TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 381.43 | Formula: C23H19N5O
H donors: 4 H acceptors: 2 LogP: 4.3 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1)Nc1ccc2c(c1)c(n[nH]2)c1cc2c([nH]1)cc(cc2)C
InChi: 1S/C23H19N5O/c1-14-7-8-15-12-21(26-20(15)11-14)22-18-13-17(9-10-19(18)27-28-22)25-23(29)24-16-5-3-2-4-6-16/h2-13,26H,1H3,(H,27,28)(H2,24,25,29)
InChiKey: PTXCIGRIVGVTTK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	IL2-inducible T-cell kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	Tyrosine-protein kinase BTK, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus granulosus	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.005	0.2612	0.9039
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.005	0.2612	0.2612
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.005	0.2612	0.2612
Echinococcus multilocularis	serine threonine protein kinase	0.005	0.2612	0.2612
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Loa Loa (eye worm)	C2 domain-containing protein	0.005	0.2612	0.9039
Onchocerca volvulus	Putative cc2d1b protein	0.005	0.2612	0.5
Entamoeba histolytica	protein kinase, putative	0.005	0.2612	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0007	0.005	0.005
Loa Loa (eye worm)	Nedd4-PD	0.005	0.2612	0.9039
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0007	0.005	0.005
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.005	0.2612	0.2612
Echinococcus multilocularis	active breakpoint cluster region	0.005	0.2612	0.2612
Loa Loa (eye worm)	C2 domain-containing protein	0.005	0.2612	0.9039
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Trypanosoma brucei	hypothetical protein, conserved	0.005	0.2612	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.005	0.2612	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.2612	0.5
Schistosoma mansoni	synaptotagmin	0.005	0.2612	0.2612
Trichomonas vaginalis	annexin VII, putative	0.005	0.2612	0.5
Echinococcus multilocularis	synaptotagmin 15	0.005	0.2612	0.2612
Plasmodium falciparum	perforin-like protein 2	0.0175	1	1
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.005	0.2612	0.2612
Leishmania major	copine i-like protein	0.005	0.2612	0.5
Entamoeba histolytica	C2 domain protein, putative	0.005	0.2612	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.2612	0.5
Trypanosoma cruzi	synaptotagmin, putative	0.005	0.2612	0.5
Trichomonas vaginalis	vab10 spectraplakin, putative	0.005	0.2612	0.5
Echinococcus multilocularis	myoferlin	0.005	0.2612	0.2612
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.005	0.2612	0.5
Schistosoma mansoni	synaptotagmin	0.005	0.2612	0.2612
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0007	0.005	0.005
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Entamoeba histolytica	hypothetical protein	0.005	0.2612	0.5
Echinococcus granulosus	protein kinase C gamma type	0.005	0.2612	0.2612
Entamoeba histolytica	C2 domain containing protein	0.005	0.2612	0.5
Leishmania major	c2 domain protein, putative	0.005	0.2612	0.5
Echinococcus multilocularis	synaptotagmin	0.005	0.2612	0.2612
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.005	0.005
Echinococcus granulosus	macrophage expressed protein	0.0175	1	1
Trypanosoma cruzi	C2 domain containing protein, putative	0.005	0.2612	0.5
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.005	0.2612	0.5
Echinococcus granulosus	protein piccolo	0.005	0.2612	0.2612
Entamoeba histolytica	protein kinase, putative	0.005	0.2612	0.5
Brugia malayi	Synapse defective protein 1	0.005	0.2612	0.9039
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Entamoeba histolytica	C2 domain containing protein	0.005	0.2612	0.5
Trypanosoma brucei	synaptotagmin, putative	0.005	0.2612	0.5
Entamoeba histolytica	hypothetical protein	0.005	0.2612	0.5
Echinococcus granulosus	calpain 5	0.005	0.2612	0.2612
Trypanosoma cruzi	Coiled-coil and C2 domain-containing protein	0.005	0.2612	0.5
Echinococcus granulosus	myoferlin	0.005	0.2612	0.2612
Plasmodium vivax	perforin-like protein 5	0.0175	1	1
Entamoeba histolytica	calcium-binding protein, putative	0.005	0.2612	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0007	0.005	0.005
Loa Loa (eye worm)	C2 domain-containing protein	0.005	0.2612	0.9039
Echinococcus granulosus	Protein kinase C brain isozyme	0.005	0.2612	0.2612
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Loa Loa (eye worm)	C2 domain-containing protein	0.005	0.2612	0.9039
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Schistosoma mansoni	glut4 vesicle protein-related	0.005	0.2612	0.2612
Brugia malayi	NEDD4.2	0.005	0.2612	0.9039
Loa Loa (eye worm)	C2 domain-containing protein	0.005	0.2612	0.9039
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.005	0.2612	0.2612
Trichomonas vaginalis	synaptotagmin, putative	0.005	0.2612	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0007	0.005	0.005
Trypanosoma cruzi	cAMP binding protein, putative	0.005	0.2612	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Brugia malayi	Synaptotagmin protein 3	0.005	0.2612	0.9039
Plasmodium vivax	perforin-like protein 1	0.0175	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Schistosoma mansoni	tyrosine kinase	0.0007	0.005	0.005
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.005	0.2612	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.2612	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Leishmania major	hypothetical protein, conserved	0.005	0.2612	0.5
Brugia malayi	phospholipase C homolog	0.005	0.2612	0.9039
Trichomonas vaginalis	synaptotagmin, putative	0.005	0.2612	0.5
Brugia malayi	Synaptotagmin I	0.005	0.2612	0.9039
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.005	0.2612	0.2612
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Entamoeba histolytica	C2 domain containing protein	0.005	0.2612	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.005	0.2612	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0055	0.289	1
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.005	0.2612	0.5
Brugia malayi	Synapse defective protein 1	0.005	0.2612	0.9039
Entamoeba histolytica	hypothetical protein	0.005	0.2612	0.5
Brugia malayi	Copine family protein	0.005	0.2612	0.9039
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.005	0.2612	0.9039
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0007	0.005	0.005
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0007	0.005	0.005
Trichomonas vaginalis	copine, putative	0.005	0.2612	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.005	0.2612	0.9039
Plasmodium vivax	perforin-like protein 4	0.0175	1	1
Echinococcus multilocularis	macrophage expressed protein	0.0175	1	1
Schistosoma mansoni	nedd-4-like E3 ubiquitin-protein ligase	0.005	0.2612	0.2612
Brugia malayi	LD23056p	0.005	0.2612	0.9039
Schistosoma mansoni	Mername-AA248 (C02 family)	0.005	0.2612	0.2612
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Trichomonas vaginalis	copine, putative	0.005	0.2612	0.5
Onchocerca volvulus		0.005	0.2612	0.5
Plasmodium vivax	perforin-like protein 2	0.0175	1	1
Trypanosoma brucei	predicted C2 domain protein	0.005	0.2612	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.2612	0.5
Plasmodium falciparum	perforin-like protein 4	0.0175	1	1
Entamoeba histolytica	C2 domain containing protein	0.005	0.2612	0.5
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.005	0.2612	0.9039
Echinococcus granulosus	Immunoglobulin E set	0.005	0.2612	0.2612
Trichomonas vaginalis	copine, putative	0.005	0.2612	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Trichomonas vaginalis	synaptotagmin, putative	0.005	0.2612	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Echinococcus multilocularis	synaptotagmin	0.005	0.2612	0.2612
Echinococcus multilocularis	UNCoordinated family member (unc 13)	0.005	0.2612	0.2612
Schistosoma mansoni	E3 ubiquitin-protein ligase nedd-4	0.005	0.2612	0.2612
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0007	0.005	0.005
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.2612	0.5
Onchocerca volvulus		0.005	0.2612	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.2612	0.2612
Entamoeba histolytica	hypothetical protein, conserved	0.005	0.2612	0.5
Echinococcus granulosus	synaptotagmin 2	0.005	0.2612	0.2612
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Leishmania major	hypothetical protein, conserved	0.005	0.2612	0.5
Entamoeba histolytica	hypothetical protein	0.005	0.2612	0.5
Echinococcus multilocularis	neural cell expressed, developmentally	0.005	0.2612	0.2612
Onchocerca volvulus		0.005	0.2612	0.5
Echinococcus multilocularis	protein kinase c epsilon type	0.005	0.2612	0.2612
Trichomonas vaginalis	ion channel nompc, putative	0.005	0.2612	0.5
Echinococcus granulosus	synaptotagmin protein 4	0.005	0.2612	0.2612
Echinococcus granulosus	NEDD4 E3 ubiquitin protein ligase WWP1	0.005	0.2612	0.2612
Schistosoma mansoni	mctp-related	0.005	0.2612	0.2612
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0007	0.005	0.005
Echinococcus multilocularis	synaptotagmin protein 4	0.005	0.2612	0.2612
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Echinococcus granulosus	copine 9	0.005	0.2612	0.2612
Trichomonas vaginalis	copine, putative	0.005	0.2612	0.5
Leishmania major	hypothetical protein, conserved	0.005	0.2612	0.5
Echinococcus granulosus	copine 9	0.005	0.2612	0.2612
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.005	0.2612	0.9039
Trichomonas vaginalis	synaptotagmin, putative	0.005	0.2612	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0007	0.005	0.005
Schistosoma mansoni	hypothetical protein	0.005	0.2612	0.2612
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.005	0.2612	0.9039
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.005	0.2612	0.5
Entamoeba histolytica	C2 domain containing protein	0.005	0.2612	0.5
Schistosoma mansoni	hypothetical protein	0.005	0.2612	0.2612
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.005	0.2612	0.2612
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.005	0.2612	0.5
Schistosoma mansoni	synaptotagmin	0.005	0.2612	0.2612
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.2612	0.2612
Plasmodium falciparum	perforin-like protein 1	0.0175	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0007	0.005	0.005
Trypanosoma brucei	cAMP binding protein, putative	0.005	0.2612	0.5
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Leishmania major	phospholipase c-like protein	0.005	0.2612	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.005	0.2612	0.5
Trypanosoma brucei	C2 domain containing protein, putative	0.005	0.2612	0.5
Echinococcus granulosus	intersectin 2	0.0053	0.2787	0.2787
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.2612	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Echinococcus granulosus	extended synaptotagmin 2	0.005	0.2612	0.2612
Schistosoma mansoni	synaptotagmin	0.005	0.2612	0.2612
Echinococcus granulosus	synaptotagmin	0.005	0.2612	0.2612
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.005	0.2612	0.2612
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0167	0.9554	0.9554
Schistosoma mansoni	synaptotagmin-like protein	0.005	0.2612	0.2612
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0007	0.005	0.005
Echinococcus granulosus	synaptotagmin	0.005	0.2612	0.2612
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Brugia malayi	SRC-1	0.0007	0.005	0.0175
Leishmania major	hypothetical protein, conserved	0.005	0.2612	0.5
Schistosoma mansoni	rabphilin-3a	0.005	0.2612	0.2612
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.005	0.2612	0.2612
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.005	0.2612	0.2612
Trypanosoma brucei	C2 domain containing protein, putative	0.005	0.2612	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0007	0.005	0.005
Brugia malayi	Protein kinase c protein 2	0.005	0.2612	0.9039
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.005	0.2612	0.2612
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0007	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.005	0.2612	0.2612
Echinococcus multilocularis		0.005	0.2612	0.2612
Brugia malayi	Variant SH3 domain containing protein	0.0055	0.289	1
Trypanosoma brucei	C2 domain containing protein, putative	0.005	0.2612	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Entamoeba histolytica	DENN domain protein	0.005	0.2612	0.5
Leishmania major	hypothetical protein, conserved	0.005	0.2612	0.5
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.005	0.2612	0.2612
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.005	0.2612	0.5
Echinococcus granulosus	protein kinase c epsilon type	0.005	0.2612	0.2612
Toxoplasma gondii	perforin-like protein PLP1	0.0175	1	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.005	0.005
Schistosoma mansoni	unc-13 (munc13)	0.005	0.2612	0.2612
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Echinococcus granulosus	synaptotagmin	0.005	0.2612	0.2612
Schistosoma mansoni	tyrosine kinase	0.0007	0.005	0.005
Schistosoma mansoni	hypothetical protein	0.005	0.2612	0.2612
Echinococcus granulosus	synaptotagmin 15	0.005	0.2612	0.2612
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Brugia malayi	WW domain containing protein	0.005	0.2612	0.9039
Schistosoma mansoni	synaptotagmin	0.005	0.2612	0.2612
Schistosoma mansoni	otoferlin	0.005	0.2612	0.2612
Trichomonas vaginalis	splicing factor 3A subunit, putative	0.005	0.2612	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Echinococcus multilocularis	calpain 5	0.005	0.2612	0.2612
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Onchocerca volvulus		0.005	0.2612	0.5
Entamoeba histolytica	C2 domain containing protein	0.005	0.2612	0.5
Trypanosoma brucei	C2 domain/Ankyrin repeats (3 copies), putative	0.005	0.2612	0.5
Echinococcus granulosus	neural cell expressed developmentally	0.005	0.2612	0.2612
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.005	0.2612	0.2612
Leishmania major	hypothetical protein, conserved	0.005	0.2612	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0007	0.005	0.005
Onchocerca volvulus		0.005	0.2612	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0007	0.005	0.0175
Plasmodium falciparum	perforin-like protein 3	0.0175	1	1
Trypanosoma brucei	predicted C2 domain protein	0.005	0.2612	0.5
Trypanosoma brucei	predicted C2 domain protein	0.005	0.2612	0.5
Trichomonas vaginalis	Proline-rich protein, putative	0.005	0.2612	0.5
Trichomonas vaginalis	copine, putative	0.005	0.2612	0.5
Schistosoma mansoni	tyrosine kinase	0.0007	0.005	0.005
Trichomonas vaginalis	calcium-dependent lipid-binding protein, putative	0.005	0.2612	0.5
Echinococcus granulosus	active breakpoint cluster region	0.005	0.2612	0.2612
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Brugia malayi	Copine VIII	0.005	0.2612	0.9039
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.2612	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0007	0.005	0.005
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.005	0.005
Schistosoma mansoni	copine	0.005	0.2612	0.2612
Echinococcus multilocularis	synaptotagmin	0.005	0.2612	0.2612
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Schistosoma mansoni	protein kinase C	0.005	0.2612	0.2612
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.2612	0.2612
Brugia malayi	calpain 5	0.005	0.2612	0.9039
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.005	0.2612	0.9039
Schistosoma mansoni	synaptic ras gtpase activating protein syngap	0.005	0.2612	0.2612
Trypanosoma brucei	hypothetical protein, conserved	0.005	0.2612	0.5
Echinococcus granulosus	UNCoordinated family member unc 13	0.005	0.2612	0.2612
Echinococcus granulosus	otoferlin	0.005	0.2612	0.2612
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.005	0.2612	0.2612
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Schistosoma mansoni	fer-1-related	0.005	0.2612	0.2612
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Schistosoma mansoni	unc-13 (munc13)	0.005	0.2612	0.2612
Echinococcus multilocularis	synaptotagmin	0.005	0.2612	0.2612
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.005	0.2612	0.5
Loa Loa (eye worm)	synaptotagmin-1	0.005	0.2612	0.9039
Onchocerca volvulus		0.005	0.2612	0.5
Echinococcus granulosus	c src tyrosine kinase	0.0007	0.005	0.005
Schistosoma mansoni	tyrosine kinase	0.0164	0.9379	0.9379
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.005	0.2612	0.2612
Trichomonas vaginalis	synaptotagmin, putative	0.005	0.2612	0.5
Echinococcus multilocularis	synaptotagmin	0.005	0.2612	0.2612
Echinococcus multilocularis	unc 13 (munc13)	0.005	0.2612	0.2612
Plasmodium vivax	perforin-like protein 3	0.0175	1	1
Trypanosoma brucei	C2 domain containing protein, putative	0.005	0.2612	0.5
Echinococcus granulosus	unc 13 munc13	0.005	0.2612	0.2612
Echinococcus granulosus	synaptotagmin	0.005	0.2612	0.2612
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Entamoeba histolytica	C2 domain containing protein	0.005	0.2612	0.5
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Entamoeba histolytica	C2 domain containing protein	0.005	0.2612	0.5
Onchocerca volvulus		0.005	0.2612	0.5
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Echinococcus multilocularis	copine 9	0.005	0.2612	0.2612
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.005	0.2612	0.2612
Leishmania major	c2 domain protein, putative	0.005	0.2612	0.5
Schistosoma mansoni	hypothetical protein	0.005	0.2612	0.2612
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Schistosoma mansoni	synaptotagmin	0.005	0.2612	0.2612
Trypanosoma cruzi	synaptotagmin, putative	0.005	0.2612	0.5
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.005	0.2612	0.2612
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Schistosoma mansoni	tyrosine kinase	0.0007	0.005	0.005
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.005	0.2612	0.2612
Schistosoma mansoni	unc-13 (munc13)	0.005	0.2612	0.2612
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Echinococcus multilocularis	protein piccolo	0.005	0.2612	0.2612
Schistosoma mansoni	rho gtpase activating protein	0.005	0.2612	0.2612
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0167	0.9554	0.9554
Loa Loa (eye worm)	copine family protein	0.005	0.2612	0.9039
Leishmania major	hypothetical protein, conserved	0.005	0.2612	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Echinococcus multilocularis	intersectin 2	0.0053	0.2787	0.2787
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0007	0.005	0.005
Schistosoma mansoni	hypothetical protein	0.005	0.2612	0.2612
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Plasmodium falciparum	perforin-like protein 5	0.0175	1	1
Echinococcus multilocularis	synaptotagmin 2	0.005	0.2612	0.2612
Entamoeba histolytica	hypothetical protein, conserved	0.005	0.2612	0.5
Entamoeba histolytica	hypothetical protein	0.005	0.2612	0.5
Echinococcus multilocularis	NEDD4 E3 ubiquitin protein ligase WWP1	0.005	0.2612	0.2612
Brugia malayi	C2 domain containing protein	0.005	0.2612	0.9039
Schistosoma mansoni	synaptotagmin 12	0.005	0.2612	0.2612
Entamoeba histolytica	hypothetical protein	0.005	0.2612	0.5
Loa Loa (eye worm)	SRC-1	0.0007	0.005	0.0175
Toxoplasma gondii	MAC/Perforin domain-containing protein	0.0175	1	1
Echinococcus multilocularis	copine 9	0.005	0.2612	0.2612
Onchocerca volvulus	Multiple C2 domain and transmembrane region protein homolog	0.005	0.2612	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.005	0.2612	0.5
Echinococcus granulosus	synaptotagmin	0.005	0.2612	0.2612
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.005	0.2612	0.2612
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.005	0.2612	0.2612
Trypanosoma cruzi	C2 domain/Ankyrin repeats (3 copies), putative	0.005	0.2612	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.2612	0.5
Onchocerca volvulus		0.005	0.2612	0.5
Entamoeba histolytica	C2 domain containing protein	0.005	0.2612	0.5
Schistosoma mansoni	synaptotagmin 12	0.005	0.2612	0.2612
Leishmania major	hypothetical protein, conserved	0.005	0.2612	0.5
Echinococcus multilocularis	extended synaptotagmin 2	0.005	0.2612	0.2612
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.005	0.2612	0.2612
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.005	0.2612	0.2612
Trichomonas vaginalis	Circumsporozoite protein precursor, putative	0.005	0.2612	0.5
Entamoeba histolytica	Rap/Ran GTPase activating protein, putative	0.005	0.2612	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.2612	0.9039
Brugia malayi	protein kinase C II.	0.005	0.2612	0.9039
Schistosoma mansoni	hypothetical protein	0.0175	1	1
Trypanosoma brucei	Coiled-coil and C2 domain-containing protein	0.005	0.2612	0.5
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.005	0.2612	0.2612

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.73 uM	Inhibition of recombinant GST-tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay	ChEMBL.	21316219

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1684530

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1502347