Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0561 | 0.1785 | 0.5 |
Schistosoma mansoni | trans-prenyltransferase | 0.0824 | 0.358 | 0.358 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0824 | 0.358 | 0.5 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0561 | 0.1785 | 0.1785 |
Plasmodium falciparum | octaprenyl pyrophosphate synthase | 0.0824 | 0.358 | 0.358 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0824 | 0.358 | 0.358 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0484 | 0.1258 | 0.1258 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0484 | 0.1258 | 0.1258 |
Mycobacterium ulcerans | polyprenyl diphosphate synthetase, GrcC1 | 0.0824 | 0.358 | 0.2185 |
Loa Loa (eye worm) | hypothetical protein | 0.0879 | 0.3955 | 0.3955 |
Schistosoma mansoni | glutathione synthetase | 0.0561 | 0.1785 | 0.1785 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0824 | 0.358 | 0.358 |
Trypanosoma brucei | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.064 | 0.2324 | 0.5 |
Brugia malayi | hypothetical protein | 0.0565 | 0.1815 | 0.1815 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.064 | 0.2324 | 0.2324 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0484 | 0.1258 | 0.1258 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0824 | 0.358 | 1 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.1765 | 1 | 1 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.1765 | 1 | 1 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.1765 | 1 | 0.5 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0484 | 0.1258 | 0.1258 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 1 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.1765 | 1 | 1 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0824 | 0.358 | 1 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0824 | 0.358 | 0.358 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0824 | 0.358 | 0.358 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.1765 | 1 | 0.5 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0561 | 0.1785 | 0.1785 |
Leishmania major | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1765 | 1 | 1 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0824 | 0.358 | 0.358 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0484 | 0.1258 | 0.1258 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0824 | 0.358 | 1 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0484 | 0.1258 | 0.1258 |
Echinococcus granulosus | carbonic anhydrase II | 0.0484 | 0.1258 | 0.1258 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.0824 | 0.358 | 0.2656 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.064 | 0.2324 | 0.2324 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0484 | 0.1258 | 0.1258 |
Leishmania major | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.