Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0813 | 0.2147 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | cytochrome B | 0.0128 | 0.2617 | 0.2617 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0813 | 0.0813 |
Brugia malayi | Blistered cuticle protein 3 | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0813 | 0.2147 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.1261 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3784 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | Peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Toxoplasma gondii | cytochrome b | 0.0128 | 0.2617 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.1261 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Plasmodium vivax | cytochrome b | 0.0128 | 0.2617 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.1261 | 0.3332 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0903 | 0.2387 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0813 | 0.0813 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Plasmodium falciparum | cytochrome b | 0.0128 | 0.2617 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Echinococcus granulosus | peroxidasin | 0.0177 | 0.3712 | 0.3712 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.1261 | 0.3332 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.1261 | 0.3332 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0903 | 0.2387 |
Onchocerca volvulus | Peroxidasin homolog | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | Dual oxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0813 | 0.0813 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0128 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0555 | 0.1468 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0903 | 0.2387 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0555 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | Peroxidasin | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Brugia malayi | cytochrome b | 0.0128 | 0.2617 | 0.6914 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0152 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0152 | 0.0401 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Brugia malayi | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Brugia malayi | N-terminal motif family protein | 0.0181 | 0.3784 | 1 |
Loa Loa (eye worm) | cytochrome b | 0.0128 | 0.2617 | 0.6914 |
Echinococcus multilocularis | peroxidasin | 0.0177 | 0.3712 | 0.3712 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.1261 | 0.3332 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Schistosoma mansoni | peroxidasin | 0.0177 | 0.3712 | 1 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.1261 | 0.3332 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Toxoplasma gondii | apocytochrome b, putative | 0.0128 | 0.2617 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0152 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0152 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0903 | 0.2387 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0555 | 0.1468 |
Brugia malayi | RNA binding protein | 0.0066 | 0.1261 | 0.3332 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | cytochrome b | 0.0128 | 0.2617 | 0.7049 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0152 | 0.0152 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0813 | 0.0813 |
Schistosoma mansoni | cytochrome b | 0.0128 | 0.2617 | 0.7049 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0152 | 0.0152 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0181 | 0.3784 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | peroxidasin | 0.0177 | 0.3712 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 434.6 nM | Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
IC50 (functional) | = 495.1 nM | Antimalarial activity against chloroquine-,pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
IC50 (functional) | = 688.9 nM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 21316974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.