TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.437 | Formula: C16H33NO5
H donors: 4 H acceptors: 4 LogP: 0.83 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCOCCCCCN1C[C@H](O)[C@H]([C@@H]([C@H]1CO)O)O
InChi: 1S/C16H33NO5/c1-2-3-6-9-22-10-7-4-5-8-17-11-14(19)16(21)15(20)13(17)12-18/h13-16,18-21H,2-12H2,1H3/t13-,14+,15-,16-/m1/s1
InChiKey: LLUQYJRYJAPGMA-QKPAOTATSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	glucosidase, alpha, acid	Starlite/ChEMBL	References
Mus musculus	sucrase isomaltase (alpha-glucosidase)	Starlite/ChEMBL	References
Mus musculus	UDP-glucose ceramide glucosyltransferase	Starlite/ChEMBL	References
Homo sapiens	glucosidase, beta (bile acid) 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Non-lysosomal glucosylceramidase, putative	Get druggable targets OG5_130651	All targets in OG5_130651
Schistosoma mansoni	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Schistosoma mansoni	bile acid beta-glucosidase-related	Get druggable targets OG5_130651	All targets in OG5_130651
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Candida albicans	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	bile acid beta glucosidase	Get druggable targets OG5_130651	All targets in OG5_130651
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Loa Loa (eye worm)	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	non lysosomal glucosylceramidase	Get druggable targets OG5_130651	All targets in OG5_130651
Onchocerca volvulus	Ceramide glucosyltransferase homolog	Get druggable targets OG5_129848	All targets in OG5_129848
Schistosoma japonicum	Non-lysosomal glucosylceramidase, putative	Get druggable targets OG5_130651	All targets in OG5_130651
Brugia malayi	Ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	bile acid beta-glucosidase-related	Get druggable targets OG5_130651	All targets in OG5_130651
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K00720 ceramide glucosyltransferase [EC2.4.1.80], putative	Get druggable targets OG5_129848	All targets in OG5_129848
Schistosoma japonicum	Non-lysosomal glucosylceramidase, putative	Get druggable targets OG5_130651	All targets in OG5_130651
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Schistosoma japonicum	Ceramide glucosyltransferase, putative	Get druggable targets OG5_129848	All targets in OG5_129848
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130651	All targets in OG5_130651
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	bile acid beta glucosidase	Get druggable targets OG5_130651	All targets in OG5_130651
Echinococcus granulosus	non lysosomal glucosylceramidase	Get druggable targets OG5_130651	All targets in OG5_130651

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Reprolysin	0.0116	0.1139	0.1135
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0056	0.2928
Trichomonas vaginalis	rotamase, putative	0.007	0.0582	0.733
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0143	0.172
Onchocerca volvulus		0.0035	0.0173	0.0188
Echinococcus multilocularis	expressed protein	0.0071	0.0603	0.0645
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.017	0.2068
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0278	0.0274
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0044	0.0278	0.3445
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0798	0.9272	1
Schistosoma mansoni	ADAMTS14 peptidase (M12 family)	0.0116	0.1139	0.2789
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.0022	0.001	0.5
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0044	0.0278	0.3445
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0087	0.0792	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0169
Echinococcus multilocularis	muscleblind protein 1	0.0295	0.3262	0.3515
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0035	0.0343
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0033	0.0138	0.1662
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0147	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2689	0.2685
Schistosoma mansoni	bile acid beta-glucosidase-related	0.0251	0.2748	0.6743
Entamoeba histolytica	hypothetical protein	0.0076	0.0655	0.8255
Brugia malayi	hypothetical protein	0.0775	0.8986	0.8986
Toxoplasma gondii	ABC1 family protein	0.0035	0.0173	0.2108
Entamoeba histolytica	hypothetical protein	0.0024	0.0034	0.0334
Brugia malayi	ADAMTS-like protease	0.0264	0.2894	0.2891
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0173	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0147	0.0143
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0033	0.0138	0.1747
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0143	0.172
Giardia lamblia	Ceramide glucosyltransferase	0.0131	0.1308	1
Leishmania major	alpha glucosidase II subunit, putative	0.0087	0.0792	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0056	0.0617
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0143	0.172
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0071	0.0603	0.0598
Echinococcus granulosus	non lysosomal glucosylceramidase	0.0251	0.2748	0.6181
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.007	0.0582	0.733
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0044	0.0278	0.0616
Loa Loa (eye worm)	angiogenesis inhibito	0.0134	0.1345	0.1341
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0066	0.0736
Echinococcus multilocularis	tumor susceptibility gene 101 protein	0.0071	0.0595	0.0637
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0035	0.0348
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0147	0.0321
Trichomonas vaginalis	alpha-glucosidase, putative	0.0033	0.0138	0.1662
Loa Loa (eye worm)	hypothetical protein	0.013	0.13	0.1296
Schistosoma mansoni	hypothetical protein	0.0313	0.3487	0.8559
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0147	0.0154
Schistosoma mansoni	hypothetical protein	0.0076	0.0655	0.1599
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0034	0.0334
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0008	0.0102
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0173	0.0415
Echinococcus granulosus	GPCR family 2	0.0033	0.0147	0.0321
Echinococcus multilocularis	ceramide glucosyltransferase	0.0288	0.3185	0.3432
Leishmania major	hypothetical protein, conserved	0.0026	0.0056	0.0617
Echinococcus multilocularis	geminin	0.0362	0.4073	0.439
Onchocerca volvulus		0.0035	0.0173	0.0188
Echinococcus granulosus	bile acid beta glucosidase	0.0251	0.2748	0.6181
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0147	0.0143
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0173	0.2108
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0173	0.038
Entamoeba histolytica	tumor susceptibility gene 101 protein, putative	0.0048	0.0325	0.4039
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0056	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0607	0.0603
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0087	0.0792	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0173	0.5
Brugia malayi	beta-lactamase family protein	0.0035	0.0173	0.0169
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.01	0.0103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0035	0.0348
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.001	0.0121
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0035	0.0171	0.2073
Mycobacterium ulcerans	lipase LipD	0.0035	0.0173	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0093	0.1083
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0056	0.0617
Schistosoma mansoni	alpha-glucosidase	0.0339	0.3789	0.9303
Schistosoma mansoni	hypothetical protein	0.0033	0.0147	0.035
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0278	0.3445
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0034	0.0334
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.1004	0.1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0056	0.5234
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0056	0.0713
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0143	0.172
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0033	0.0138	0.1662
Echinococcus multilocularis	non lysosomal glucosylceramidase	0.0251	0.2748	0.296
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0044	0.0278	0.3445
Echinococcus multilocularis	a disintegrin and metalloproteinase with	0.0359	0.4032	0.4346
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0033	0.0143	0.172
Trichomonas vaginalis	rotamase, putative	0.0071	0.0603	0.7586
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0044	0.0278	0.0295
Onchocerca volvulus		0.0035	0.0173	0.0188
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0173	0.0415
Schistosoma mansoni	ceramide glucosyltransferase	0.0288	0.3185	0.7819
Loa Loa (eye worm)	hypothetical protein	0.017	0.1774	0.177
Trichomonas vaginalis	alpha-glucosidase, putative	0.0033	0.0138	0.1662
Echinococcus granulosus	tumor susceptibility gene 101 protein	0.0071	0.0595	0.1329
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0087	0.0792	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0173	0.2108
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0056	0.0617
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0173	0.0182
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0035	0.0343
Entamoeba histolytica	hypothetical protein	0.0076	0.0655	0.8255
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0173	0.5
Trypanosoma brucei	glucosidase, putative	0.0087	0.0792	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0169
Trichomonas vaginalis	esterase, putative	0.0035	0.0173	0.2108
Schistosoma mansoni	bile acid beta-glucosidase-related	0.0251	0.2748	0.6743
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0147	0.0321
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.017	0.2068
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0008	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0201	0.2461
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0173	0.2108
Schistosoma mansoni	ran	0.0022	0.0008	0.0009
Leishmania major	hypothetical protein, conserved	0.0023	0.002	0.0158
Trichomonas vaginalis	alpha-glucosidase, putative	0.0033	0.0138	0.1662
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0393	0.4443	0.4789
Echinococcus multilocularis	subfamily M12B unassigned peptidase	0.0116	0.1139	0.1224
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0278	0.0274
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0143	0.172
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.1004	0.1
Brugia malayi	hypothetical protein	0.0026	0.0056	0.0052
Echinococcus granulosus	subfamily M12B unassigned peptidase	0.0116	0.1139	0.2557
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0173	0.5
Trichomonas vaginalis	alpha-glucosidase, putative	0.0087	0.0792	1
Plasmodium vivax	importin-beta 2, putative	0.0029	0.01	0.5594
Trichomonas vaginalis	alpha-glucosidase, putative	0.0087	0.0792	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0076	0.0655	0.1465
Echinococcus granulosus	a disintegrin and metalloproteinase with	0.0359	0.4032	0.9074
Trichomonas vaginalis	alpha-glucosidase, putative	0.0033	0.0138	0.1662
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0066	0.0736
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0034	0.0334
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0076	0.0655	0.0702
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0035	0.0348
Brugia malayi	Ceramide glucosyltransferase	0.0288	0.3185	0.3182
Echinococcus granulosus	neutral alpha glucosidase AB	0.0087	0.0792	0.1774
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0034	0.0334
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.0288	0.3185	0.3541
Brugia malayi	angiogenesis inhibito	0.0264	0.2894	0.2891
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0033	0.0138	0.0149
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0173	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0271	0.2986	0.2983
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0173	0.2108
Onchocerca volvulus		0.0775	0.8986	1
Brugia malayi	beta-lactamase	0.0035	0.0173	0.0169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0035	0.0343
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0143	0.172
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0044	0.0278	0.3445
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0008	0.0003
Schistosoma mansoni	hypothetical protein	0.0362	0.4073	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0226	0.2451	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0775	0.8986	0.8986
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0169
Plasmodium falciparum	importin beta, putative	0.0029	0.01	1
Echinococcus granulosus	adam	0.0246	0.2689	0.6048
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0173	0.5
Brugia malayi	hypothetical protein	0.0076	0.0655	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1139	0.1135
Trypanosoma cruzi	hypothetical protein, conserved	0.0087	0.0792	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0087	0.0792	0.0787
Trichomonas vaginalis	hypothetical protein	0.0034	0.0162	0.1959
Echinococcus multilocularis	snurportin 1	0.0313	0.3487	0.3757
Loa Loa (eye worm)	hypothetical protein	0.0295	0.3262	0.3259
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0116	0.1139	0.2789
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0087	0.0792	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0278	0.3445
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0173	0.2108
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0173	0.0169
Brugia malayi	beta-lactamase family protein	0.0035	0.0173	0.0169
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.01	0.1179
Loa Loa (eye worm)	ceramide glucosyltransferase	0.0288	0.3185	0.3182
Leishmania major	glycosyl hydrolase-like protein	0.0033	0.0138	0.1662
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0278	0.3445
Schistosoma mansoni	rotamase	0.0071	0.0603	0.147
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0033	0.0138	0.1662
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.01	0.1269
Loa Loa (eye worm)	metalloprotease	0.0116	0.1139	0.1135
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.007	0.0582	0.733
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0035	0.0171	0.2154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0066	0.0736
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.001	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0063	0.0696
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0393	0.4443	0.444
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.007	0.0582	0.7357
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0056	0.5234
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0087	0.0792	1
Schistosoma mansoni	transcription factor LCR-F1	0.0076	0.0655	0.1599
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.001	0.0019
Brugia malayi	RNA, U transporter 1	0.0083	0.0746	0.0741
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0063	0.0696
Echinococcus granulosus	snurportin 1	0.0313	0.3487	0.7846
Trichomonas vaginalis	alpha-glucosidase, putative	0.0087	0.0792	1
Brugia malayi	hypothetical protein	0.0246	0.2689	0.2685
Schistosoma mansoni	hypothetical protein	0.0033	0.0147	0.035
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0087	0.0792	0.0787
Schistosoma mansoni	ADAMTS5 peptidase (M12 family)	0.0359	0.4032	0.9899
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0044	0.0278	0.3512
Echinococcus multilocularis	muscleblind protein	0.0295	0.3262	0.3515
Loa Loa (eye worm)	hypothetical protein	0.0295	0.3262	0.3259
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0595	0.059
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0044	0.0278	0.3445
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0143	0.172
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0044	0.0278	0.3512
Brugia malayi	Importin beta-1 subunit	0.0029	0.01	0.0096
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0104	0.1229
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0393	0.4443	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0169
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.007	0.0582	0.733
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.01	0.1269
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0173	0.5
Brugia malayi	metalloprotease	0.0116	0.1139	0.1135
Brugia malayi	hypothetical protein	0.0071	0.0595	0.059
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0116	0.1139	0.2789
Loa Loa (eye worm)	reprolysin	0.0116	0.1139	0.1135
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0603	0.7586
Echinococcus granulosus	geminin	0.0362	0.4073	0.9167
Trypanosoma cruzi	target of rapamycin kinase 3	0.0035	0.0171	0.2073
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0393	0.4443	0.444
Schistosoma mansoni	tsg101-related	0.0048	0.0325	0.0787
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0087	0.0792	0.0849
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0071	0.0603	0.0598
Schistosoma mansoni	alpha glucosidase	0.0087	0.0792	0.1935
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.017	0.2068
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0044	0.0278	0.3445
Schistosoma mansoni	hypothetical protein	0.0072	0.0607	0.1481
Loa Loa (eye worm)	hypothetical protein	0.0029	0.01	0.0096
Schistosoma mansoni	tsg101-related	0.0059	0.0453	0.1103
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.1004	0.1
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0033	0.0138	0.1662
Brugia malayi	Muscleblind-like protein	0.0295	0.3262	0.3259
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0035	0.0348
Echinococcus multilocularis	adam	0.0246	0.2689	0.2896
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0008	0.0003
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0173	1
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0087	0.0792	1
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0147	0.0143
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0008	0.0008
Onchocerca volvulus		0.0228	0.2464	0.2739
Schistosoma mansoni	ran	0.0022	0.0008	0.0009
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0147	0.0154
Echinococcus granulosus	lysosomal alpha glucosidase	0.0393	0.4443	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0173	0.5
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0022	0.001	0.0019
Entamoeba histolytica	hypothetical protein	0.0076	0.0655	0.8255
Schistosoma mansoni	ceramide glucosyltransferase	0.0288	0.3185	0.7819
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1004	0.1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0033	0.0138	0.1662
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0313	0.3487	0.3484
Schistosoma mansoni	hypothetical protein	0.0362	0.4073	1
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.007	0.0582	0.733
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0173	0.2189
Trypanosoma brucei	Vps23 core domain containing protein, putative	0.0023	0.002	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1139	0.1135
Echinococcus granulosus	expressed protein	0.0071	0.0603	0.1347
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0246	0.2689	0.6597
Trichomonas vaginalis	alpha-glucosidase, putative	0.0087	0.0792	1
Schistosoma mansoni	tsg101-related	0.0059	0.0453	0.1103
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0033	0.0138	0.0134
Onchocerca volvulus	Papilin homolog	0.0271	0.2986	0.332
Trichomonas vaginalis	alpha-glucosidase, putative	0.0087	0.0792	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0147	0.035
Schistosoma mansoni	importin beta-1	0.0029	0.01	0.0236
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0044	0.0278	0.0672
Entamoeba histolytica	hypothetical protein	0.0076	0.0655	0.8255
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0033	0.0138	0.1662
Echinococcus granulosus	importin subunit beta 1	0.0029	0.01	0.0216
Trichomonas vaginalis	alpha-glucosidase, putative	0.0033	0.0138	0.1662
Echinococcus granulosus	ceramide glucosyltransferase	0.0288	0.3185	0.7167
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0087	0.0792	1
Trypanosoma cruzi	Vps23 core domain containing protein, putative	0.0023	0.002	0.0158
Echinococcus granulosus	muscleblind protein	0.0295	0.3262	0.7341
Trypanosoma cruzi	hypothetical protein, conserved	0.0087	0.0792	1
Schistosoma mansoni	alpha-glucosidase	0.0339	0.3789	0.9303
Echinococcus multilocularis	bile acid beta glucosidase	0.0251	0.2748	0.296
Toxoplasma gondii	peptidylprolyl isomerase	0.007	0.0582	0.733
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0173	0.0169
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0607	0.0603
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.017	0.2068
Leishmania major	hypothetical protein, conserved	0.0035	0.0173	0.2108
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0173	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0138	0.0134
Schistosoma mansoni	hypothetical protein	0.0033	0.0147	0.035
Giardia lamblia	GTOR	0.0044	0.0278	0.2077
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0147	0.0154
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0034	0.0334
Toxoplasma gondii	PPIC-type PPIASE domain-containing protein	0.0022	0.001	0.0019
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.017	0.2068

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.04 uM	Inhibition of recombinant GBA2 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay	ChEMBL.	24900289
IC50 (binding)	= 1.2 uM	Inhibition of sucrase in mouse intestinal input by glucose release assay	ChEMBL.	24900289
IC50 (binding)	= 2 uM	Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay	ChEMBL.	24900289
IC50 (binding)	= 4 uM	Inhibition of maltase in mouse intestinal input by glucose release assay	ChEMBL.	24900289
IC50 (binding)	= 300 uM	Inhibition of lactase in mouse intestinal input by glucose release assay	ChEMBL.	24900289
IC50 (binding)	= 705 uM	Inhibition of recombinant GBA1 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay	ChEMBL.	24900289

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1651629

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1505022