 13)	0.0036	0.1246	0.1246
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Schistosoma mansoni	hypothetical protein	0.0036	0.1246	0.1246
Schistosoma mansoni	cathepsin F (C01 family)	0.0031	0.086	0.086
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0036	0.1246	0.1246
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0083	0.4425	0.4425
Trichomonas vaginalis	synaptotagmin, putative	0.0036	0.1246	0.4636
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.086	0.3201
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Brugia malayi	NEDD4.2	0.0036	0.1246	0.1246
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0057	0.2688	1
Leishmania major	c2 domain protein, putative	0.0036	0.1246	0.211
Echinococcus multilocularis	copine 9	0.0036	0.1246	0.1246
Schistosoma mansoni	synaptotagmin	0.0036	0.1246	0.1246
Onchocerca volvulus		0.0074	0.3782	0.8157
Brugia malayi	Protein kinase c protein 2	0.0046	0.1888	0.1888
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.086	0.3201
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0031	0.086	0.1156
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0036	0.1246	0.1675
Echinococcus granulosus	extended synaptotagmin 2	0.0036	0.1246	0.1246
Echinococcus granulosus	intersectin 2	0.0036	0.1246	0.1246
Brugia malayi	Cathepsin L-like precursor	0.0031	0.086	0.086
Schistosoma mansoni	fer-1-related	0.0036	0.1246	0.1246
Onchocerca volvulus		0.0036	0.1246	0.226
Echinococcus granulosus	synaptotagmin 2	0.0036	0.1246	0.1246
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0036	0.1246	0.1246
Echinococcus multilocularis	cathepsin b	0.0165	1	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.4575	0.4422
Trichomonas vaginalis	copine, putative	0.0036	0.1246	0.4636
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.086	0.3201
Brugia malayi	protein kinase C II.	0.0046	0.1888	0.1888
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Trichomonas vaginalis	ion channel nompc, putative	0.0036	0.1246	0.4636
Onchocerca volvulus		0.0046	0.1869	0.371
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Echinococcus multilocularis	synaptotagmin	0.0036	0.1246	0.1246
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0031	0.086	0.0603
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Entamoeba histolytica	C2 domain containing protein	0.0036	0.1246	0.985
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Trichomonas vaginalis	synaptotagmin, putative	0.0036	0.1246	0.4636
Echinococcus granulosus	copine 9	0.0036	0.1246	0.1246
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0036	0.1246	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0274	0.1018
Echinococcus granulosus	synaptotagmin	0.0036	0.1246	0.1246
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.086	0.3201
Toxoplasma gondii	hypothetical protein	0.0036	0.1246	0.0586
Schistosoma mansoni	synaptotagmin	0.0036	0.1246	0.1246
Plasmodium falciparum	ferlin, putative	0.0036	0.1246	0.1675
Echinococcus multilocularis	myoferlin	0.0036	0.1246	0.1246
Trypanosoma brucei	C2 domain/Ankyrin repeats (3 copies), putative	0.0036	0.1246	0.4636
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Echinococcus granulosus	UNCoordinated family member unc 13	0.0036	0.1246	0.1246
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.086	0.3201
Schistosoma mansoni	mctp-related	0.0036	0.1246	0.1246
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Schistosoma mansoni	unc-13 (munc13)	0.0046	0.1869	0.1869
Entamoeba histolytica	hypothetical protein, conserved	0.0036	0.1246	0.985
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Onchocerca volvulus	Putative cc2d1b protein	0.0036	0.1246	0.226
Toxoplasma gondii	MAC/Perforin domain-containing protein	0.0127	0.744	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Plasmodium falciparum	perforin-like protein 5	0.0127	0.744	1
Trypanosoma cruzi	synaptotagmin, putative	0.0036	0.1246	0.1246
Echinococcus multilocularis	synaptotagmin 2	0.0036	0.1246	0.1246
Echinococcus granulosus	protein piccolo	0.0036	0.1246	0.1246
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0031	0.086	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.086	0.3201
Plasmodium vivax	vivapain-2	0.0031	0.086	0.1156
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.086	0.3201
Echinococcus granulosus	protein kinase c epsilon type	0.0046	0.1888	0.1888
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0036	0.1246	0.4636
Echinococcus multilocularis	synaptotagmin	0.0036	0.1246	0.1246
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.086	0.3201
Echinococcus multilocularis	protein piccolo	0.0036	0.1246	0.1246
Giardia lamblia	Cathepsin B precursor	0.0057	0.2688	0.5
Echinococcus granulosus	active breakpoint cluster region	0.0036	0.1246	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Echinococcus multilocularis	intersectin 2	0.0036	0.1246	0.1246
Schistosoma mansoni	glut4 vesicle protein-related	0.0036	0.1246	0.1246
Schistosoma mansoni	hypothetical protein	0.0036	0.1246	0.1246
Trypanosoma brucei	C2 domain containing protein, putative	0.0036	0.1246	0.4636
Loa Loa (eye worm)	cathepsin B	0.0057	0.2688	0.2482
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0031	0.086	0.0603
Entamoeba histolytica	hypothetical protein	0.0036	0.1246	0.985
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.086	0.086
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0036	0.1246	0.4636
Plasmodium vivax	perforin-like protein 2	0.0127	0.744	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.086	0.3201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0057	0.2688	1
Schistosoma mansoni	hypothetical protein	0.0127	0.744	0.744
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0036	0.1246	0.1246
Toxoplasma gondii	cathepsin B	0.0057	0.2688	0.2777
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0036	0.1246	0.1246
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Leishmania major	hypothetical protein, conserved	0.0036	0.1246	0.211
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Trichomonas vaginalis	copine, putative	0.0036	0.1246	0.4636
Loa Loa (eye worm)	copine family protein	0.0036	0.1246	0.1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0036	0.1246	0.1246
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0036	0.1246	0.4636
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0165	1	1
Schistosoma mansoni	otoferlin	0.0036	0.1246	0.1246
Leishmania major	hypothetical protein, conserved	0.0036	0.1246	0.211
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.086	0.086
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.1888	0.1888
Schistosoma mansoni	rho gtpase activating protein	0.0036	0.1246	0.1246
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1246	0.1246
Leishmania major	hypothetical protein, conserved	0.0036	0.1246	0.211
Trichomonas vaginalis	calcium-dependent lipid-binding protein, putative	0.0036	0.1246	0.4636
Brugia malayi	phospholipase C homolog	0.0036	0.1246	0.1246
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Trypanosoma brucei	predicted C2 domain protein	0.0036	0.1246	0.4636
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.086	0.3201
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0036	0.1246	0.1246
Onchocerca volvulus		0.0031	0.086	0.1364
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0036	0.1246	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Echinococcus granulosus	cathepsin b	0.0165	1	1
Brugia malayi	cathepsin L-like precursor	0.0022	0.0274	0.0274
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0274	0.0274
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.086	0.3201
Brugia malayi	Synaptotagmin protein 3	0.0036	0.1246	0.1246
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.0036	0.1246	0.1246
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Trypanosoma brucei	predicted C2 domain protein	0.0036	0.1246	0.4636
Schistosoma mansoni	synaptotagmin 12	0.0036	0.1246	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Trypanosoma brucei	Coiled-coil and C2 domain-containing protein	0.0036	0.1246	0.4636
Echinococcus granulosus	protein kinase C gamma type	0.0037	0.1265	0.1265
Trypanosoma brucei	C2 domain containing protein, putative	0.0036	0.1246	0.4636
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1246	0.1246
Trypanosoma cruzi	synaptotagmin, putative	0.0036	0.1246	0.1246
Schistosoma mansoni	synaptic ras gtpase activating protein syngap	0.0036	0.1246	0.1246
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Echinococcus multilocularis	copine 9	0.0036	0.1246	0.1246
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Entamoeba histolytica	C2 domain protein, putative	0.0036	0.1246	0.985
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0036	0.1246	0.1246
Entamoeba histolytica	hypothetical protein	0.0036	0.1246	0.985
Schistosoma mansoni	copine	0.0036	0.1246	0.1246
Echinococcus multilocularis	synaptotagmin protein 4	0.0036	0.1246	0.1246
Trypanosoma cruzi	C2 domain containing protein, putative	0.0036	0.1246	0.1246
Giardia lamblia	Cathepsin B precursor	0.0057	0.2688	0.5
Brugia malayi	Cathepsin L-like precursor	0.0031	0.086	0.086
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0274	0.0274
Entamoeba histolytica	C2 domain containing protein	0.0036	0.1246	0.985
Echinococcus multilocularis	unc 13 (munc13)	0.0046	0.1869	0.1869
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1246	0.1246
Entamoeba histolytica	C2 domain containing protein	0.0036	0.1246	0.985
Brugia malayi	Papain family cysteine protease containing protein	0.0031	0.086	0.086
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0046	0.1888	0.166
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.086	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.4406	0.4248
Echinococcus granulosus	synaptotagmin	0.0036	0.1246	0.1246
Onchocerca volvulus		0.0036	0.1246	0.226
Trypanosoma brucei	C2 domain containing protein, putative	0.0036	0.1246	0.4636
Entamoeba histolytica	calcium-binding protein, putative	0.0036	0.1246	0.985
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0031	0.086	0.086
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0046	0.1901	0.1901
Echinococcus granulosus	myoferlin	0.0036	0.1246	0.1246
Plasmodium vivax	ferlin, putative	0.0036	0.1246	0.1675
Loa Loa (eye worm)	hypothetical protein	0.0031	0.086	0.0603
Entamoeba histolytica	Rap/Ran GTPase activating protein, putative	0.0036	0.1246	0.985
Trichomonas vaginalis	synaptotagmin, putative	0.0036	0.1246	0.4636
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1869	0.1641
Trichomonas vaginalis	splicing factor 3A subunit, putative	0.0036	0.1246	0.4636
Trichomonas vaginalis	synaptotagmin, putative	0.0036	0.1246	0.4636
Leishmania major	hypothetical protein, conserved	0.0036	0.1246	0.211
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0039	0.1415	0.1174
Entamoeba histolytica	DENN domain protein	0.0036	0.1246	0.985
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0036	0.1246	0.1246
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Plasmodium falciparum	perforin-like protein 4	0.0127	0.744	1
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0036	0.1246	0.1246
Loa Loa (eye worm)	C2 domain-containing protein	0.0036	0.1246	0.1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Onchocerca volvulus	Cathepsin L homolog	0.0031	0.086	0.1364
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.086	0.3201
Echinococcus granulosus	NEDD4 E3 ubiquitin protein ligase WWP1	0.0036	0.1246	0.1246
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Onchocerca volvulus		0.0036	0.1246	0.226
Trichomonas vaginalis	synaptotagmin, putative	0.0036	0.1246	0.4636
Brugia malayi	Variant SH3 domain containing protein	0.0039	0.1415	0.1415
Echinococcus granulosus	otoferlin	0.0036	0.1246	0.1246
Trichomonas vaginalis	Circumsporozoite protein precursor, putative	0.0036	0.1246	0.4636
Entamoeba histolytica	protein kinase, putative	0.0037	0.1265	1
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0036	0.1246	0.4636
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Echinococcus granulosus	synaptotagmin	0.0036	0.1246	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.1246	0.4636
Toxoplasma gondii	hypothetical protein	0.0036	0.1246	0.0586
Toxoplasma gondii	perforin-like protein PLP1	0.0127	0.744	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Echinococcus granulosus	copine 9	0.0036	0.1246	0.1246
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Echinococcus multilocularis	extended synaptotagmin 2	0.0036	0.1246	0.1246
Echinococcus multilocularis	calpain 5	0.0036	0.1246	0.1246
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0036	0.1246	0.1246
Schistosoma mansoni	E3 ubiquitin-protein ligase nedd-4	0.0036	0.1246	0.1246
Trypanosoma brucei	cAMP binding protein, putative	0.0036	0.1246	0.4636
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Loa Loa (eye worm)	synaptotagmin-1	0.0036	0.1246	0.1
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Schistosoma mansoni	hypothetical protein	0.0036	0.1246	0.1246
Brugia malayi	C1-like domain containing protein	0.0083	0.4425	0.4425
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Onchocerca volvulus	Cathepsin F homolog	0.0031	0.086	0.1364
Schistosoma mansoni	synaptotagmin-like protein	0.0036	0.1246	0.1246
Schistosoma mansoni	synaptotagmin	0.0036	0.1246	0.1246
Loa Loa (eye worm)	C2 domain-containing protein	0.0036	0.1246	0.1
Schistosoma mansoni	hypothetical protein	0.0036	0.1246	0.1246
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0031	0.086	0.1156
Trichomonas vaginalis	copine, putative	0.0036	0.1246	0.4636
Echinococcus multilocularis	active breakpoint cluster region	0.0036	0.1246	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Brugia malayi	Cathepsin L-like precursor	0.0031	0.086	0.086
Loa Loa (eye worm)	fibroinase	0.0031	0.086	0.0603
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0274	0.1018
Leishmania major	hypothetical protein, conserved	0.0036	0.1246	0.211
Toxoplasma gondii	Sma protein	0.0036	0.1246	0.0586
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.086	0.6801
Echinococcus granulosus	cathepsin b	0.0165	1	1
Loa Loa (eye worm)	Nedd4-PD	0.0036	0.1246	0.1
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Toxoplasma gondii	phosphoinositide phospholipase PIPLC	0.0036	0.1246	0.0586
Trichomonas vaginalis	vab10 spectraplakin, putative	0.0036	0.1246	0.4636
Brugia malayi	Synapse defective protein 1	0.0036	0.1246	0.1246
Echinococcus multilocularis	neural cell expressed, developmentally	0.0036	0.1246	0.1246
Brugia malayi	Synaptotagmin I	0.0036	0.1246	0.1246
Trypanosoma cruzi	cruzipain precursor, putative	0.0031	0.086	0.086
Toxoplasma gondii	hypothetical protein	0.0036	0.1246	0.0586
Echinococcus granulosus	cathepsin l1	0.0022	0.0274	0.0274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0036	0.1246	0.1246
Echinococcus granulosus	Immunoglobulin E set	0.0036	0.1246	0.1246
Trypanosoma cruzi	cAMP binding protein, putative	0.0036	0.1246	0.1246
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.086	0.3201
Brugia malayi	Copine VIII	0.0036	0.1246	0.1246
Schistosoma mansoni	synaptotagmin	0.0036	0.1246	0.1246
Echinococcus multilocularis	protein kinase c epsilon type	0.0046	0.1888	0.1888
Plasmodium falciparum	perforin-like protein 2	0.0127	0.744	1
Schistosoma mansoni	protein kinase C	0.0046	0.1869	0.1869
Trypanosoma brucei	synaptotagmin, putative	0.0036	0.1246	0.4636
Loa Loa (eye worm)	hypothetical protein	0.0074	0.3782	0.3607
Echinococcus granulosus	synaptotagmin protein 4	0.0036	0.1246	0.1246
Entamoeba histolytica	cysteine protease, putative	0.0031	0.086	0.6801
Echinococcus granulosus	cathepsin l1	0.0031	0.086	0.086
Leishmania major	hypothetical protein, conserved	0.0036	0.1246	0.211
Leishmania major	c2 domain protein, putative	0.0036	0.1246	0.211
Leishmania major	copine i-like protein	0.0036	0.1246	0.211
Trypanosoma cruzi	Coiled-coil and C2 domain-containing protein	0.0036	0.1246	0.1246
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0046	0.1869	0.1869
Onchocerca volvulus		0.0036	0.1246	0.226
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0165	1	1
Loa Loa (eye worm)	C2 domain-containing protein	0.0036	0.1246	0.1
Toxoplasma gondii	Elicitor-responsive protein, putative	0.0036	0.1246	0.0586
Schistosoma mansoni	synaptotagmin 12	0.0036	0.1246	0.1246
Trypanosoma cruzi	C2 domain/Ankyrin repeats (3 copies), putative	0.0036	0.1246	0.1246
Schistosoma mansoni	protein kinase C mu	0.0083	0.4425	0.4425
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0036	0.1246	0.1246
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Leishmania major	hypothetical protein, conserved	0.0036	0.1246	0.211
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Schistosoma mansoni	synaptotagmin	0.0036	0.1246	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0165	1	1
Loa Loa (eye worm)	C2 domain-containing protein	0.0036	0.1246	0.1
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0036	0.1246	0.1246
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1246	0.1246
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0046	0.1888	0.1888
Plasmodium falciparum	perforin-like protein 1	0.0127	0.744	1
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Plasmodium vivax	perforin-like protein 5	0.0127	0.744	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1246	0.1246
Loa Loa (eye worm)	ctsf protein	0.0031	0.086	0.0603
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.086	0.3201
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1246	0.1246
Plasmodium vivax	perforin-like protein 3	0.0127	0.744	1
Onchocerca volvulus		0.0031	0.086	0.1364
Brugia malayi	Copine family protein	0.0036	0.1246	0.1246
Toxoplasma gondii	ferlin family protein	0.0036	0.1246	0.0586
Echinococcus multilocularis	cysteine protease	0.0031	0.086	0.086
Entamoeba histolytica	hypothetical protein	0.0036	0.1246	0.985
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0074	0.3801	0.3627
Entamoeba histolytica	hypothetical protein	0.0036	0.1246	0.985
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0165	1	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0036	0.1246	0.1246
Entamoeba histolytica	hypothetical protein	0.0036	0.1246	0.985
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0022	0.0274	0.0274
Toxoplasma gondii	C2 domain-containing protein	0.0036	0.1246	0.0586
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0057	0.2688	1
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0036	0.1246	0.1246
Echinococcus granulosus	Protein kinase C brain isozyme	0.0046	0.1888	0.1888
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.086	0.3201
Onchocerca volvulus		0.0036	0.1246	0.226
Schistosoma mansoni	cathepsin F (C01 family)	0.0031	0.086	0.086
Giardia lamblia	Cathepsin B precursor	0.0057	0.2688	0.5
Brugia malayi	LD23056p	0.0036	0.1246	0.1246
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.1888	0.1888
Trypanosoma brucei	predicted C2 domain protein	0.0036	0.1246	0.4636
Onchocerca volvulus		0.0036	0.1246	0.226
Onchocerca volvulus		0.0083	0.4406	0.9606
Echinococcus multilocularis	cathepsin L cysteine protease	0.0031	0.086	0.086
Trichomonas vaginalis	Proline-rich protein, putative	0.0036	0.1246	0.4636
Entamoeba histolytica	C2 domain containing protein	0.0036	0.1246	0.985
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0057	0.2688	0.2688
Loa Loa (eye worm)	C2 domain-containing protein	0.0036	0.1246	0.1
Echinococcus granulosus	macrophage expressed protein	0.0127	0.744	0.744
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0274	0.0274
Plasmodium falciparum	ferlin, putative	0.0036	0.1246	0.1675
Leishmania major	hypothetical protein, conserved	0.0036	0.1246	0.211
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0165	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.086	0.086
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0036	0.1246	0.1246
Echinococcus multilocularis	NEDD4 E3 ubiquitin protein ligase WWP1	0.0036	0.1246	0.1246
Echinococcus multilocularis	cathepsin b	0.0165	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Plasmodium vivax	perforin-like protein 4	0.0127	0.744	1
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Schistosoma mansoni	unc-13 (munc13)	0.0046	0.1869	0.1869
Entamoeba histolytica	C2 domain containing protein	0.0036	0.1246	0.985
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Brugia malayi	WW domain containing protein	0.0036	0.1246	0.1246
Entamoeba histolytica	protein kinase, putative	0.0037	0.1265	1
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0036	0.1246	0.1
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.1246	0.4636
Echinococcus multilocularis		0.0036	0.1246	0.1246
Chlamydia trachomatis	hypothetical protein	0.0127	0.744	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0036	0.1246	0.985
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Entamoeba histolytica	C2 domain containing protein	0.0036	0.1246	0.985
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0083	0.4425	0.4268
Trichomonas vaginalis	copine, putative	0.0036	0.1246	0.4636
Brugia malayi	calpain 5	0.0036	0.1246	0.1246
Schistosoma mansoni	unc-13 (munc13)	0.0036	0.1246	0.1246
Echinococcus multilocularis	synaptotagmin	0.0036	0.1246	0.1246
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.086	0.3201
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0031	0.086	0.1156
Schistosoma mansoni	synaptotagmin	0.0036	0.1246	0.1246
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.1246	0.1675
Plasmodium vivax	ferlin, putative	0.0036	0.1246	0.1675
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0031	0.086	0.086
Echinococcus multilocularis	synaptotagmin 15	0.0036	0.1246	0.1246
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0036	0.1246	0.1246
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0037	0.1265	0.1019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0031	0.086	0.3201
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0274	0.2164
Brugia malayi	Cathepsin L-like precursor	0.0031	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0031	0.086	0.3201
Echinococcus granulosus	synaptotagmin 15	0.0036	0.1246	0.1246
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.086	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0074	0.3782	0.3607
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0036	0.1246	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Loa Loa (eye worm)	cysteine protease	0.0031	0.086	0.0603
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.0036	0.1246	0.1
Schistosoma mansoni	nedd-4-like E3 ubiquitin-protein ligase	0.0036	0.1246	0.1246
Echinococcus multilocularis	synaptotagmin	0.0036	0.1246	0.1246
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0036	0.1246	0.4636
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0165	1	1
Trypanosoma brucei	C2 domain containing protein, putative	0.0036	0.1246	0.4636
Echinococcus multilocularis	cathepsin L cysteine protease	0.0031	0.086	0.086
Onchocerca volvulus	Cathepsin L homolog	0.0031	0.086	0.1364
Schistosoma mansoni	hypothetical protein	0.0036	0.1246	0.1246
Loa Loa (eye worm)	C2 domain-containing protein	0.0036	0.1246	0.1
Brugia malayi	Cathepsin L-like precursor	0.0031	0.086	0.086
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.1888	0.1888
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1246	0.1
Echinococcus granulosus	unc 13 munc13	0.0046	0.1869	0.1869
Echinococcus granulosus	synaptotagmin	0.0036	0.1246	0.1246
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0036	0.1246	0.1246
Schistosoma mansoni	rabphilin-3a	0.0036	0.1246	0.1246
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Onchocerca volvulus		0.0085	0.4575	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.086	0.086
Entamoeba histolytica	C2 domain containing protein	0.0036	0.1246	0.985
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0031	0.086	0.086
Onchocerca volvulus		0.0031	0.086	0.1364
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1246	0.1246
Trichomonas vaginalis	synaptotagmin, putative	0.0036	0.1246	0.4636
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.086	0.3201
Trichomonas vaginalis	annexin VII, putative	0.0036	0.1246	0.4636
Brugia malayi	Synapse defective protein 1	0.0036	0.1246	0.1246
Entamoeba histolytica	C2 domain containing protein	0.0036	0.1246	0.985
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0036	0.1246	0.1246
Echinococcus multilocularis	synaptotagmin	0.0036	0.1246	0.1246
Trichomonas vaginalis	copine, putative	0.0036	0.1246	0.4636
Onchocerca volvulus		0.0031	0.086	0.1364
Plasmodium vivax	vivapain-2	0.0031	0.086	0.1156
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0036	0.1246	0.1246
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0036	0.1246	0.1246
Brugia malayi	Cathepsin L-like precursor	0.0031	0.086	0.086
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.1246	0.4636
Leishmania major	phospholipase c-like protein	0.0036	0.1246	0.211
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.086	0.3201
Echinococcus multilocularis	cysteine protease	0.0031	0.086	0.086
Plasmodium vivax	double C2-like domain-containing protein, putative	0.0036	0.1246	0.1675
Echinococcus granulosus	synaptotagmin	0.0036	0.1246	0.1246
Brugia malayi	C2 domain containing protein	0.0036	0.1246	0.1246
Entamoeba histolytica	C2 domain containing protein	0.0036	0.1246	0.985
Onchocerca volvulus		0.0036	0.1246	0.226
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0036	0.1246	0.1246
Plasmodium falciparum	double C2-like domain-containing protein	0.0036	0.1246	0.1675

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.28 uM	Inhibition of human PKD1 by TR-FRET assay	ChEMBL.	21300545

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1683314

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1502344