Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0824 | 0.358 | 0.358 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0484 | 0.1258 | 0.1258 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Mycobacterium ulcerans | polyprenyl diphosphate synthetase, GrcC1 | 0.0824 | 0.358 | 0.2185 |
Loa Loa (eye worm) | hypothetical protein | 0.0879 | 0.3955 | 0.3955 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0484 | 0.1258 | 0.1258 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0824 | 0.358 | 0.5 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0561 | 0.1785 | 0.5 |
Schistosoma mansoni | trans-prenyltransferase | 0.0824 | 0.358 | 0.358 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Plasmodium falciparum | octaprenyl pyrophosphate synthase | 0.0824 | 0.358 | 0.358 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0561 | 0.1785 | 0.1785 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0824 | 0.358 | 1 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.1765 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0484 | 0.1258 | 0.1258 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.1765 | 1 | 0.5 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0484 | 0.1258 | 0.1258 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.1765 | 1 | 1 |
Trypanosoma brucei | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0824 | 0.358 | 0.358 |
Schistosoma mansoni | glutathione synthetase | 0.0561 | 0.1785 | 0.1785 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.064 | 0.2324 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0565 | 0.1815 | 0.1815 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.064 | 0.2324 | 0.2324 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1765 | 1 | 1 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0484 | 0.1258 | 0.1258 |
Echinococcus granulosus | carbonic anhydrase II | 0.0484 | 0.1258 | 0.1258 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0824 | 0.358 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.0824 | 0.358 | 0.2656 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0824 | 0.358 | 0.358 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0484 | 0.1258 | 0.1258 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0824 | 0.358 | 1 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.1765 | 1 | 1 |
Leishmania major | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0824 | 0.358 | 0.358 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0824 | 0.358 | 0.358 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.1765 | 1 | 0.5 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0561 | 0.1785 | 0.1785 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0484 | 0.1258 | 0.1258 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Leishmania major | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.064 | 0.2324 | 0.2324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.