Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.017 | 0.0165 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0004 | 0.0015 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.017 | 0.0165 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.017 | 0.017 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.017 | 0.057 |
Loa Loa (eye worm) | transcriptional regulator | 0.017 | 0.1992 | 0.1988 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.017 | 0.0165 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.017 | 0.057 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 6 | 0.017 | 0.1992 | 0.1933 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.017 | 0.2538 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0065 | 0.0573 | 0.0573 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.017 | 0.0165 |
Leishmania major | NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe | 0.0242 | 0.2974 | 0.2974 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0759 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0501 | 0.1686 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0759 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.2481 | 0.2478 |
Onchocerca volvulus | 0.0036 | 0.017 | 0.0577 | |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0004 | 0.0004 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0573 | 0.041 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0004 | 0.0015 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0393 | 0.5029 | 0.4943 |
Loa Loa (eye worm) | transcriptional regulator | 0.017 | 0.1992 | 0.1988 |
Leishmania major | silent information regulator 2, putative | 0.0759 | 1 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.017 | 0.057 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.017 | 0.057 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0393 | 0.5029 | 0.4943 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0393 | 0.5029 | 0.4943 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.017 | 0.0083 |
Trypanosoma cruzi | Silent information regulator 2 related protein 3 | 0.0242 | 0.2974 | 0.2852 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0759 | 1 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0087 | 0.0015 |
Onchocerca volvulus | 0.0234 | 0.2867 | 1 | |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0573 | 0.0568 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0803 | 0.0799 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0393 | 0.5029 | 0.4986 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0065 | 0.0573 | 0.0568 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0501 | 0.1686 |
Plasmodium falciparum | transcriptional regulatory protein sir2b | 0.017 | 0.1992 | 0.6697 |
Giardia lamblia | Transcriptional regulator, Sir2 family | 0.0242 | 0.2974 | 0.1226 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0087 | 0.0083 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.017 | 0.1992 | 0.1921 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.017 | 0.057 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.017 | 0.017 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.017 | 0.057 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.017 | 0.057 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.017 | 0.1992 | 0.1853 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0759 | 1 | 1 |
Mycobacterium ulcerans | NAD-dependent deacetylase | 0.0242 | 0.2974 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.017 | 0.0165 |
Leishmania major | sir2-family protein-like protein | 0.017 | 0.1992 | 0.1992 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0004 | 0.0015 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.017 | 0.057 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.5029 | 0.5027 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0759 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0501 | 0.0501 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0759 | 1 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.017 | 0.057 |
Trypanosoma brucei | Silent information regulator 2 related protein 3 | 0.0242 | 0.2974 | 0.2974 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0004 | 0.0015 |
Entamoeba histolytica | NAD-dependent deacetylase 1, putative | 0.017 | 0.1992 | 0.1992 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.017 | 0.1992 | 0.1921 |
Onchocerca volvulus | 0.0036 | 0.017 | 0.0577 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.017 | 0.0165 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0573 | 0.041 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0004 | 0.0015 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0004 | 0.0004 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0501 | 0.1686 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.017 | 0.057 |
Onchocerca volvulus | 0.0036 | 0.017 | 0.0577 | |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.017 | 0.1992 | 0.1853 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0759 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.017 | 0.0165 |
Brugia malayi | beta-lactamase | 0.0036 | 0.017 | 0.0165 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.2775 | 0.9334 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.017 | 0.2538 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0393 | 0.5029 | 0.4986 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0759 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.017 | 0.0083 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0004 | 0.0004 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 6 | 0.017 | 0.1992 | 0.1921 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.2481 | 0.2478 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0242 | 0.2974 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.017 | 0.057 |
Loa Loa (eye worm) | transcriptional regulator | 0.0759 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0501 | 0.0418 |
Toxoplasma gondii | histone deacetylase SIR2-like | 0.017 | 0.1992 | 0.6697 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0682 | 0.8954 | 0.8945 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0004 | 0.0004 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0082 | 0.0803 | 0.0722 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0004 | 0.0004 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0199 | 0.0113 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0004 | 0.0015 |
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.0393 | 0.5029 | 0.3793 |
Plasmodium vivax | hypothetical protein, conserved | 0.017 | 0.1992 | 0.6697 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0004 | 0.0065 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0082 | 0.0803 | 0.0799 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.017 | 0.057 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0501 | 0.0418 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0242 | 0.2974 | 0.2974 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 7 | 0.017 | 0.1992 | 0.1933 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0004 | 0.0015 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0759 | 1 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.017 | 0.057 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.017 | 0.057 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.017 | 0.1992 | 0.1988 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0759 | 1 | 1 |
Brugia malayi | transcriptional regulator, Sir2 family protein | 0.017 | 0.1992 | 0.1988 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0087 | 0.0083 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.017 | 0.0098 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0087 | 0.0292 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0759 | 1 | 1 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0242 | 0.2974 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0004 | 0.0015 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0242 | 0.2974 | 0.2852 |
Mycobacterium leprae | Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) | 0.0072 | 0.0668 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0242 | 0.2974 | 0.2852 |
Brugia malayi | NAD-dependent deacetylase SIRT1 | 0.0393 | 0.5029 | 0.5027 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0082 | 0.0803 | 0.0736 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.0573 | 0.0573 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.017 | 0.0083 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.017 | 0.057 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0199 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.2724 | 0.272 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0501 | 0.0418 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0082 | 0.0803 | 0.0722 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0759 | 1 | 1 |
Trypanosoma brucei | SIR2-like protein 4, putative | 0.017 | 0.1992 | 0.1992 |
Onchocerca volvulus | 0.0082 | 0.0803 | 0.2788 | |
Mycobacterium ulcerans | Sir2-like regulatory protein | 0.017 | 0.1992 | 0.6697 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0501 | 0.1686 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0004 | 0.0015 |
Toxoplasma gondii | histone deacetylase SIR2 | 0.0242 | 0.2974 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.017 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.017 | 0.0165 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0065 | 0.0573 | 0.0573 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0393 | 0.5029 | 0.4943 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0242 | 0.2974 | 0.2912 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0501 | 0.1686 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0087 | 0.0292 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0759 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0242 | 0.2974 | 0.2852 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0501 | 0.0432 |
Trichomonas vaginalis | set domain proteins, putative | 0.0234 | 0.2867 | 0.2744 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.017 | 0.0165 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.017 | 0.0165 |
Onchocerca volvulus | 0.003 | 0.0087 | 0.0288 | |
Trypanosoma cruzi | Silent information regulator 2 related protein 3 | 0.0242 | 0.2974 | 0.2852 |
Giardia lamblia | Hypothetical protein | 0.0759 | 1 | 1 |
Loa Loa (eye worm) | sirtuin 4 | 0.017 | 0.1992 | 0.1988 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0682 | 0.8954 | 0.8947 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0759 | 1 | 1 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0242 | 0.2974 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0004 | 0.0065 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0573 | 0.049 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.017 | 0.057 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0004 | 0.0015 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.017 | 0.057 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0682 | 0.8954 | 0.8945 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0393 | 0.5029 | 0.4993 |
Entamoeba histolytica | hypothetical protein, conserved | 0.017 | 0.1992 | 0.1992 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.0573 | 0.0504 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 7 | 0.017 | 0.1992 | 0.1921 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.0573 | 0.049 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 76 % | Inhibition of recombinant HIV-1 protease at 50 nM | ChEMBL. | 21316958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.