Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0152 | 0.0401 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.1261 | 0.1261 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.1261 | 0.3332 |
Onchocerca volvulus | Dual oxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Plasmodium vivax | cytochrome b | 0.0128 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Echinococcus granulosus | cytochrome B | 0.0128 | 0.2617 | 0.2617 |
Echinococcus granulosus | peroxidasin | 0.0177 | 0.3712 | 0.3712 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0463 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.1261 | 0.3332 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0152 | 0.0401 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0813 | 0.0813 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0152 | 0.0152 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0181 | 0.3784 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0903 | 0.2387 |
Brugia malayi | N-terminal motif family protein | 0.0181 | 0.3784 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0128 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0555 | 0.1468 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0813 | 0.0813 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0152 | 0.0152 |
Onchocerca volvulus | Peroxidasin homolog | 0.0177 | 0.3712 | 0.9809 |
Toxoplasma gondii | cytochrome b | 0.0128 | 0.2617 | 1 |
Brugia malayi | Peroxidasin | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3784 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.1261 | 0.1261 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0813 | 0.0813 |
Onchocerca volvulus | Peroxidasin homolog | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.1261 | 0.3332 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.1261 | 0.3332 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0813 | 0.2147 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Plasmodium falciparum | cytochrome b | 0.0128 | 0.2617 | 0.5 |
Toxoplasma gondii | apocytochrome b, putative | 0.0128 | 0.2617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0903 | 0.2387 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0152 | 0.0401 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0152 | 0.0152 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | cytochrome b | 0.0128 | 0.2617 | 0.6914 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0813 | 0.0813 |
Onchocerca volvulus | Peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | peroxidasin | 0.0177 | 0.3712 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Brugia malayi | Blistered cuticle protein 3 | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Schistosoma mansoni | peroxidasin | 0.0177 | 0.3712 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.1261 | 0.3332 |
Brugia malayi | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | Peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0463 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0555 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0463 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0152 | 0.0401 |
Schistosoma mansoni | cytochrome b | 0.0128 | 0.2617 | 0.7049 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0903 | 0.2387 |
Echinococcus multilocularis | peroxidasin | 0.0177 | 0.3712 | 0.3712 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0152 | 0.0152 |
Schistosoma mansoni | cytochrome b | 0.0128 | 0.2617 | 0.7049 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0813 | 0.2147 |
Brugia malayi | RNA binding protein | 0.0066 | 0.1261 | 0.3332 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0903 | 0.2387 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0555 | 0.1468 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | cytochrome b | 0.0128 | 0.2617 | 0.6914 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 428.5 nM | Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
IC50 (functional) | = 1298.1 nM | Antimalarial activity against chloroquine-,pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
IC50 (functional) | = 2605.1 nM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 21316974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.