Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1765 | 1 | 1 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0824 | 0.358 | 0.358 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0484 | 0.1258 | 0.1258 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.0824 | 0.358 | 0.2656 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0484 | 0.1258 | 0.1258 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0824 | 0.358 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0484 | 0.1258 | 0.1258 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.1765 | 1 | 1 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0824 | 0.358 | 1 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.1765 | 1 | 0.5 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0561 | 0.1785 | 0.1785 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0824 | 0.358 | 0.358 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0824 | 0.358 | 0.358 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Leishmania major | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 0.5 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.064 | 0.2324 | 0.2324 |
Leishmania major | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0484 | 0.1258 | 0.1258 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0484 | 0.1258 | 0.1258 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0824 | 0.358 | 0.358 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0484 | 0.1258 | 0.1258 |
Loa Loa (eye worm) | hypothetical protein | 0.0879 | 0.3955 | 0.3955 |
Mycobacterium ulcerans | polyprenyl diphosphate synthetase, GrcC1 | 0.0824 | 0.358 | 0.2185 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0561 | 0.1785 | 0.5 |
Schistosoma mansoni | trans-prenyltransferase | 0.0824 | 0.358 | 0.358 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0824 | 0.358 | 0.5 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0561 | 0.1785 | 0.1785 |
Plasmodium falciparum | octaprenyl pyrophosphate synthase | 0.0824 | 0.358 | 0.358 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0484 | 0.1258 | 0.1258 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0824 | 0.358 | 1 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.1765 | 1 | 1 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.1765 | 1 | 1 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0484 | 0.1258 | 0.1258 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 1 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.1765 | 1 | 0.5 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.064 | 0.2324 | 0.5 |
Schistosoma mansoni | glutathione synthetase | 0.0561 | 0.1785 | 0.1785 |
Trypanosoma brucei | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0824 | 0.358 | 0.358 |
Brugia malayi | hypothetical protein | 0.0565 | 0.1815 | 0.1815 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.064 | 0.2324 | 0.2324 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.