TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 480.543 | Formula: C22H24N8O3S
H donors: 2 H acceptors: 6 LogP: 1.94 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1S(=O)(=O)C)N1CCN(CC1)c1nc(Nc2n[nH]c(c2)C)c2n(n1)ccc2
InChi: 1S/C22H24N8O3S/c1-15-14-19(26-25-15)23-20-17-7-5-9-30(17)27-22(24-20)29-12-10-28(11-13-29)21(31)16-6-3-4-8-18(16)34(2,32)33/h3-9,14H,10-13H2,1-2H3,(H2,23,24,25,26,27)
InChiKey: CHBAPBLNNGSPAO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Janus kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.2639	1
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0072	0.2639	0.2639
Echinococcus granulosus	calpain 5	0.0072	0.2639	0.2639
Schistosoma mansoni	unc-13 (munc13)	0.0072	0.2639	0.2639
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Schistosoma mansoni	synaptotagmin	0.0072	0.2639	0.2639
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Leishmania major	hypothetical protein, conserved	0.0072	0.2639	1
Onchocerca volvulus		0.0072	0.2639	1
Brugia malayi	Synaptotagmin I	0.0072	0.2639	0.9142
Brugia malayi	Protein kinase c protein 2	0.0072	0.2639	0.9142
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Echinococcus multilocularis	synaptotagmin 15	0.0072	0.2639	0.2639
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0072	0.2639	0.9142
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0178	0.0617
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Onchocerca volvulus		0.0072	0.2639	1
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0178	0.0617
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Echinococcus multilocularis	synaptotagmin	0.0072	0.2639	0.2639
Echinococcus granulosus	neural cell expressed developmentally	0.0072	0.2639	0.2639
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0072	0.2639	1
Leishmania major	c2 domain protein, putative	0.0072	0.2639	1
Trypanosoma cruzi	cAMP binding protein, putative	0.0072	0.2639	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0036	0.0124
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.1172	0.1172
Leishmania major	phospholipase c-like protein	0.0072	0.2639	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0072	0.2639	0.2639
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Echinococcus granulosus	intersectin 2	0.0072	0.2639	0.2639
Leishmania major	c2 domain protein, putative	0.0072	0.2639	1
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0072	0.2639	0.2639
Leishmania major	hypothetical protein, conserved	0.0072	0.2639	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Trichomonas vaginalis	copine, putative	0.0072	0.2639	1
Onchocerca volvulus		0.0072	0.2639	1
Entamoeba histolytica	hypothetical protein	0.0072	0.2639	1
Echinococcus multilocularis	myoferlin	0.0072	0.2639	0.2639
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Echinococcus granulosus	protein kinase c epsilon type	0.0072	0.2639	0.2639
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Schistosoma mansoni	synaptotagmin 12	0.0072	0.2639	0.2639
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.2129	0.2129
Toxoplasma gondii	hypothetical protein	0.0072	0.2639	0.0648
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.1172	0.1172
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0072	0.2639	0.2639
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0072	0.2639	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.2129	0.2129
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.2129	0.7926
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0072	0.2639	0.2639
Trichomonas vaginalis	synaptotagmin, putative	0.0072	0.2639	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.2639	1
Schistosoma mansoni	hypothetical protein	0.0072	0.2639	0.2639
Echinococcus multilocularis	extended synaptotagmin 2	0.0072	0.2639	0.2639
Echinococcus granulosus	synaptotagmin	0.0072	0.2639	0.2639
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0178	0.0617
Brugia malayi	protein kinase C II.	0.0072	0.2639	0.9142
Entamoeba histolytica	DENN domain protein	0.0072	0.2639	1
Echinococcus granulosus	otoferlin	0.0072	0.2639	0.2639
Leishmania major	hypothetical protein, conserved	0.0072	0.2639	1
Schistosoma mansoni	synaptotagmin-like protein	0.0072	0.2639	0.2639
Echinococcus multilocularis	synaptotagmin	0.0072	0.2639	0.2639
Toxoplasma gondii	hypothetical protein	0.0072	0.2639	0.0648
Echinococcus granulosus	synaptotagmin 15	0.0072	0.2639	0.2639
Entamoeba histolytica	C2 domain containing protein	0.0072	0.2639	1
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0072	0.2639	0.2639
Echinococcus granulosus	copine 9	0.0072	0.2639	0.2639
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.0072	0.2639	0.2639
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.2639	1
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0072	0.2639	1
Loa Loa (eye worm)	C2 domain-containing protein	0.0072	0.2639	0.9142
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0072	0.2639	0.2639
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0072	0.2639	0.2639
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Echinococcus multilocularis	UNCoordinated family member (unc 13)	0.0072	0.2639	0.2639
Echinococcus multilocularis	synaptotagmin	0.0072	0.2639	0.2639
Echinococcus multilocularis		0.0072	0.2639	0.2639
Trichomonas vaginalis	calcium-dependent lipid-binding protein, putative	0.0072	0.2639	1
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Trichomonas vaginalis	vab10 spectraplakin, putative	0.0072	0.2639	1
Loa Loa (eye worm)	copine family protein	0.0072	0.2639	0.9142
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1172	0.4061
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0072	0.2639	0.2639
Entamoeba histolytica	calcium-binding protein, putative	0.0072	0.2639	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Onchocerca volvulus		0.0072	0.2639	1
Schistosoma mansoni	synaptic ras gtpase activating protein syngap	0.0072	0.2639	0.2639
Brugia malayi	phospholipase C homolog	0.0072	0.2639	0.9142
Entamoeba histolytica	hypothetical protein, conserved	0.0072	0.2639	1
Trichomonas vaginalis	synaptotagmin, putative	0.0072	0.2639	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0072	0.2639	0.2639
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0072	0.2639	1
Schistosoma mansoni	synaptotagmin	0.0072	0.2639	0.2639
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0072	0.2639	1
Schistosoma mansoni	protein kinase C	0.0072	0.2639	0.2639
Trypanosoma brucei	C2 domain/Ankyrin repeats (3 copies), putative	0.0072	0.2639	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.2129	1
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0178	0.0617
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Trichomonas vaginalis	copine, putative	0.0072	0.2639	1
Echinococcus granulosus	synaptotagmin	0.0072	0.2639	0.2639
Onchocerca volvulus		0.0072	0.2639	1
Entamoeba histolytica	hypothetical protein	0.0072	0.2639	1
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Entamoeba histolytica	hypothetical protein	0.0072	0.2639	1
Trichomonas vaginalis	synaptotagmin, putative	0.0072	0.2639	1
Loa Loa (eye worm)	C2 domain-containing protein	0.0072	0.2639	0.9142
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.2639	0.2639
Trichomonas vaginalis	copine, putative	0.0072	0.2639	1
Trichomonas vaginalis	splicing factor 3A subunit, putative	0.0072	0.2639	1
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.1172	0.1172
Schistosoma mansoni	hypothetical protein	0.0072	0.2639	0.2639
Echinococcus multilocularis	protein piccolo	0.0072	0.2639	0.2639
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.2639	0.2639
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0072	0.2639	0.2639
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0072	0.2639	0.2639
Echinococcus multilocularis	copine 9	0.0072	0.2639	0.2639
Trichomonas vaginalis	copine, putative	0.0072	0.2639	1
Schistosoma mansoni	synaptotagmin	0.0072	0.2639	0.2639
Echinococcus granulosus	Immunoglobulin E set	0.0072	0.2639	0.2639
Brugia malayi	NEDD4.2	0.0072	0.2639	0.9142
Schistosoma mansoni	hypothetical protein	0.0072	0.2639	0.2639
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0072	0.2639	0.2639
Toxoplasma gondii	Sma protein	0.0072	0.2639	0.0648
Entamoeba histolytica	hypothetical protein	0.0072	0.2639	1
Echinococcus multilocularis	synaptotagmin	0.0072	0.2639	0.2639
Trypanosoma cruzi	C2 domain/Ankyrin repeats (3 copies), putative	0.0072	0.2639	1
Loa Loa (eye worm)	synaptotagmin-1	0.0072	0.2639	0.9142
Onchocerca volvulus	Multiple C2 domain and transmembrane region protein homolog	0.0072	0.2639	1
Trypanosoma cruzi	C2 domain containing protein, putative	0.0072	0.2639	1
Echinococcus multilocularis	copine 9	0.0072	0.2639	0.2639
Toxoplasma gondii	Elicitor-responsive protein, putative	0.0072	0.2639	0.0648
Leishmania major	hypothetical protein, conserved	0.0072	0.2639	1
Trypanosoma brucei	C2 domain containing protein, putative	0.0072	0.2639	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Echinococcus multilocularis	synaptotagmin	0.0072	0.2639	0.2639
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0072	0.2639	0.9142
Loa Loa (eye worm)	C2 domain-containing protein	0.0072	0.2639	0.9142
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0072	0.2639	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0072	0.2639	0.2639
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Trichomonas vaginalis	ion channel nompc, putative	0.0072	0.2639	1
Trichomonas vaginalis	annexin VII, putative	0.0072	0.2639	1
Entamoeba histolytica	C2 domain containing protein	0.0072	0.2639	1
Leishmania major	hypothetical protein, conserved	0.0072	0.2639	1
Entamoeba histolytica	C2 domain containing protein	0.0072	0.2639	1
Schistosoma mansoni	fer-1-related	0.0072	0.2639	0.2639
Echinococcus multilocularis	synaptotagmin 2	0.0072	0.2639	0.2639
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0178	0.0617
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.1172	0.1172
Entamoeba histolytica	C2 domain containing protein	0.0072	0.2639	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Brugia malayi	Synapse defective protein 1	0.0072	0.2639	0.9142
Trichomonas vaginalis	synaptotagmin, putative	0.0072	0.2639	1
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0072	0.2639	0.9142
Echinococcus granulosus	synaptotagmin	0.0072	0.2639	0.2639
Echinococcus granulosus	Protein kinase C brain isozyme	0.0072	0.2639	0.2639
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.1172	0.404
Leishmania major	copine i-like protein	0.0072	0.2639	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Brugia malayi	Copine VIII	0.0072	0.2639	0.9142
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0078	0.2887	1
Trichomonas vaginalis	copine, putative	0.0072	0.2639	1
Loa Loa (eye worm)	C2 domain-containing protein	0.0072	0.2639	0.9142
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Trypanosoma brucei	cAMP binding protein, putative	0.0072	0.2639	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Echinococcus multilocularis	calpain 5	0.0072	0.2639	0.2639
Echinococcus granulosus	extended synaptotagmin 2	0.0072	0.2639	0.2639
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.2129	1
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0072	0.2639	1
Entamoeba histolytica	hypothetical protein	0.0072	0.2639	1
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0072	0.2639	0.2639
Trichomonas vaginalis	Circumsporozoite protein precursor, putative	0.0072	0.2639	1
Echinococcus granulosus	synaptotagmin protein 4	0.0072	0.2639	0.2639
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0072	0.2639	0.2639
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.1172	0.1172
Trichomonas vaginalis	Proline-rich protein, putative	0.0072	0.2639	1
Trypanosoma brucei	synaptotagmin, putative	0.0072	0.2639	1
Trypanosoma brucei	predicted C2 domain protein	0.0072	0.2639	1
Echinococcus granulosus	myoferlin	0.0072	0.2639	0.2639
Entamoeba histolytica	hypothetical protein, conserved	0.0072	0.2639	1
Schistosoma mansoni	copine	0.0072	0.2639	0.2639
Entamoeba histolytica	C2 domain containing protein	0.0072	0.2639	1
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0072	0.2639	1
Trichomonas vaginalis	synaptotagmin, putative	0.0072	0.2639	1
Schistosoma mansoni	mctp-related	0.0072	0.2639	0.2639
Schistosoma mansoni	hypothetical protein	0.0072	0.2639	0.2639
Trypanosoma brucei	C2 domain containing protein, putative	0.0072	0.2639	1
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0072	0.2639	0.9142
Schistosoma mansoni	nedd-4-like E3 ubiquitin-protein ligase	0.0072	0.2639	0.2639
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.1172	0.404
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Schistosoma mansoni	otoferlin	0.0072	0.2639	0.2639
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Loa Loa (eye worm)	C2 domain-containing protein	0.0072	0.2639	0.9142
Entamoeba histolytica	protein kinase, putative	0.0072	0.2639	1
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Toxoplasma gondii	hypothetical protein	0.0072	0.2639	0.0648
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Brugia malayi	LD23056p	0.0072	0.2639	0.9142
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0072	0.2639	0.2639
Echinococcus granulosus	synaptotagmin 2	0.0072	0.2639	0.2639
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Echinococcus multilocularis	NEDD4 E3 ubiquitin protein ligase WWP1	0.0072	0.2639	0.2639
Brugia malayi	WW domain containing protein	0.0072	0.2639	0.9142
Onchocerca volvulus		0.0072	0.2639	1
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.1172	0.5
Entamoeba histolytica	protein kinase, putative	0.0072	0.2639	1
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.1172	0.1172
Echinococcus multilocularis	active breakpoint cluster region	0.0072	0.2639	0.2639
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Trypanosoma brucei	C2 domain containing protein, putative	0.0072	0.2639	1
Echinococcus granulosus	protein piccolo	0.0072	0.2639	0.2639
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Leishmania major	hypothetical protein, conserved	0.0072	0.2639	1
Trypanosoma brucei	C2 domain containing protein, putative	0.0072	0.2639	1
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.2639	0.2639
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.2639	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.2639	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Trypanosoma cruzi	synaptotagmin, putative	0.0072	0.2639	1
Trypanosoma brucei	predicted C2 domain protein	0.0072	0.2639	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0072	0.2639	0.2639
Schistosoma mansoni	unc-13 (munc13)	0.0072	0.2639	0.2639
Echinococcus granulosus	unc 13 munc13	0.0072	0.2639	0.2639
Loa Loa (eye worm)	C2 domain-containing protein	0.0072	0.2639	0.9142
Toxoplasma gondii	C2 domain-containing protein	0.0072	0.2639	0.0648
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.2129	0.2129
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Loa Loa (eye worm)	Nedd4-PD	0.0072	0.2639	0.9142
Schistosoma mansoni	hypothetical protein	0.0072	0.2639	0.2639
Schistosoma mansoni	synaptotagmin 12	0.0072	0.2639	0.2639
Echinococcus granulosus	NEDD4 E3 ubiquitin protein ligase WWP1	0.0072	0.2639	0.2639
Schistosoma mansoni	glut4 vesicle protein-related	0.0072	0.2639	0.2639
Brugia malayi	Copine family protein	0.0072	0.2639	0.9142
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.1172	0.4442
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.2639	1
Onchocerca volvulus		0.0072	0.2639	1
Echinococcus multilocularis	serine threonine protein kinase	0.0072	0.2639	0.2639
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.1172	0.1172
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.0072	0.2639	0.9142
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Schistosoma mansoni	E3 ubiquitin-protein ligase nedd-4	0.0072	0.2639	0.2639
Leishmania major	hypothetical protein, conserved	0.0072	0.2639	1
Brugia malayi	C2 domain containing protein	0.0072	0.2639	0.9142
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.2129	0.5
Brugia malayi	calpain 5	0.0072	0.2639	0.9142
Schistosoma mansoni	rabphilin-3a	0.0072	0.2639	0.2639
Entamoeba histolytica	C2 domain containing protein	0.0072	0.2639	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.2129	1
Trichomonas vaginalis	synaptotagmin, putative	0.0072	0.2639	1
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.1172	0.4061
Toxoplasma gondii	ferlin family protein	0.0072	0.2639	0.0648
Schistosoma mansoni	rho gtpase activating protein	0.0072	0.2639	0.2639
Leishmania major	hypothetical protein, conserved	0.0072	0.2639	1
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Schistosoma mansoni	synaptotagmin	0.0072	0.2639	0.2639
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Echinococcus multilocularis	synaptotagmin protein 4	0.0072	0.2639	0.2639
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.2639	1
Echinococcus granulosus	UNCoordinated family member unc 13	0.0072	0.2639	0.2639
Brugia malayi	Synaptotagmin protein 3	0.0072	0.2639	0.9142
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.2639	1
Entamoeba histolytica	hypothetical protein	0.0072	0.2639	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0072	0.2639	0.2639
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0072	0.2639	0.2639
Echinococcus granulosus	synaptotagmin	0.0072	0.2639	0.2639
Onchocerca volvulus		0.0072	0.2639	1
Echinococcus granulosus	protein kinase C gamma type	0.0072	0.2639	0.2639
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.2129	0.2129
Echinococcus multilocularis	unc 13 (munc13)	0.0072	0.2639	0.2639
Echinococcus granulosus	active breakpoint cluster region	0.0072	0.2639	0.2639
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.1172	0.1172
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0072	0.2639	0.2639
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Trypanosoma cruzi	Coiled-coil and C2 domain-containing protein	0.0072	0.2639	1
Trichomonas vaginalis	synaptotagmin, putative	0.0072	0.2639	1
Echinococcus granulosus	copine 9	0.0072	0.2639	0.2639
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.1172	0.404
Brugia malayi	Synapse defective protein 1	0.0072	0.2639	0.9142
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0072	0.2639	1
Trypanosoma brucei	Coiled-coil and C2 domain-containing protein	0.0072	0.2639	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.2639	1
Entamoeba histolytica	C2 domain containing protein	0.0072	0.2639	1
Toxoplasma gondii	phosphoinositide phospholipase PIPLC	0.0072	0.2639	0.0648
Schistosoma mansoni	synaptotagmin	0.0072	0.2639	0.2639
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0072	0.2639	0.9142
Entamoeba histolytica	C2 domain containing protein	0.0072	0.2639	1
Entamoeba histolytica	Rap/Ran GTPase activating protein, putative	0.0072	0.2639	1
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0072	0.2639	1
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0072	0.2639	0.2639
Echinococcus granulosus	synaptotagmin	0.0072	0.2639	0.2639
Trypanosoma brucei	predicted C2 domain protein	0.0072	0.2639	1
Entamoeba histolytica	C2 domain containing protein	0.0072	0.2639	1
Brugia malayi	Variant SH3 domain containing protein	0.0078	0.2887	1
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0072	0.2639	0.2639
Onchocerca volvulus	Putative cc2d1b protein	0.0072	0.2639	1
Echinococcus multilocularis	intersectin 2	0.0072	0.2639	0.2639
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.2639	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Echinococcus multilocularis	neural cell expressed, developmentally	0.0072	0.2639	0.2639
Schistosoma mansoni	synaptotagmin	0.0072	0.2639	0.2639
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0072	0.2639	0.2639
Trypanosoma cruzi	synaptotagmin, putative	0.0072	0.2639	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.1172	0.404
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2639	0.9142
Schistosoma mansoni	unc-13 (munc13)	0.0072	0.2639	0.2639
Entamoeba histolytica	C2 domain protein, putative	0.0072	0.2639	1
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0072	0.2639	0.2639

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.0011 uM	Inhibition of JAK2 after 60 mins	ChEMBL.	21282055

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1682380

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1505275