TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 442.487 | Formula: C19H27F5N2O2S
H donors: 1 H acceptors: 2 LogP: 4.15 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)C[C@H]([C@@H]1CC[C@H](CC1)N(S(=O)(=O)C)CCCC(F)(F)F)N)F
InChi: 1S/C19H27F5N2O2S/c1-29(27,28)26(10-2-9-19(22,23)24)16-6-3-13(4-7-16)18(25)12-14-11-15(20)5-8-17(14)21/h5,8,11,13,16,18H,2-4,6-7,9-10,12,25H2,1H3/t13-,16-,18-/m1/s1
InChiKey: WBUYZLAIVPLMAB-MZMPZRCHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dipeptidyl-peptidase 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0269	0.1441	1
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0063	0.0228	0.1523
Mycobacterium ulcerans	penicillin-binding membrane protein PbpB	0.1559	0.9024	1
Echinococcus multilocularis	transcription factor btf3	0.0028	0.0025	0.0173
Mycobacterium leprae	PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE)	0.0063	0.0228	0.0388
Trichomonas vaginalis	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0269	0.1441	0.2559
Mycobacterium ulcerans	penicillin-binding protein PbpA	0.098	0.562	0.6223
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0063	0.0228	0.1523
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0023	0.0086
Mycobacterium ulcerans	amidophosphoribosyltransferase	0.0063	0.0228	0.0242
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0057	0.0193	0.1275
Mycobacterium ulcerans	orotate phosphoribosyltransferase	0.0063	0.0228	0.0242
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0025	0.0026
Brugia malayi	hypothetical protein	0.036	0.1976	1
Brugia malayi	prolyl oligopeptidase family protein	0.0209	0.1088	0.5481
Chlamydia trachomatis	transglycolase/transpeptidase	0.1723	0.9988	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0061	0.0218	0.1513
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0035	0.0062	0.0357
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0026	0.0011	0.0074
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0063	0.0228	0.0388
Mycobacterium leprae	AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE)	0.0063	0.0228	0.0388
Treponema pallidum	hypothetical protein	0.0166	0.0833	0.0824
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0218	0.1055
Loa Loa (eye worm)	calcium channel	0.0057	0.0193	0.0928
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0061	0.0218	0.1513
Plasmodium vivax	orotate phosphoribosyltransferase, putative	0.0063	0.0228	0.1523
Mycobacterium tuberculosis	Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor	0.0206	0.107	0.1889
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0063	0.0228	0.1523
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0063	0.0228	0.1523
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0057	0.0193	0.134
Mycobacterium tuberculosis	Conserved protein	0.0063	0.0228	0.0388
Trypanosoma brucei	Adenine phosphoribosyltransferase, putative	0.0063	0.0228	0.1523
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0209	0.1088	0.5481
Mycobacterium tuberculosis	Conserved protein	0.0063	0.0228	0.0388
Schistosoma mansoni	jumonji domain containing protein	0.0061	0.0218	0.145
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0209	0.1088	0.7532
Echinococcus multilocularis	uridine 5' monophosphate synthase	0.0063	0.0228	0.1585
Echinococcus granulosus	zinc phosphodiesterase	0.0026	0.0011	0.0074
Loa Loa (eye worm)	ICD-1 protein	0.0028	0.0025	0.0073
Mycobacterium ulcerans	penicillin-binding lipoprotein	0.0558	0.3139	0.3471
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0061	0.0218	0.145
Leishmania major	xanthine phosphoribosyltransferase	0.0269	0.1441	1
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.007	0.0271	0.1823
Plasmodium falciparum	basic transcription factor 3b, putative	0.0028	0.0025	0.01
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.007	0.0271	0.1823
Leishmania major	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative	0.0063	0.0228	0.1523
Mycobacterium tuberculosis	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase	0.0296	0.1598	0.2831
Loa Loa (eye worm)	hypothetical protein	0.0331	0.1801	0.9111
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0269	0.1441	1
Plasmodium falciparum	orotate phosphoribosyltransferase	0.0063	0.0228	0.1523
Echinococcus multilocularis	ETHE1 protein	0.0026	0.0011	0.0074
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0063	0.0228	0.1523
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0209	0.1088	0.755
Entamoeba histolytica	hypothetical protein	0.0028	0.0025	0.7467
Giardia lamblia	Guanine phosphoribosyltransferase	0.0269	0.1441	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0023	0.0063
Onchocerca volvulus		0.036	0.1976	1
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.007	0.0271	0.1823
Mycobacterium tuberculosis	Probable pyrimidine operon regulatory protein PyrR	0.0063	0.0228	0.0388
Plasmodium vivax	basic transcription factor 3b, putative	0.0028	0.0025	0.01
Trypanosoma brucei	transcription factor BTF3, putative	0.0028	0.0025	0.01
Mycobacterium leprae	PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE	0.0977	0.56	0.9965
Onchocerca volvulus		0.0028	0.0023	0.0063
Schistosoma mansoni	voltage-gated cation channel	0.0057	0.0193	0.1275
Mycobacterium leprae	Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho	0.0206	0.107	0.1889
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0154	0.0765	0.384
Mycobacterium ulcerans	hypoxanthine-guanine phosphoribosyltransferase Hpt	0.0269	0.1441	0.1587
Trypanosoma cruzi	transcription factor btf3, putative	0.0028	0.0025	0.01
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0269	0.1441	1
Mycobacterium tuberculosis	Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase)	0.0063	0.0228	0.0388
Schistosoma mansoni	lamin	0.0028	0.0023	0.0086
Mycobacterium tuberculosis	Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen	0.0847	0.4835	0.8601
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0057	0.0193	0.134
Onchocerca volvulus	Adenine phosphoribosyltransferase homolog	0.0063	0.0228	0.1108
Treponema pallidum	penicillin-binding protein (pbp-2)	0.0977	0.56	0.5595
Loa Loa (eye worm)	hypothetical protein	0.036	0.1976	1
Treponema pallidum	hypothetical protein	0.0063	0.0228	0.0218
Echinococcus multilocularis	musashi	0.0028	0.0023	0.016
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0166	0.0833	0.1467
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0063	0.0228	0.1523
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0269	0.1441	1
Entamoeba histolytica	hypothetical protein	0.0029	0.003	1
Trypanosoma brucei	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0063	0.0228	0.1523
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0133	0.0638	0.1119
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0174	0.083
Echinococcus granulosus	lamin dm0	0.0028	0.0023	0.016
Mycobacterium leprae	POSSIBLE PENICILLIN-BINDING LIPOPROTEIN	0.0558	0.3139	0.5577
Loa Loa (eye worm)	hypothetical protein	0.036	0.1976	1
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0063	0.0228	0.1523
Echinococcus multilocularis	lysine specific demethylase 5A	0.0061	0.0218	0.1513
Entamoeba histolytica	hypothetical protein	0.0029	0.003	1
Trichomonas vaginalis	conserved hypothetical protein	0.0977	0.56	1
Echinococcus multilocularis	adenine phosphoribosyltransferase	0.0063	0.0228	0.1585
Mycobacterium ulcerans	hypothetical protein	0.0063	0.0228	0.0242
Trypanosoma cruzi	transcription factor btf3, putative	0.0028	0.0025	0.01
Echinococcus multilocularis	Protein lozenge	0.0045	0.0123	0.0857
Trichomonas vaginalis	Ribose-phosphate pyrophosphokinase, putative	0.0063	0.0228	0.039
Brugia malayi	hypothetical protein	0.0054	0.0174	0.083
Trichomonas vaginalis	ribose-phosphate pyrophosphokinase, putative	0.0063	0.0228	0.039
Toxoplasma gondii	orotate phosphoribosyltransferase	0.0063	0.0228	0.1523
Leishmania major	adenine phosphoribosyltransferase	0.0063	0.0228	0.1523
Brugia malayi	hypothetical protein	0.0127	0.0603	0.3016
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0057	0.0193	0.134
Loa Loa (eye worm)	adenine phosphoribosyltransferase	0.0063	0.0228	0.1108
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0035	0.0062	0.0357
Plasmodium falciparum	hypoxanthine-guanine phosphoribosyltransferase	0.0269	0.1441	1
Trypanosoma brucei	beta lactamase	0.0133	0.0638	0.4388
Mycobacterium tuberculosis	Probable penicillin-binding membrane protein PbpB	0.0415	0.2299	0.408
Entamoeba histolytica	hypothetical protein	0.0029	0.003	1
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.007	0.0271	0.1823
Loa Loa (eye worm)	runx1	0.0045	0.0123	0.0574
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0209	0.1088	0.755
Brugia malayi	hypothetical protein	0.0029	0.003	0.0097
Schistosoma mansoni	transcription factor LCR-F1	0.0029	0.003	0.0134
Plasmodium vivax	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0269	0.1441	1
Mycobacterium leprae	Probable penicillin-binding protein PbpA	0.098	0.562	1
Brugia malayi	orotate phosphoribosyltransferase family protein	0.0063	0.0228	0.1108
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0061	0.0218	0.1513
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0029	0.003	0.0207
Mycobacterium tuberculosis	Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase)	0.0063	0.0228	0.0388
Echinococcus granulosus	Dipeptidyl peptidase 9	0.007	0.0271	0.1883
Loa Loa (eye worm)	orotate phosphoribosyltransferase	0.0063	0.0228	0.1108
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0269	0.1441	1
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0269	0.1441	1
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0063	0.0228	0.1523
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0025	0.0026
Mycobacterium ulcerans	bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2	0.0847	0.4835	0.5352
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0026	0.0011	0.0074
Leishmania major	basic transcription factor 3a, putative	0.0028	0.0025	0.01
Echinococcus granulosus	uridine 5' monophosphate synthase	0.0063	0.0228	0.1585
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0133	0.0638	0.1119
Schistosoma mansoni	transcription factor btf3	0.0028	0.0025	0.01
Brugia malayi	intermediate filament protein	0.0028	0.0023	0.0063
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0269	0.1441	1
Brugia malayi	prolyl oligopeptidase family protein	0.007	0.0271	0.1326
Mycobacterium ulcerans	adenine phosphoribosyltransferase	0.0063	0.0228	0.0242
Trypanosoma brucei	Adenine phosphoribosyltransferase, putative	0.0063	0.0228	0.1523
Mycobacterium tuberculosis	Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase)	0.0063	0.0228	0.0388
Treponema pallidum	phosphoribosylpyrophosphate synthetase	0.0063	0.0228	0.0218
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0269	0.1441	1
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0269	0.1441	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.002	0.0047
Toxoplasma gondii	hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT	0.0269	0.1441	1
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.007	0.0271	0.1823
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0166	0.0833	0.1467
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0025	0.0026
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.007	0.0271	0.1823
Trichomonas vaginalis	set domain proteins, putative	0.0176	0.0891	0.1575
Echinococcus granulosus	ETHE1 protein	0.0026	0.0011	0.0074
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.007	0.0271	0.1883
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0063	0.0228	0.1523
Chlamydia trachomatis	transglycolase/transpeptidase	0.0816	0.4657	0.4657
Mycobacterium tuberculosis	Probable penicillin-binding protein PbpA	0.098	0.562	1
Brugia malayi	Pre-SET motif family protein	0.0154	0.0765	0.384
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0057	0.0193	0.134
Echinococcus multilocularis	hydroxyacylglutathione hydrolase	0.0026	0.0011	0.0074
Schistosoma mansoni	orotidine 5'-phosphate decarboxylase	0.0063	0.0228	0.1523
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0026	0.0011	0.0074
Mycobacterium ulcerans	lipoprotein LpqF	0.0133	0.0638	0.0696
Entamoeba histolytica	transcription factor BTF3, putative	0.0028	0.0025	0.7467
Leishmania major	hypoxanthine-guanine phosphoribosyltransferase	0.0269	0.1441	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0023	0.0063
Schistosoma mansoni	lamin	0.0028	0.0023	0.0086
Echinococcus multilocularis	voltage dependent calcium channel	0.0057	0.0193	0.134
Mycobacterium leprae	PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN	0.0847	0.4835	0.8601
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0029	0.003	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0193	0.0928
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0026	0.0011	0.0074
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0277	0.1484	0.1634
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0269	0.1441	1
Giardia lamblia	Adenine phosphoribosyltransferase	0.0063	0.0228	0.1523
Brugia malayi	jmjC domain containing protein	0.0061	0.0218	0.1055
Treponema pallidum	adenine phosphoribosyltransferase	0.0063	0.0228	0.0218
Onchocerca volvulus		0.0028	0.0023	0.0063
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0269	0.1441	1
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0057	0.0193	0.134
Treponema pallidum	penicillin-binding protein (pbp-1)	0.1723	0.9988	0.9988
Echinococcus multilocularis	lamin	0.0028	0.0023	0.016
Echinococcus granulosus	hydroxyacylglutathione hydrolase	0.0026	0.0011	0.0074
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0269	0.1441	1
Echinococcus granulosus	adenine phosphoribosyltransferase	0.0063	0.0228	0.1585
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0057	0.0193	0.1275
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0023	0.0063
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0061	0.0218	0.145
Echinococcus granulosus	lamin	0.0028	0.0023	0.016
Echinococcus multilocularis	zinc phosphodiesterase	0.0026	0.0011	0.0074
Onchocerca volvulus		0.0269	0.1441	0.7277
Echinococcus multilocularis	voltage dependent calcium channel	0.0057	0.0193	0.134
Toxoplasma gondii	NAC domain-containing protein	0.0028	0.0025	0.01
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0057	0.0193	0.134
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0023	0.0063
Echinococcus granulosus	transcription factor btf3	0.0028	0.0025	0.0173
Mycobacterium leprae	Probable penicillin-binding membrane protein PbpB	0.0415	0.2299	0.408
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.0277	0.1484	0.2626
Echinococcus multilocularis	lamin dm0	0.0028	0.0023	0.016
Onchocerca volvulus		0.0176	0.0891	0.4478
Mycobacterium ulcerans	serine/threonine-protein kinase B PknB	0.0166	0.0833	0.0913
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.007	0.0271	0.1823
Brugia malayi	beta-NAC-like protein	0.0028	0.0025	0.0073
Mycobacterium ulcerans	bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase	0.0063	0.0228	0.0242
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0063	0.0228	0.1523
Wolbachia endosymbiont of Brugia malayi	orotate phosphoribosyltransferase	0.0063	0.0228	0.0218
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0057	0.0193	0.134
Brugia malayi	jmjC domain containing protein	0.0061	0.0218	0.1055
Schistosoma mansoni	uracil phosphoribosyltransferase	0.0063	0.0228	0.1523
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0057	0.0193	0.0928
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0269	0.1441	1
Wolbachia endosymbiont of Brugia malayi	amidophosphoribosyltransferase	0.0063	0.0228	0.0218
Entamoeba histolytica	hypothetical protein	0.0029	0.003	1
Brugia malayi	Phosphoribosyl transferase domain containing protein	0.0269	0.1441	0.7277
Brugia malayi	Adenine phosphoribosyltransferase	0.0063	0.0228	0.1108
Echinococcus granulosus	intermediate filament protein	0.0028	0.0023	0.016
Schistosoma mansoni	lozenge	0.0045	0.0123	0.0789
Mycobacterium tuberculosis	Possible penicillin-binding lipoprotein	0.0558	0.3139	0.5577
Mycobacterium ulcerans	bifunctional penicillin-binding protein 1A/1B PonA1	0.0977	0.56	0.6201
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsI	0.1723	0.9988	1
Schistosoma mansoni	hypothetical protein	0.0029	0.003	0.0134
Loa Loa (eye worm)	prolyl oligopeptidase	0.0209	0.1088	0.5481
Echinococcus granulosus	voltage dependent calcium channel	0.0057	0.0193	0.134

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.4 uM	Inhibition of DPP4	ChEMBL.	21320777
IC50 (binding)	> 35 uM	Inhibition of FAP	ChEMBL.	21320777
IC50 (binding)	= 86 uM	Inhibition of QPP	ChEMBL.	21320777
IC50 (binding)	> 100 uM	Inhibition of DPP8	ChEMBL.	21320777
IC50 (binding)	> 100 uM	Inhibition of DPP9	ChEMBL.	21320777

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1683097

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1505562